6794期

最新文章

• Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration AI翻译
  作者：Tsissios, Georgios; Leleu, Marion; Hu, Kelly; Demirtas, Alp Eren; Hu, Hanrong; Vinzens, Sabrina; Kawanishi, Toru; Skoufa, Evangelia; Valanju, Atharva; Valente, Alessandro; Noseda, Lorenzo; Ochi, Haruki; Herrera, Antonio; Sakar, Selman; Tanaka, Mikiko; Wickstrom, Sara A.; Zenk, Fides; Aztekin, Can
  作者单位：Swiss Federal Institutes of Technology Domain; Swiss School of Public Health (SSPH+); Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Max Planck Society; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Kobe University; Kobe University
  摘要：Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering environmental oxygen or stabilizing the oxygen-sensitive hypoxia-inducible factor 1A (HIF1A) induced rapid wound healing in mouse limbs. This response was accompanied by altered cellular mechanics, metabolism, and a histone landscape that primed rege...
• Luminal surface proteome of the brain vasculature uncovers blood-brain barrier regulators AI翻译
  作者：Zhu, Zijian; Jiang, Zuzhi; Wang, Yupu; Nguyen, Khanh; Zhang, Yuxiang; Lian, Cameron Genxuan; Mani, D. R.; Zheng, Jun; Ding, Lang; Gao, Shihong Max; Xia, Ruyue Alps; Kuszpit, Anne; Lindo, Sarah; Lopez, Crystall; Lindsey, Catherine; Groff, Brooke; Chen, Xinhong; Wu, Jiahui; Xia, Weiliang; Li, Wei; Liu, Xiaorong; Gradinaru, Viviana; Carr, Steven A.; Udeshi, Namrata D.; Li, Jiefu
  作者单位：Howard Hughes Medical Institute; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Peking University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; California Institute of Technology; Howard Hughes Medical Institute; California Institute of Technology; University of Virginia; University of Virginia (UVA) Health System; University of Virginia; University of Virginia; University of Virginia; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI); University of California System; University of California San Francisco; Shanghai Jiao Tong University
  摘要：At the blood-tissue interface, vasculature luminal surface is critical for molecular transport, signaling transduction, and cell extravasation. Here, we present a method for proteomic profiling of the vasculature luminal surface in vivo, broadly applicable to any vertebrate. Quantitative mass spectrometry revealed the luminal surface proteome of the mouse brain vasculature and its temporal evolution from development to aging. In vivo genetic perturbation found that the arginine transporter SLC...
• Civil war among wild chimpanzees AI翻译
  作者：Brooks, James
  作者单位：Leibniz Association; Deutsches Primatenzentrum (DPZ)
• Magma plumbing beneath Yellowstone AI翻译
  作者：Farrell, Jamie
  作者单位：Utah System of Higher Education; University of Utah
• A bad crowd AI翻译
  作者：Leslie, Mitch
• Shape anisotropy governs organization of active rods: Swarming, turbulence, flocking, and jamming AI翻译
  作者：Shelke, Yogesh; Nair S, Anpuj; Vutukuri, Hanumantha Rao
  作者单位：University of Twente
  摘要：Shape anisotropy of individual building blocks plays a crucial role in creating exotic structures and controlling phase behavior in equilibrium systems. We present a combined experimental and simulation study in which we used light-driven self-propelled rods to investigate when and how shape-induced alignment and steric and hydrodynamic interactions govern self-organization. Varying rod aspect ratio and area fraction causes the system to evolve from active Brownian motion to swarming, active t...
• Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity AI翻译
  作者：Chung, Jooho; Vallurupalli, Mounica; Noel, Sarah; Schor, Gail; Mrowka, Sofia; Scapozza, Ilario; Demere, Zelalem; Kammula, Sachin V.; Hu, Margaret; Kim, Sarah Y.; Liu, YuhJong; Nobrega, Celeste; Perera, Jonathan J.; Wrona, Ewa; Cheruiyot, Collins K.; Lin, Yunkang; Wu, David W.; Saberi, Maria; Cruickshank, Aidan; Woods, Elliot C.; Chuong, Cun Lan; Birocchi, Filippo; Kammula, Ashwin V.; Avila, Omar I.; Knudsen, Nelson; Kocak, Mustafa; Doench, John G.; Procter, Dean; Thornton, Lindsey; Brunner, Andrew M.; Winer, Eric; DeAngelo, Daniel J.; Garcia, Jacqueline S.; Stone, Richard M.; Jenkins, Russell W.; Maus, Marcela V.; Graubert, Timothy A.; Yates, Kathleen B.; Golub, Todd R.; Manguso, Robert T.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Medical University Lodz; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
  摘要：Macrophages exert antitumorigenic activity through phagocytosis, but phagocytosis-enhancing therapeutics have not improved acute myeloid leukemia (AML) outcomes. To identify phagocytosis regulators, we performed CRISPR knockout screens in human AML cells cocultured with human macrophages. We found that the don't eat me signal CD47 inhibited mouse but not human macrophage phagocytosis. However, O-linked glycosylation and sialylation were strong negative regulators of phagocytosis. In AML, the c...
• Pesticides may wreak havoc on the gut microbiome Disruption of complex intestinal ecosystem could contribute to diabetes and other health issues, scientists say AI翻译
  作者：Jain, Sanket
• We survived COVID-19-Are we ready for Nipah? AI翻译
  作者：Khan, Sikandar; Zhang, Ruiyong; Khan, Alamgir; Shah, Abdullah; Tan, Qinghai
  作者单位：Chinese Academy of Sciences; Institute of Oceanology, CAS; Huazhong University of Science & Technology