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作者：Righi, Laurie; Stutzmann, Sandrine; Bader, Loriane; Lemopoulos, Alexandre; Blokesch, Melanie
作者单位：Swiss Federal Institutes of Technology Domain; Swiss School of Public Health (SSPH+); Ecole Polytechnique Federale de Lausanne
摘要：Bacteria often survive viral attack and environmental stress by sharing genes that enhance their defenses. The cholera pathogen Vibrio cholerae carries a sedentary chromosomal integron (SCI), a genetic element containing hundreds of mostly promoterless gene cassettes, about 10% of which encode antiviral systems. Cassettes are thought to reshuffle under stress to the favorable first array position, yet the SCI in pandemic V. cholerae has remained static for more than 60 years. In this study, we...
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作者：Hall, Peter
作者单位：New York University
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作者：Cho, Adrian
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作者：Greenbaum, Dov; Gerstein, Mark
作者单位：Reichman University; Yale University; Yale University; Yale University
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作者：Kelch, Riley M.; Hammerling, Lea; Zysman-Colman, Eli; Yoon, Tehshik P.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of St Andrews
摘要：Modern organic synthesis relies upon the availability of chiral catalysts to control the stereochemistry of bond-forming reactions. Several families of chiral catalysts have become recognized as privileged structures because of their notable generality for diverse transformations with different reaction mechanisms. However, examples of highly enantioselective photocatalyst structures remain scarce. We have designed a family of enantioselective photocatalysts by modifying the structures of priv...
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作者：Jirovec, D.; Reale, S.; Cova Farina, P.; Ventura-Meinersen, C.; Nguyen, M. P.; Zhang, X.; Oosterhout, S. D.; Scapucci, G.; Veldhorst, M.; Rimbach-Russ, M.; Bosco, S.; Vandersypen, L. M. K.
作者单位：Delft University of Technology; Netherlands Organization Applied Science Research
摘要：Quantum simulators enable studies of many-body phenomena, which are intractable with classical hardware. The manipulation of electronic spin states in devices based on semiconductor quantum dots promises precise electrical control and scalability advantages, but accessing many-body phenomena has so far been restricted by challenges in nanofabrication and simultaneous control of multiple interactions. In this study, we performed spectroscopy of up to eight interacting spins using a 2-& times;-4...
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作者：Wang, Fayuan
作者单位：Qingdao University of Science & Technology
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作者：Soundararajan, Soundarya
作者单位：Indian Council of Medical Research (ICMR)
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作者：Kavokin, Alexey; Kavokina, Stella
作者单位：Westlake University
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作者：Mui, Byron W. H.; Wong, Joseph J. Y.; Dumas, Camille E.; Wang, Jia Hua; Bray, Toni; Hirose, Kentaro; Connolly, Lauren; Winkel, Alexander; Timmler, Sebastian; Bright, Nicholas A.; Sliauteryte, Evelina; Karadottir, Ragnhildur Thora; Robey, Pamela G.; Franze, Kristian; Chalut, Kevin J.; Storer, Mekayla A.
作者单位：University of Cambridge; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); National Institutes of Health (NIH) - USA; Stanford Medicine; Stanford University; University of Cambridge; University of Cambridge; University of Iceland; University of Erlangen Nuremberg; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Babraham Institute
摘要：Tissue regeneration is rare in mammals, but the digit tip can regrow after amputation, whereas injuries beyond the nail do not. How the microenvironment drives divergent outcomes remains unclear. In this study, we found that the extracellular matrix (ECM) and tissue mechanics govern the amputation response in mouse digits. Nonregenerative regions were stiffer and contained dense, organized collagen, whereas regenerative regions were soft and enriched in hyaluronic acid (HA). Depleting HA inhib...
