6812期

最新文章

• The scales of strain on sharks AI翻译
  作者：Roopnarine, Peter D.
  作者单位：California Academy of Sciences
• Shark governance requires species identity AI翻译
  作者：Bornatowski, Hugo; Barreto, Rodrigo
• Hidden costs of China's straw-burning ban AI翻译
  作者：Feng, Xinhui; Zhang, Qirui; Li, Yan; Wang, Yimin
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University
• Artificial hibernation reveals synaptic engram architecture associated with memory retention AI翻译
  作者：Lin, Y. J.; Takahashi-Nakazato, A.; Tsutsumi, K.; Takahashi, T.; Mercier, D.; Ashitomi, H.; Chiang, M. C.; Haberl, M.; Uytiepo, M.; Maximov, A.; Makino, Y.; Nemoto, T.; Enoki, R.; Hirano, A.; Soga, K.; Looprasertkul, S.; Ohno, N.; Kubota, Y.; Sakurai, T.; Tanaka, K. Z.
  作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Institute for Physiological Sciences (NIPS); National Institutes of Natural Sciences (NINS) - Japan; The Exploratory Research Center on Life & Living Systems (ExCELLS); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Scripps Research Institute; Scripps Research Institute; Graduate University for Advanced Studies - Japan; University of Tsukuba; University of Tsukuba; University of Tsukuba; Jichi Medical University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Chulalongkorn University
  摘要：Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal representations after memory formation suggest alternative possibilities. To elucidate the structural trace underlying memory retention, we used a mouse model of artificial hibernation. During hibernation, hippocampal neurons exhibited a substantial reduction in their activity and an extensive elimination...
• Researchers struggle to improve nonopioid pain drugs AI翻译
  作者：Smith, Jennie Erin
• A cross-organ single-cell analysis of hypertension AI翻译
  作者：Qiu, Qiongzi; Liu, Yong; Xue, Hong; Pandey, Rajan; Liu, Jing; He, Lishu; Liu, Pengyuan; Therani, Bhavika; Kumar, Vinod; Huang, Jing; Sadri, Shima; Guenther, Maya; Usa, Kristie; Grzybowski, Michael; Vanden Avond, Mark A.; Greene, Andrew S.; Cowley, Allen W.; Rao, Sridhar; Geurts, Aron M.; Liang, Mingyu
  作者单位：University of Arizona; University of Arizona Health Sciences; University of Arizona Health Sciences; University of Arizona; Medical College of Wisconsin; Jackson Laboratory; Medical College of Wisconsin; Medical College of Wisconsin
  摘要：Hypertension is a leading cause of disease burden and mortality. Here, we present a single-cell analysis of hypertension and end-organ damage across six organs and tissues in angiotensin II-treated mice, Dahl salt-sensitive rats, and spontaneously hypertensive rats. We identified gene programs associated with blood pressure and renal injury, including a conserved vascular smooth muscle cell program and cross-segment renal tubular programs, along with tissue-specialized endothelial adaptations ...
• Fossil denticles reveal how ocean productivity shapes shark baselines and recovery potential AI翻译
  作者：Dillon, Erin M.; McCauley, Douglas J.; Gonzalez, Migdonio; Connolly, Sean R.; de Gracia, Brigida; Cybulski, Jonathan D.; Norris, Richard D.; Gomez, Maria Mercedes; Garcia-Perez, Irene; Leonard, Nicole D.; Zhao, Jian-xin; Garcia-Mendez, Kimberly; O'Dea, Aaron
  作者单位：Smithsonian Institution; Smithsonian Tropical Research Institute; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; James Cook University; University of Rhode Island; University of Hong Kong; University of California System; University of California San Diego; Scripps Institution of Oceanography; Escuela Superior Politecnica del Litoral; University of Calgary
  摘要：Shark populations on coral reefs have declined globally, but few baselines exist to quantify natural variability before human impact. Using fossil dermal denticles preserved in reef sediments, we reconstructed shark communities across the Isthmus of Panama before substantial exploitation [similar to 7 to 3 thousand years ago (ka)] and recently (past century). We found differences in shark baselines and responses to fishing between the oceans on either side of the Isthmus. Reefs in the Pacific ...
• 'Mismatched' Ebola vaccine may soon be rolled out widely AI翻译
  作者：Kupferschmidt, Kai
• Planned satellite constellations risk runaway debris AI翻译
  作者：Richter, Hannah
• TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges AI翻译
  作者：Fujisawa, Ryo; Labib, Karim P. M.
  作者单位：University of Dundee
  摘要：Mammalian cells frequently enter mitosis before DNA replication has finished, necessitating the rapid processing of unreplicated loci to facilitate chromosome segregation. The TRAIP ubiquitin ligase induces replisome disassembly during mitosis, triggering the cleavage of DNA replication forks. Until now, the mechanisms that regulate TRAIP and process cleaved DNA replication forks were unclear. In this study, we show that the transcription termination factor 2 (TTF2) adenosine triphosphatase is...