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作者：Curry, Andrew
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作者：Tsai, Hanshen; Matsuda, Takuya; Kondou, Kouta; Shimizu, Kotaro; Nomoto, Takuya; Higo, Tomoya; Matsuo, Takumi; Tsushima, Yutaro; Asakura, Mihiro; Peng, Hanyi; Nishio-Hamane, Daisuke; Yamada, Shogo; Tang, Rui; Iizuka, Tetsuya; Miwa, Shinji; Arita, Ryotaro; Takenaka, Mitsuru; Nakatsuji, Satoru
作者单位：University of Tokyo; University of Osaka; Tokyo Metropolitan University; University of Tokyo; University of Tokyo; University of Tokyo; Johns Hopkins University; Johns Hopkins University
摘要：Developing an ultrafast and energy-efficient nonvolatile switching device may pose a strong impact on emerging computing architectures. However, processing speed has plateaued in the nanosecond regime, as further acceleration demands excessively large write power. We demonstrate ultralow power in picosecond switching using heterostructures of the antiferromagnet Mn3Sn and heavy metal tantalum, which exhibit spin-orbit torque switching by electrical pulses as short as 40 picoseconds. Power cons...
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作者：Pardo-Manuel de Villena, Fernando; Amos-Landgraf, James M.; Bell, Timothy A.; Blanchard, Matthew W.; Brennan, Jennifer; Carlson, Charisse; Ciavatta, Dominic J.; Cotney, Paul A.; Ferris, Martin T.; Hock, Pablo; Korf, Ian; Lloyd, K. C. Kent; Lutz, Cathleen; Lynch, Rachel M.; Magnuson, Terry; Murray, Stephen A.; Patel, Samit; Reinholdt, Laura G.; Sigmon, John Sebastian; Willis, Brandon; Xenakis, James G.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Missouri System; University of Missouri Columbia; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of California System; University of California Davis; Jackson Laboratory; University of North Carolina; University of North Carolina Chapel Hill
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作者：Harimoto, Tetsuhiro; Herrero Quevedo, Fernando; Zillig, Janis; Schreiber, Sanjay; Wu, Yi; Ahn, Christine Heera; To, Tania; Thakur, Rohan; Tatara, Alexander M.; Kang, Shawn; Chen, Zheqi; Lafuente-Gomez, Nuria; Hanan, Blake; Pauer, Alexander; Lightbown, Shanda; Weitz, David A.; Mooney, David J.
作者单位：Harvard University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Texas System; University of Texas Southwestern Medical Center; Harvard University
摘要：Microbes are increasingly used as living therapeutics, yet their uncontrolled dissemination in the body has remained a clinical roadblock. Physical containment remains largely unattainable owing to eventual bacteria escape. In this work, we present an implantable material that encapsulates and confines bacteria, wherein synthetically engineered microbes produce therapeutic payloads from within. We developed a hydrogel scaffold with dual mechanical features: high stiffness to regulate bacterial...
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作者：Smith, Jennie Erin
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作者：Conde, Joao
作者单位：Universidade Nova de Lisboa
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作者：Rodriguez, Grayson E.; Zhao, Yang; Nishiga, Yoko; Peprah, Frank; Shen, Jiao; Abhiraman, Gita C.; Ogishi, Masato; Zhang, Chenyu; Saco, Justin; Waghray, Deepa; Serasanambati, Mamatha; Torres, Leonel; Simone, Brandon W.; Su, Leon; Wilson, Steven C.; Yang, Aerin; Sun, Qinli; Picton, Lora; Saxton, Robert A.; Bhandarkar, Vidit; Lee, Madeline J.; Andrews, Elizabeth; Jiang, Hua; Obenaus, Matthias; Yen, Michelle; Atajanova, Tavus; Blish, Catherine A.; Spranger, Stefani; Wherry, E. John; Kirane, Amanda; Ribas, Antoni; Raulet, David H.; Kalbasi, Anusha; Dougan, Stephanie K.; Dougan, Michael; Sage, Julien; Garcia, K. Christopher
作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford Medicine; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; University of California System; University of California Berkeley; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Stanford Medicine; Stanford University; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Massachusetts Institute of Technology (MIT); Stanford Medicine; Stanford University; Chan Zuckerberg Initiative (CZI); University of Pennsylvania; Pennsylvania Medicine; University of California System; UCLA Jonsson Comprehensive Cancer Center; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford Cancer Institute; Harvard University; Harvard Medical School; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Howard Hughes Medical Institute
摘要：Cytokines dimerize two receptor chains to activate Janus kinases and signal transducer and activator of transcription (STAT) transcription factors that regulate immune cells, but they have therapeutic liabilities. We engineered Trikines to compel cis formation of three-chain cytokine receptor complexes at the cell surface that induce bespoke STAT transcriptional signaling programs. Trikines coactivated phosphorylation of STAT5 (pSTAT5) and pSTAT3 signatures distinct from natural cytokines by a...
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作者：Alberti, Marina; Grimm, Nancy B.; Palkovacs, Eric P.; Urban, Mark C.; Verrelli, Brian C.; Anderson, Pippin; Carlen, Elizabeth J.; Cocciardi, Jennifer M.; Cook, Elizabeth M.; Fortin, Marie-Josee; Gotanda, Kiyoko M.; Hobbie, Sarah E.; Johnson, Marc T. J.; Li, Daijiang; Malesis-Dahm, Anna N.; Miles, Lindsay S.; Munshi-South, Jason; Roman-Palacios, Cristian; Phifer-Rixey, Megan; Salazar-Valenzuela, David; Savage, Amy M.; Snyder, Rebecca; Winchell, Kristin M.; Zhou, Yuyu
作者单位：University of Washington; University of Washington Seattle; Arizona State University; Arizona State University-Tempe; University of California System; University of California Santa Cruz; University of Connecticut; Virginia Commonwealth University; University of Cape Town; Washington University (WUSTL); University of Mississippi; Columbia University; Cary Institute of Ecosystem Studies; University of Toronto; Brock University; University of Minnesota System; University of Minnesota Twin Cities; University of Toronto; University Toronto Mississauga; University of Wisconsin System; University of Wisconsin Madison; Virginia Polytechnic Institute & State University; Drexel University; University of Arizona; Drexel University; Pontificia Universidad Catolica del Ecuador; New York University; University of Hong Kong; University of Hong Kong
摘要：Despite growing investments in nature-based solutions for urban resilience, their design often overlooks a fundamental biological process: evolution. Populations of organisms that sustain nature-based solutions are dynamic and can evolve over time. Rapid evolutionary changes, driven by urban environmental stressors, such as pollution, climate extremes, and habitat fragmentation, can reshape species' traits, alter interactions, and shift ecosystem functions. We synthesize evidence of evolutiona...
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作者：Basilio, Humberto
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作者：Scarborough, Emily A.; Randell, Rani M.; Uchida, Keita; Stone, Kathlyene R.; Margulies, Kenneth B.; Prosser, Benjamin L.
作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; University of Pennsylvania; Oakland University
摘要：The adult heart grows by the addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. We found that microtubule dynamics could act as a toggle to direct cardiomyocyte growth. Increasing microtubule stability drove cellular widening, concomitant with redirecting messenger RNa (mRNa) export and translation along the width of the cell and reinforcement of the intercalated disc. Conversely, decreasing microt...
