作者：Cheng, Myra; Lee, Cinoo; Khadpe, Pranav; Jurafsky, Dan
作者单位：Stanford University; Stanford University; Carnegie Mellon University
作者：Mattiuz, Raphael; Boumelha, Jesse; Aerakis, Emmanouil; Le Berichel, Jessica; Hamon, Pauline; Halasz, Laszlo; Vaidya, Abishek; Soong, Brian Y.; Radkevich, Emir; Kim, Hye Mi; Park, Matthew D.; Donne, Romain; Troncoso, Leanna; Kaplan, Rachel A.; Hennequin, Clotilde; Hernandez-Verdin, Isaias; Lopez, Lucia; Rentzeperis, Frederika; D'Souza, Darwin; Kaiza, Medard Ernest; MacFawn, Ian P.; Belabed, Meriem; Mestrallet, Guillaume; Humblin, Etienne; Merand, Raphael; Hegde, Samarth; Lone, Jean-Christophe; Ioannou, Giorgio; Ozbey, Sinem; Figueiredo, Igor; Tepper, Alexander; Merarda, Hajer; Serhan, Nadine; Schaefer, Maximilian M.; An, Jinping; Ohara, Ray A.; Nemeth, Erika; Goldstein, Simon; Reid, Amanda M.; Noureddine, Moataz; Tabachnikova, Alexandra; Piperno, Giulia Maria; Tsoumakidou, Maria; Ahmed, Jalal; Polydorides, Alexandros D.; Bhardwaj, Nina; Lujambio, Amaia; Chen, Zhihong; Gonzalez Kozlova, Edgar; Kim-Schulze, Seunghee; Brody, Joshua D.; Schotsaert, Michael; Moussion, Christine; Gnjatic, Sacha; Roudko, Vladimir; Ginhoux, Florent; Murphy, Kenneth M.; Sautes-Fridman, Catherine; Fridman, Wolf Herman; Brown, Brian D.; Marron, Thomas U.; Benvenuti, Federica; Cyster, Jason G.; Salmon, Helene; Bruno, Tullia C.; Joshi, Nikhil S.; Kamphorst, Alice O.; Merad, Miriam
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Universite Paris Cite; Sorbonne Universite; International Center for Genetic Engineering & Biotechnology (ICGEB); Icahn School of Medicine at Mount Sinai; Universidade de Lisboa; Universidade de Lisboa; Icahn School of Medicine at Mount Sinai; Howard Hughes Medical Institute; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Washington University (WUSTL); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Roche Holding; Roche Holding USA; Genentech; Universite Paris Saclay; UNICANCER; Institut National de la Sante et de la Recherche Medicale (Inserm); Gustave Roussy; Icahn School of Medicine at Mount Sinai; UNICANCER; Universite PSL; Institut Curie; Yale University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：Tertiary lymphoid structures (TLSs) are associated with immunotherapy response, yet the mechanisms controlling their formation and maintenance remain unclear. Using spatial transcriptomics and multiplex imaging across human tumors, we found that CCR7+ mature dendritic cells (DCs) accumulate in TLSs. In a mouse non-small cell lung cancer model that forms mature TLSs, we show that early TLS development requires interferon-gamma (IFN-gamma)-driven type 1 conventional dendritic cell (cDC1) maturat...
