6809期

最新文章

• The tangled world of snake taxonomy AI翻译
  作者：Kemp, Christopher
  作者单位：Michigan State University
• Alzheimer's trial results lend momentum to drugs targeting tau AI翻译
  作者：Smith, Jennie Erin
• University science in the US needs a coherent plan AI翻译
  作者：Thorp, H. Holden
• Contagious fish cancer overruns New England lake AI翻译
  作者：Appenzeller, Tim
• A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation AI翻译
  作者：Cheng, Yubao; Wang, Jianshu; Zhang, Yuan; Yadavalli, Anurupa Devi; Liu, Miao; Jin, Shengyan; Buddle, Grace; Haberman, Ann; Schatz, David G.; Wang, Siyuan
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale New Haven Hospital.
  摘要：B cell maturation within the germinal center tissue microenvironment involves immunoglobulin gene diversification by somatic hypermutation (SHM). How three-dimensional (3D) genome architecture influences SHM is not fully understood. We leveraged sequencing-based and image-based 3D genomics and transcriptomics to map single-cell 3D genome organization and gene expression across cell types and states in human tonsils and in B cell lymphoma cell lines. These analyses revealed trajectories of comp...
• Detention of US seismologist by China alarms researchers AI翻译
  作者：Stone, Richard
• Climate scientists sharpen tools for linking global warming to extreme weather AI翻译
  作者：Vaz, Julia
• Human body single-cell atlas of three-dimensional genome organization and DNA methylation AI翻译
  作者：Zhou, Jingtian; Wu, Yue; Liu, Hanqing; Tian, Wei; Castanon, Rosa G.; Bartlett, Anna; Zhang, Zuolong; Yao, Guocong; Shi, Dengxiaoyu; Clock, Ben; Marcotte, Samantha; Nery, Joseph R.; Liem, Michelle; Claffey, Naomi; Boggeman, Lara; Barragan, Cesar; Arrojo e Drigo, Rafael; Weimer, Annika K.; Shi, Minyi; Cooper-Knock, Johnathan; Zhang, Sai; Snyder, Michael P.; Preissl, Sebastian; Ren, Bing; O'Connor, Carolyn; Chen, Shengbo; Luo, Chongyuan; Dixon, Jesse R.; Ecker, Joseph R.
  作者单位：Salk Institute; University of California System; University of California San Diego; University of California System; University of California San Diego; Harvard University; Henan University; Henan University; Salk Institute; Salk Institute; Vanderbilt University; Vanderbilt University; Vanderbilt University; Stanford University; Stanford Medicine; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Sheffield; Yale University; State University System of Florida; University of Florida; University of California System; University of California San Diego; University of Freiburg; University of Graz; University of Graz; University of California System; University of California San Diego; Nanchang University; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Salk Institute; Howard Hughes Medical Institute
  摘要：Higher-order chromatin structure and DNA methylation are critical for gene regulation, but how these vary across the human body remains unclear. We performed multiomic profiling of three-dimensional (3D) genome structure and DNA methylation for 86,689 single nuclei across 16 tissues, identifying 35 major and 206 cell subtypes. We revealed extensive changes in CG and non-CG methylation across cell types and characterized 3D chromatin structure at an unprecedented cellular resolution. Extensive ...
• No strain, no gain AI翻译
  作者：Kraft, Fabian B.; Gehringer, Matthias
  作者单位：Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen
• Late-stage functionalization with strain-release warheads enables tunable covalent inhibition AI翻译
  作者：Shultz, Zachary P.; Lee-Sam, Ansar; Chang, Yun-Pu; Sun, Luxin; Grassie, Dylan; Gabellini, Alessio; Pedretty, Kyle; Scattolin, Thomas; Izumi, Victoria; Fang, Bin; Sansil, Samer; Kakumanu, Ramu; Wojtas, Lukasz; Koomen, John; Schonbrunn, Ernst; Monastyrskyi, Andrii; Duckett, Derek; Lopchuk, Justin M.
  作者单位：H Lee Moffitt Cancer Center & Research Institute; State University System of Florida; University of South Florida; H Lee Moffitt Cancer Center & Research Institute; H Lee Moffitt Cancer Center & Research Institute; H Lee Moffitt Cancer Center & Research Institute; State University System of Florida; University of South Florida
  摘要：Covalent inhibition continues to gain momentum as a strategy for selective protein modulation in both therapeutic and chemical biology contexts. Covalent reactive groups (CRGs) typically engage nucleophilic residues such as cysteine, resulting in targeted protein inactivation. However, common electrophiles such as acrylamides often suffer from nonselective reactivity, leading to off-target effects and toxicity. To overcome these limitations, we developed a modular sulfur(IV) reagent platform f...