6809期

最新文章

• Brazil's environmental governance at risk AI翻译
  作者：Cianciaruso, Marcus V.; Bini, Luis Mauricio; Diniz-Filho, Jose Alexandre; Loyola, Rafael
  作者单位：Universidade Federal de Goias
• Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease-linked transcription factor AI翻译
  作者：Grant, Zoe L.; Kuang, Shuzhen; Zhang, Shu; Horrillo, Abraham J.; Chen, Zhe; Rao, Kavitha S.; Celen, Cemre; Kameswaran, Vasumathi; Joubran, Carine; Lau, Pik Ki; Dong, Keyi; Yang, Bing; Bartosik, Weronika M.; Zemke, Nathan R.; Ren, Bing; Srivastava, Deepak; Kathiriya, Irfan S.; Pollard, Katherine S.; Bruneau, Benoit G.
  作者单位：University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell type-specific gene regulation is linked to the reorganization of three-dimensional (3D) chromatin during cellular differentiation. In this work, we show dose-dependent regulation of chromatin organization by the congenital heart disease (CHD)-linked, lineage-restricted TF TBX5 in human cardiomyocyte differentiation. Genome organization, including compartments, topologically ...
• The global biogeography of passerine songs AI翻译
  作者：Bacquele, Quentin; Barnagaud, Jean-Yves; Violle, Cyrille; Theunissen, Frederic; Mathevon, Nicolas
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Jean Monnet; Universite Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier; University of California System; University of California Berkeley; Universite PSL; Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Ecole Pratique des Hautes Etudes (EPHE); Institut Universitaire de France
  摘要：Although bird songs are classic models for understanding the evolution of vocal communication, their global diversity has long made the development of a unifying framework challenging. By analyzing the acoustic architecture of songs from more than 3000 passerine species worldwide, we show that this acoustic space can be structured around eight elemental motifs. The differential use of these motifs is driven by a combination of species' biological traits (social organization, morphology, and ma...
• Spatially resolving the cone of reaction for a single molecule AI翻译
  作者：Timm, Matthew James; Matej, Adam; Gazizullin, Ilias; Chen, Qifan; Hecht, Stefan; Jelinek, Pavel; Grill, Leonhard
  作者单位：University of Graz; Czech Academy of Sciences; Institute of Physics of the Czech Academy of Sciences; Palacky University Olomouc; Charles University Prague; Humboldt University of Berlin; Humboldt University of Berlin
  摘要：Collisions of atoms and molecules are required for bond formation and are thus key to any chemical reaction. Their outcome is determined by the collision energy, relative orientation, and impact parameter of the reactants. Collision studies in the gas phase have shown that energies are easily controlled, whereas it is difficult to steer the molecular orientations and completely impossible to control the impact parameter. Here, we study the collision of individual molecules at a surface where e...
• Dispatches from the front lines of science AI翻译
  作者：Venkatraman, Vijaysree
• Epigenetic and 3D genome reprogramming during the aging of the human hippocampus AI翻译
  作者：Zemke, Nathan R.; Lee, Seoyeon; Mamde, Sainath; Yang, Bing; Berchtold, Nicole; Garduno, B. Maximiliano; Indralingam, Hannah S.; Bartosik, Weronika M.; Lau, Pik Ki; Dong, Keyi; Hsu, Emily; Yang, Amanda; Tani, Yasmine; Chen, Chumo; Zeng, Qiurui; Ajith, Varun; Tong, Liqi; Seng, Chanrung; Li, Daofeng; Wang, Ting; Zhou, Jingtian; Ecker, Joseph R.; Glass, Christopher K.; Cotman, Carl W.; Xu, Xiangmin; Ren, Bing
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California Irvine; University of Southern California; University of Southern California; Washington University (WUSTL); Washington University (WUSTL); Salk Institute; Salk Institute; Howard Hughes Medical Institute; University of California System; University of California San Diego; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital
  摘要：Changes in gene expression have been observed in the aging human brain, but our understanding of the underlying regulatory mechanisms remains limited. To unravel these complexities, we analyzed single-nucleus gene expression, chromatin accessibility, DNA methylation, and three-dimensional (3D) chromatin architecture from human hippocampal tissues spanning the adult lifespan. We identified both linear and nonlinear dynamic gene regulatory programs during aging. Between the ages of 50 to 75, emb...
• A tiny cone of reactivity AI翻译
  作者：Bjork, Jonas
  作者单位：Linkoping University
• Ballooning under water AI翻译
  作者：Harrison, Jon F.; Woods, H. Arthur
  作者单位：Arizona State University; Arizona State University-Tempe; University of Montana System; University of Montana
• A geologist learns AI AI翻译
  作者：Pope, Isaac
  作者单位：University of Missouri System; Missouri University of Science & Technology
• Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease AI翻译
  作者：Zhang, Yang; Lu, Xinyue; Kunisky, Alexander K.; Alam, Shahul; Tang, Junjie; Zhang, Ruochi; Wang, Shike; Zhang, Han; Baroudi, Jude; Ichcho, Walid; Jia, Deyong; Ghorbanikalateh, Sahar; Ghorbanikalateh, Sahel; Wang, Shihan; Bennett, David A.; Mathys, Hansruedi; Duan, Zhijun; Ma, Jian
  作者单位：Carnegie Mellon University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Los Angeles; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Rush University; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center
  摘要：Alzheimer's disease (AD) disrupts brain function through cell type-specific transcriptomic and epigenomic alterations, yet the contribution of three-dimensional (3D) genome organization to AD remains poorly understood. We applied GAGE-seq (genome architecture and gene expression by sequencing) to jointly profile gene expression and 3D chromatin structure in single cells from postmortem brain tissue from AD patients and age-matched individuals without AD, revealing chromatin reorganization link...