作者：Rangel-Buitrago, Nelson
作者：Sorkhabi, Rasoul
作者单位：Utah System of Higher Education; University of Utah
作者：Kandyba, Eve; Jabouille, Arnaud; Calvet, Ferriol; Li, Yun Rose; Curtabbi, Andrea; Cristea, Diana; Shin, Joyce; Delrosario, Reyno; Anzules, Jonathan; Wu, Di; Quigley, David; Taylor, Mark; Zanette, Camila; Lo, Fang Yin; Higgins, Jacob; Salk, Jesse; Lopez-Bigas, Nuria; Balmain, Allan
作者单位：University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; City of Hope; Translational Genomics Research Institute; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; Pompeu Fabra University; ICREA
摘要：The identification of the cancer cell of origin is a fundamental issue in cancer biology. We used fluorescent lineage tracing of independent mouse skin stem cell populations, single-cell transcriptomics, and duplex sequencing to identify the origin of chemically induced skin tumors. Tumors arose predominantly from Lgr6+ and/or Lrig1+ stem cells of the upper hair follicle but only very rarely from the Lgr5+ and Krt19+ hair follicle bulge. Lgr6+ stem cells initiated by dimethylbenzanthracene res...
