6814期

最新文章

• NASA's Roman telescope readies a sweeping view of the universe AI翻译
  作者：Clery, Daniel
• The worst energy policy in the world AI翻译
  作者：Mahdavi, Paasha; Ross, Michael L.
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
• Iron-catalyzed [1+1+1] cyclopropanation by sequential coupling of an ester to two carbenes AI翻译
  作者：Kong, Lingran; Zong, Kevin; Hopfengaertner, Marcus; Orzolek, Brandon J.; Shenvi, Ryan
  作者单位：Scripps Research Institute; Scripps Research Institute; University of Erlangen Nuremberg; Scripps Research Institute
  摘要：Traditional precious metal catalysis benefits from well-characterized inner-sphere elementary steps in which a single complex binds and unites substrates at the metal center. By contrast, base metal catalysts have recently demonstrated competence in cross-coupling transformations through iterative outer-sphere reactions in which product bond formation occurs by serial additions to the ligand, not the metal. Despite the emerging diversity of two-component outer-sphere reactions, comparable mult...
• A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease AI翻译
  作者：Pang, Jiyi; Al-Ani, Aysha H.; Patel, Komal M.; Zhou, Yunzhuo; Young, Samuel N.; Chen, Jinjin; Kong, Isabella; Barrios, Marilou; Rickard, James A.; Chen, Siqi; Ma, Xiuquan; Shojaee, Farzaneh; Kim, Seong-Beom; Foroughi, Siavash; Cawthorne, Wayne; Jacobsen, Annette V.; Jois, Asha; Weir, Ashley L.; Whitehead, Lachlan W.; Rajasekhar, Pradeep; Horne, Christopher R.; Lyu, Ruqian; Mather, Lucy J.; Yip, Raymond K. H.; Tsui, Ellen; Azeez, Imadh; Tan, Tao; Liang, Weiwei; Sivanesan, Suresh; Metz, Andrew; Patwardhan, Ash; Shea, Natalie; Iyngkaran, Guru; Schneider, Daniel; Elford, Alexander T.; Beattie, William; Macrae, Finlay; Liccardi, Gianmaria; Walczak, Henning; Zhang, Yuxia; Sieber, Oliver M.; Spelman, Tim; Giulino-Roth, Lisa; Christie, Michael; Chen, Yunshun; Rogers, Kelly L.; Bowden, Rory; Nicholson, Sandra E.; Lawlor, Kate E.; Hawkins, Edwin D.; Christensen, Britt; Samson, Andre L.; Vince, James E.; Murphy, James M.
  作者单位：Walter & Eliza Hall Institute; University of Melbourne; Melbourne Health; Royal Melbourne Hospital; University of Melbourne; Cornell University; Weill Cornell Medicine; Nankai University; Ulsan National Institute of Science & Technology (UNIST); Royal Children's Hospital Melbourne; Monash University; Guangzhou Medical University; Zhengzhou University; University of Cologne; University of Cologne; University of Cologne; University of London; University College London; Hudson Institute of Medical Research; Monash University
  摘要：Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Although current therapies aim to correct these imbalances to induce remission, most patients ultimately relapse, suggesting that key pathogenic mechanisms persist. Here, we identified aberrant epithelial cell death signaling as an underlying feature of IBD that arises in patients in remission and on advanced therapy. Mechanistically...
• Ordering atoms on weak interaction AI翻译
  作者：Shin, June-Chul; Kim, Jeehwan
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
• Autism mutations rewire protein interaction networks to drive neurodevelopmental pathology AI翻译
  作者：Wang, Belinda; Vartak, Rasika; Hennick, Kelsey M.; Zaltsman, Yefim; Naing, Zun Zar Chi; Polacco, Benjamin J.; Bashir, Ali; Eckhardt, Manon; Bouhaddou, Mehdi; Xu, Jiewei; Sun, Nawei; Lasser, Micaela C.; Zhou, Yuan; McKetney, Justin; Guiley, Keelan Z.; Gniewek, Pawel; Chan, Una; Amirani, Naufa; Griffiths, Owen; Chadha, Nishant; Tognatta, Reshmi; Cakir, Merve; Gordon, Martin; Khare, Prachi; Drake, Sam; Drury, Vanessa; Burke, David F.; Gonzalez, Silvano; Alkhairy, Sahar; Thomas, Reuben; Lam, Stephanie; Morris, Montana; Bader, Ethel; Dos Santos, Melanie; Komarova, Anastassia V.; Bennett, Maxwell; Ennis, Craig; Castillo, Octavio; Lim, Yvonne; Martin, Robert; Seyler, Meghan; Baum, Tierney; Krasnoff, Rebecca; Wang, George; Middya, Sagnik; Wang, Sheng; Pham, Presley; Arbelaez, Juan; Pratt, Dexter; Bali, Sofia; Chag, Shivali; Kaye, Julia A.; Mahmood, Nadir; Spraggon, Lee; Rolland, Thomas; Hervey-Jumper, Shawn; Fraser, James S.; Bourgeron, Thomas; Finkbeiner, Steven; Demeret, Caroline; Swaney, Danielle L.; Bandyopadhyay, Sourav; Ideker, Trey; Beltrao, Pedro; Willsey, Helen Rankin; Huttenhain, Ruth; Obernier, Kirsten; Nowakowski, Tomasz J.; State, Matthew W.; Willsey, A. Jeremy; Krogan, Nevan J.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; University of California System; University of California San Diego; Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of California System; University of California San Francisco; University of California System; University of California San Francisco; AstraZeneca; University of California System; University of California Los Angeles; Columbia University; New York University; Vanderbilt University; New York University; Stanford University
  摘要：Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease mechanisms and therapeutic opportunities. Using affinity purification-mass spectrometry, we systematically mapped PPIs for 100 high-confidence ASD genes, uncovering more than 1800 interactions. By assessing the impact of pathogenic missense mutations, leveraging AlphaFold, and validating key findi...
• A plea for public health support for war-torn El Obeid, Sudan AI翻译
  作者：Siddig, Emmanuel Edwar
  作者单位：University of Khartoum
• Beyond wrinkles Can the skin microbiome shape healthy aging? AI翻译
  作者：Jalili, Sasan; Oh, Julia
  作者单位：Jackson Laboratory; Duke University; Duke University; Duke University
• SGLT2 inhibitors activate pantothenate kinase in the human heart AI翻译
  作者：Forelli, Nicholas; Thome, Trace; Eaton, Deborah M.; Schultz, Kollin; Patel, Jiten; Bowman, Caitlyn E.; Kawakami, Ryo; Jung, Jae Woo; Kuznetsov, Ivan A.; Li, Kristina; Liang, Jialiu A.; Branch, Kirsten; Brady, Claire; Bedi Jr, Kenneth C.; Yang, Yijun; Koya, Kaustubh; Bouhrira, Nesrine; Megill, Emily; Kantner, Daniel S.; Smith, Louis G.; MacIntosh, Cristin F.; Gupta, Kushol; Bowman, Gregory R.; Snyder, Nathaniel W.; Edwards, Jonathan; Margulies, Kenneth B.; Arany, Zoltan
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine
  摘要：Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantothenate kinase 1 (PANK1), the rate-limiting enzyme in coenzyme A (CoA) synthesis. Using stable isotope infusions, we established that SGLT2i activate CoA synthesis and broadly stimulate fuel use in human cardiac tissue. We also demonstrated that SGLT2i bind PANK1 at physiological concentrations, direc...
• The knotty problem of RNA structure prediction AI翻译
  作者：Mustoe, Anthony M.; Guo, Junzhe
  作者单位：Baylor College of Medicine