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作者：Carmichael, Iain; Calhoun, Benjamin C.; Hoadley, Katherine A.; Troester, Melissa A.; Geradts, Joseph; Couture, Heather D.; Olsson, Linnea; Perou, Charles M.; Niethammer, Marc; Hannig, Jan; Marron, J. S.
作者单位：University of Washington; University of Washington Seattle; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; East Carolina University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要：The two main approaches in the study of breast cancer are histopathology (analyzing visual characteristics of tumors) and genomics. While both histopathology and genomics are fundamental to cancer research, the connections between these fields have been relatively superficial. We bridge this gap by investigating the Carolina Breast Cancer Study through the development of an integrative, exploratory analysis framework. Our analysis gives insights-some known, some novel-that are engaging to both...
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作者：D'Angelo, Silvia; Brennan, Lorraine; Gormley, Isobel Claire
作者单位：University College Dublin; University College Dublin
摘要：Metabolomic-based approaches have gained much attention in recent years, due to their promising potential to deliver objective tools for assessment of food intake. In particular, multiple biomarkers have emerged for single foods. However, there is a lack of statistical tools available for combining multiple biomarkers to quantitatively infer food intake. Furthermore, there is a paucity of approaches for estimating the uncertainty around biomarker-based inferred intake. Here, to estimate the re...
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作者：Hoeltgebaum, Henrique; Adams, Niall; Lau, F. Din-Houn
作者单位：Imperial College London
摘要：Structural health monitoring (SHM) often involves instrumenting structures with distributed sensor networks. These networks typically provide high frequency data describing the spatiotemporal behaviour of the assets. A main objective of SHM is to reason about changes in structures' behaviour using sensor data. We construct a streaming anomaly detection method for data from a railway bridge instrumented with a fibre-optic sensor network. The data exhibits trend over time, which may be partially...
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作者：Pfister, Niklas; Williams, Evan G.; Peters, Jonas; Aebersold, Ruedi; Buehlmann, Peter
作者单位：University of Copenhagen; University of Luxembourg; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：We consider regression in which one predicts a response Y with a set of predictors X across different experiments or environments. This is a common setup in many data-driven scientific fields, and we argue that statistical inference can benefit from an analysis that takes into account the distributional changes across environments. In particular, it is useful to distinguish between stable and unstable predictors, that is, predictors which have a fixed or a changing functional dependence on the...
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作者：McLain, Alexander C.; Guo, Siyuan; Thoma, Marie; Zhang, Jiajia
作者单位：University of South Carolina System; University of South Carolina Columbia; University System of Maryland; University of Maryland College Park
摘要：Cross-sectional length-biased data arise from questions on the at-risk time for an event of interest from those who are at risk but have yet to experience the event. For example, in the National Survey on Family Growth (NSFG) women, who were currently attempting to become pregnant, were asked how long they had been attempting pregnancy. Cross-sectional survival analysis methods use the observed at-risk times to make inference on the distribution of the unobserved time-to-failure. However, meth...
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作者：Li, Cai; Zhang, Heping
作者单位：Yale University
摘要：Human intelligence is usually measured by well-established psychometric tests through a series of problem solving. The recorded cognitive scores are continuous but usually heavy-tailed with potential outliers and violating the normality assumption. Meanwhile, magnetic resonance imaging (MRI) provides an unparalleled opportunity to study brain structures and cognitive ability. Motivated by association studies between MRI images and human intelligence, we propose a tensor quantile regression mod...
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作者：Hunt, Gregory J.; Gagnon-Bartsch, Johann A.
作者单位：University of Michigan System; University of Michigan
摘要：Complex tissues are composed of a large number of different types of cells, each involved in a multitude of biological processes. Consequently, an important component to understanding such processes is understanding the cell-type composition of the tissues. Estimating cell-type composition using high-throughput gene expression data is known as cell-type deconvolution. In this paper we first summarize the extensive deconvolution literature by identifying a common regression-like approach to dec...
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作者：Gabitto, Mariano, I; Marie-Nelly, Herve; Pakman, Ari; Pataki, Andras; Darzacq, Xavier; Jordan, Michael, I
作者单位：Simons Foundation; Flatiron Institute; Stanford University; Li Ka Shing Center; University of California System; University of California Berkeley; Columbia University; Columbia University; University of California System; University of California Berkeley
摘要：We consider the problem of single-molecule identification in super-resolution microscopy. Super-resolution microscopy overcomes the diffraction limit by localizing individual fluorescing molecules in a field of view. This is particularly difficult since each individual molecule appears and disappears randomly across time and because the total number of molecules in the field of view is unknown. Additionally, data sets acquired with super-resolution microscopes can contain a large number of spu...
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作者：Ng, Tin Lok James; Murphy, Thomas Brendan; Westling, Ted; McCormick, Tyler H.; Fosdick, Bailey
作者单位：Trinity College Dublin; University College Dublin; University of Massachusetts System; University of Massachusetts Amherst; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Colorado State University System; Colorado State University Fort Collins
摘要：Dail Eireann is the principal chamber of the Irish parliament. The 31st Dail was in session from March 11th, 2011 to February 6th, 2016. Many of the members of the Dail were active on social media, and many were Twitter users who followed other members of the Dail. The pattern of Twitter following amongst these politicians provides insights into political alignment within the Dail. We propose a new model, called the generalized latent space stochastic blockmodel, which extends and generalizes ...
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作者：Hadj-Amar, Beniamino; Finkenstadt, Barbel; Fiecas, Mark; Huckstepp, Robert
作者单位：University of Warwick; University of Minnesota System; University of Minnesota Twin Cities; University of Warwick
摘要：We propose to model time-varying periodic and oscillatory processes by means of a hidden Markov model where the states are defined through the spectral properties of a periodic regime. The number of states is unknown along with the relevant periodicities, the role and number of which may vary across states. We address this inference problem by a Bayesian nonparametric hiddenMarkov model, assuming a sticky hierarchical Dirichlet process for the switching dynamics between different states while ...
