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作者：Erciulescu, Andreea L.; Opsomer, Jean D.; Breidt, F. Jay
作者单位：Westat; Colorado State University System; Colorado State University Fort Collins
摘要：Surveys designed to collect data on similar variables using samples representing the same population may still result in different estimates due, for example, to differences in sample designs or modes of data collection. Considered in this paper is the case where two surveys were conducted concurrently, with one using the same methodology as used in prior rounds of the survey and the other using an updated methodology, resulting in substantial differences in several key estimates. Due to diffe...
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作者：Dong, Tracy Qi; Wakefield, Jon
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Despite substantial advances in global measles vaccination, measles disease burden remains high in many low- and middle-income countries. A key public health strategy for controlling measles in such high-burden settings is to conduct supplementary immunization activities (SIAs) in the form of mass vaccination campaigns, in addition to delivering scheduled vaccination through routine immunization (RI) programs. To achieve balanced implementations of RI and SIAs, robust measurement of subnationa...
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作者：Zemplenyi, Michele; Meyer, Mark J.; Cardenas, Andres; Hivert, Marie-France; Rifas-Shiman, Sheryl L.; Gibson, Heike; Kloog, Itai; Schwartz, Joel; Oken, Emily; DeMeo, Dawn L.; Gold, Diane R.; Coull, Brent A.
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Georgetown University; University of California System; University of California Berkeley; Harvard University; Harvard Medical School; Harvard University; Harvard T.H. Chan School of Public Health; Ben-Gurion University of the Negev; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital
摘要：The ability to identify time periods when individuals are most susceptible to exposures as well as the biological mechanisms through which these exposures act is of great public health interest. Growing evidence supports an association between prenatal exposure to air pollution and epigenetic marks, such as DNA methylation, but the timing and gene-specific effects of these epigenetic changes are not well understood. Here, we present the first study that aims to identify prenatal windows of sus...
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作者：Jernigan, Robert; Jia, Kejue; Ren, Zhao; Zhou, Wen
作者单位：Iowa State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Colorado State University System; Colorado State University Fort Collins
摘要：Measuring the dependence of k >= 3 random variables and drawing inference from such higher-order dependences are scientifically important yet challenging. Motivated here by protein coevolution with multivariate categorical features, we consider an information theoretic measure of higher-order dependence. The proposed collective dependence is a symmetrization of differential interaction information which generalizes the mutual information of a pair of random variables. We show that the collecti...
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作者：Molstad, Aaron J.; Sun, Wei; Hsu, Li
作者单位：State University System of Florida; University of Florida; Fred Hutchinson Cancer Center
摘要：Transcriptome-wide association studies based on genetically predicted gene expression have the potential to identify novel regions associated with various complex traits. It has been shown that incorporating expression quantitative trait loci (eQTLs) corresponding to multiple tissue types can improve power for association studies involving complex etiology. In this article we propose a new multivariate response linear regression model and method for predicting gene expression in multiple tissu...
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作者：Zhang, Rong; Ren, Zhao; Celedon, Juan C.; Chen, Wei
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Recent advances in next-generation sequencing technology have yielded huge amounts of transcriptomic data. The discreteness and the high dimensions of RNA-seq data have posed great challenges in biological network analysis. Although estimation theories for high-dimensional modified Poisson-type graphical models have been proposed for the network analysis of count-valued data, the statistical inference of these models is still largely unknown. We herein propose a two-step procedure in both edge...
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作者：Glynn, Chris; Tokdar, Surya T.; Zaman, Azeem; Caruso, Valeria C.; Mohl, Jeff T.; Willett, Shawn M.; Groh, Jennifer M.
作者单位：Duke University; Harvard University; University of Michigan System; University of Michigan; Duke University; Duke University
摘要：Conventional analysis of neuroscience data involves computing average neural activity over a group of trials and/or a period of time. This approach may be particularly problematic when assessing the response patterns of neurons to more than one simultaneously presented stimulus. In such cases the brain must represent each individual component of the stimuli bundle, but trial-and-time-pooled averaging methods are fundamentally unequipped to address the means by which multiitem representation oc...
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作者：Shan, Mingyang; Thomas, Kali S.; Gutman, Roee
作者单位：Brown University; Brown University
摘要：Causal analysis of observational studies requires data that comprise a set of covariates, a treatment assignment indicator and the observed outcomes. However, data confidentiality restrictions or the nature of data collection may distribute these variables across two or more datasets. In the absence of unique identifiers to link records across files, probabilistic record linkage algorithms can be leveraged to merge the datasets. Current applications of record linkage are concerned with estimat...
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作者：De Vito, Roberta; Bellio, Ruggero; Trippa, Lorenzo; Parmigiani, Giovanni
作者单位：Brown University; University of Udine; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard T.H. Chan School of Public Health
摘要：This paper analyzes breast cancer gene expression across seven studies to identify genuine and thus replicable gene patterns shared among these studies. Our premise is that genuine biological signal is more likely to be reproducibly present in multiple studies than spurious signal. Our analysis uses a new modeling strategy for the joint analysis of high-throughput biological studies which simultaneously identifies shared as well as study-specific signal. To this end, we generalize the multi-st...
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作者：Li, Shuoran; Ko, Young Myoung; Byon, Eunshin
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pohang University of Science & Technology (POSTECH); University of Michigan System; University of Michigan
摘要：Using aeroelastic stochastic simulations, this study presents an importance sampling method for assessing wind turbine reliability. As the size of modern wind turbines gets larger, structural reliability analysis becomes more important to prevent any catastrophic failures. At the design stage, operational data do not exist or are scarce. Therefore, aeroelastic simulation is often employed for reliability analysis. Importance sampling is one of the powerful variance reduction techniques to miti...
