The Annals of Applied Statistics

最新文章

• TESTING FOR THE CAUSAL MEDIATION EFFECTS OF MULTIPLE MEDIATORS USING THE KERNEL MACHINE DIFFERENCE METHOD IN GENOME-WIDE EPIGENETIC STUDIES AI翻译
  作者：Shen, Jincheng; Schwartz, Joel; Baccarelli, Andrea A.; Lin, Xihong
  作者单位：Utah System of Higher Education; University of Utah; Harvard University; Harvard T.H. Chan School of Public Health; Columbia University; Columbia University; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：The rapid growth of high -throughput genomic and epigenomic data enables exploration of biological mechanisms underlying diseases causing processes beyond traditional association studies. Using the causal mediation analysis framework, we develop the kernel machine difference (KMD) method, which provides a testing procedure for detecting the mediation effects of a set of mediators, for example, the DNA methylation probes within a region or a gene. Our method extends the difference method in sin...
• ONLINE MONITORING OF AIR QUALITY USING PCA-BASED SEQUENTIAL LEARNING AI翻译
  作者：Xie, Xiulin; Qian, Nicole; Qiu, Peihua
  作者单位：State University System of Florida; Florida State University; Northwestern University; State University System of Florida; University of Florida
  摘要：Air pollution surveillance is critically important for public health. One air pollutant, ozone, is extremely challenging to analyze properly, as it is a secondary pollutant caused by complex chemical reactions in the air and does not emit directly into the atmosphere. Numerous environmental studies confirm that ozone concentration levels are associated with meteorological conditions, and long-term exposure to high ozone concentration levels is associated with the incidence of many diseases, in...
• MODEL-ROBUST BAYESIAN DESIGN THROUGH GENERALISED ADDITIVE MODELS FOR MONITORING SUBMERGED SHOALS AI翻译
  作者：DE Silva, Dilishiya; Fisher, Rebecca; Radford, Ben; Hompson, Helen; Mcree, James
  作者单位：Queensland University of Technology (QUT); University of Western Australia; Australian Institute of Marine Science
  摘要：Optimal sampling strategies are critical for surveys of deeper coral reef and shoal systems due to the significant cost of accessing and field sampling these remote and poorly understood ecosystems. Additionally, wellestablished standard diver-based sampling techniques used in shallow reef systems are not feasible at greater depths. In this study, we develop a Bayesian design strategy to optimise sampling for a shoal deep reef system using three years of pilot data. Bayesian designs are typica...
• COMMUNICATION NETWORK DYNAMICS IN A LARGE ORGANIZATIONAL HIERARCHY AI翻译
  作者：Osephs, Athaniel; Eng, Ida; Rawford, Orrest w.
  作者单位：North Carolina State University; Microsoft; Yale University
  摘要：Most businesses impose a supervisory hierarchy on employees to faemployee communication patterns within workplaces tend to emerge more naturally as a consequence of both supervisory relationships and the needs of the organization. What then is the relationship between a formal organizational structure and the emergent communications between its employees? Understanding the nature of this relationship is critical for the successful management of an organization. While scholars of organizational...
• AN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY AI翻译
  作者：Dai, Wei; Zhang, Heping
  作者单位：Yale University
  摘要：Functional connectivity of the brain, characterized by interconnected neural circuits across functional networks, is a cutting-edge feature in neuroimaging. It has the potential to mediate the effect of genetic variants on behavioral outcomes or diseases. Existing mediation analysis methods can evaluate the impact of genetics and brain structure/function on cognitive behavior or disorders, but they tend to be limited to single genetic variants or univariate mediators, without considering cumul...
• LEARNING AND FORECASTING OF AGE-SPECIFIC PERIOD MORTALITY VIA B-SPLINE PROCESSES WITH LOCALLY-ADAPTIVE DYNAMIC COEFFICIENTS AI翻译
  作者：Pavone, Federico; Legramanti, Sirio; Durante, Daniele
  作者单位：Bocconi University; University of Bergamo
  摘要：Although the analysis of human mortality has a well-established history, the attempt to accurately forecast future death-rate patterns for different age groups and time horizons still attracts active research. Such a predictive focus has motivated an increasing shift toward more flexible representations of age-specific period mortality trajectories at the cost of reduced interpretability. Although this perspective has led to successful predictive strategies, the inclusion of interpretable stru...
• MULTISCALE POISSON PROCESS APPROACHES FOR DETECTING AND ESTIMATING DIFFERENCES FROM HIGH-THROUGHPUT SEQUENCING ASSAYS AI翻译
  作者：Shim, Heejung; Xing, Zhengrong; Pantaleo, Ester; Luca, Francesca; Pique-Regi, Roger; Stephens, Matthew
  作者单位：University of Melbourne; University of Chicago; Wayne State University; Wayne State University; Wayne State University; University of Chicago
  摘要：Estimating and testing for differences in molecular phenotypes (e.g., gene expression, chromatin accessibility, transcription factor binding) across conditions is an important part of understanding the molecular basis of gene regulation. These phenotypes are commonly measured using high-throughput high-resolution count data that reflect how the phenotypes vary along the genome. Multiple methods have been proposed to help exploit these highresolution measurements for differential expression ana...
• SEMIPARAMETRIC ESTIMATION FOR DYNAMIC NETWORKS WITH SHIFTED CONNECTING INTENSITIES AI翻译
  作者：Zhang, Zitong; Chen, Shizhe
  作者单位：University of California System; University of California Davis
  摘要：Neural circuits are of paramount importance in the nervous system, as they are the essential infrastructure in guiding animal behavior. However, modeling the development of neural circuits poses significant challenges due to inherent properties of the development process. First, the neural circuit development process is transient, where the course of development can only be observed once. Second, despite potentially sharing similar underlying mechanisms for development, neural circuits from di...
• BAYESIAN NESTED LATENT CLASS MODELS FOR CAUSE-OF-DEATH ASSIGNMENT USING VERBAL AUTOPSIES ACROSS MULTIPLE DOMAINS AI翻译
  作者：Li, Zehang Richard; Wu, Zhenke; Chen, Irena; Clark, Samuel J.
  作者单位：University of California System; University of California Santa Cruz; University of Michigan System; University of Michigan; Max Planck Society; University System of Ohio; Ohio State University
  摘要：Understanding cause-specific mortality rates is crucial for monitoring population health and designing public health interventions. Worldwide, twothirds of deaths do not have a cause assigned. Verbal autopsy (VA) is a wellestablished tool to collect information describing deaths outside of hospitals by conducting surveys to caregivers of a deceased person. It is routinely implemented in many low- and middle-income countries. Statistical algorithms to assign cause of death using VAs are typical...
• HIERARCHICAL DEPENDENCE MODELING FOR THE ANALYSIS OF LARGE INSURANCE CLAIMS DATA AI翻译
  作者：Ma, Ting Fung; Cai, Yizhou; Shi, Peng; Zhu, Jun
  作者单位：University of South Carolina System; University of South Carolina Columbia; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
  摘要：Extreme weather events associated with climate change have caused significant damages. In particular, hail storms damage millions of properties in the U.S. and result in billion-dollar insured losses each year in the recent decade. To facilitate the insurance claims management operations in insurance companies, we construct a hierarchical dependence model, which accommodates the complex dependence within and between the outcomes of interests including the propensity of filing a claim, time to ...