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作者：Ashokan, Akash; Sarkar, Shrita; Kamran, Mohammad Z.; Surnar, Bapurao; Kalathil, Akil A.; Spencer, Alexis; Dhar, Shanta
作者单位：University of Miami; University of Miami; University of Miami
摘要：Brain metastasis of advanced breast cancer often results in deleterious consequences. Metastases to the brain lead to significant challenges in treatment options, as the blood- brain barrier (BBB) prevents conventional therapy. Thus, we hypothesized that creation of a nanoparticle (NP) that distributes to both primary tumor site and across the BBB for secondary brain tumor can be extremely beneficial. Here, we report a simple targeting strategy to attack both the primary breast and secondary b...
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作者：Fromm, Katja; Ortelli, Monica; Boegli, Alexandra; Dehio, Christoph
作者单位：University of Basel; University of Lausanne
摘要：The evolutionary conserved YopJ family comprises numerous type- III- secretion system (T3SS) effectors of diverse mammalian and plant pathogens that acetylate host proteins to dampen immune responses. Acetylation is mediated by a central acetyltransferase domain that is flanked by conserved regulatory sequences, while a nonconserved N- terminal extension encodes the T3SS- specific translocation signal. Bartonella spp. are facultative- intracellular pathogens causing intraerythrocytic bacteremi...
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作者：Maloney, Ashley E.; Kopf, Sebastian H.; Zhang, Zhaoyue; Mcfarlin, Jamie; Nelson, Daniel B.; Masterson, Andrew L.; Zhang, Xinning
作者单位：Princeton University; University of Colorado System; University of Colorado Boulder; Princeton University; Princeton University; University of Wyoming; University of Basel; Northwestern University; Princeton University
摘要：Shifts in the hydrogen stable isotopic composition (H-2/H-1 ratio) of lipids relative to water (lipid/water H-2-fractionation) at natural abundances reflect different sources of the central cellular reductant, NADPH, in bacteria. Here, we demonstrate that lipid/water H-2-fractionation ((2)epsilon(fattyacid/water)) can also constrain the relative importance of key NADPH pathways in eukaryotes. We used the metabolically flexible yeast Saccharomyces cerevisiae, a microbial model for respiratory a...
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作者：Marshall, Adrienne M.; Abatzoglou, John T.; Rahimi, Stefan; Lettenmaier, Dennis P.; Hall, Alex
作者单位：Colorado School of Mines; University of California System; University of California Merced; University of Wyoming; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：The increasing prevalence of low snow conditions in a warming climate has attracted substantial attention in recent years, but a focus exclusively on low snow leaves high snow years relatively underexplored. However, these large snow years are hydrologically and economically important in regions where snow is critical for water resources. Here, we introduce the term snow deluge and use anomalously high snowpack in California's Sierra Nevada during the 2023 water year as a case study. Snow moni...
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作者：[Anonymous]
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作者：McDermott, Amy
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作者：Chuey, Aaron; Luo, Yiwei; Markman, Ellen M.
作者单位：Stanford University; Stanford University
摘要：How we reason about objectivity-whether an assertion has a ground truth-has implications for belief formation on wide - ranging topics. For example, if someone perceives climate change to be a matter of subjective opinion similar to the best movie genre, they may consider empirical claims about climate change as mere opinion and irrelevant to their beliefs. Here, we investigate whether the language employed by journalists might influence the perceived objectivity of news claims. Specifically, ...
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作者：Zhao, Yang
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
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作者：Kohram, Maryam; Sanderson, Amy E.; Loui, Alicia; Thompson, Peyton V.; Vashistha, Harsh; Shomar, Aseel; Oltvai, Zoltan N.; Salman, Hanna
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Technion Israel Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Rochester; Princeton University; Yale University
摘要：Random mutagenesis, including when it leads to loss of gene function, is a key mechanism enabling microorganisms' long - term adaptation to new environments. However, lossof - function mutations are often deleterious, triggering, in turn, cellular stress and complex homeostatic stress responses, called allostasis, to promote cell survival. Here, we characterize the differential impacts of 65 nonlethal, deleterious single - gene deletions on Escherichia coli growth in three different growth env...
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作者：Natarajan, Lawanya; De Sciscio, Maria Laura; Nardi, Alessandro Nicola; Sekhar, Ashok; Del Giudice, Alessandra; D'Abramo, Marco; Naganathan, Athi N.
作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Sapienza University Rome
摘要：TipA, a MerR family transcription factor from Streptomyces lividans , promotes antibiotic resistance by sequestering broad - spectrum thiopeptide - based antibiotics, thus counteracting their inhibitory effect on ribosomes. TipAS, a minimal binding motif which is expressed as an isoform of TipA, harbors a partially disordered N - terminal subdomain that folds upon binding multiple antibiotics. The extent and nature of the underlying molecular heterogeneity in TipAS that shapes its promiscuous ...
