20期

最新文章

• A vasopressin circuit that modulates mouse social investigation and anxiety- like behavior in a sex- specific manner AI翻译
  作者：Rigney, Nicole; Campos-Lira, Elba; Kirchner, Matthew K.; Wei, Wei; Belkasim, Selma; Beaumont, Rachael; Singh, Sumeet; Suarez, Sara Guedez; Hartswick, Delenn; Stern, Javier E.; de Vries, Geert J.; Petrulis, Aras
  作者单位：University System of Georgia; Georgia State University
  摘要：One of the largest sex differences in brain neurochemistry is the expression of the neuropeptide arginine vasopressin (AVP) within the vertebrate brain, with males having more AVP cells in the bed nucleus of the stria terminalis (BNST) than females. Despite the long - standing implication of AVP in social and anxietylike behaviors, the circuitry underlying AVP's control of these behaviors is still not well defined. Using optogenetic approaches, we show that inhibiting AVP BNST cells reduces so...
• A TME- enlightened protein- binding photodynamic nanoinhibitor for highly effective oncology treatment AI翻译
  作者：Cui, Zepeng; Huang, Baoxuan; Zheng, Jiahao; Tian, Jia; Zhang, Weian
  作者单位：East China University of Science & Technology; East China University of Science & Technology
  摘要：The efficiency of photodynamic therapy (PDT) is greatly dependent on intrinsic features of photosensitizers (PSs), but most PSs suffer from narrow diffusion distances and short life span of singlet oxygen ( 1 O 2 ). Here, to conquer this issue, we propose a strategy for in situ formation of complexes between PSs and proteins to deactivate proteins, leading to highly effective PDT. The tetrafluorophenyl bacteriochlorin (FBC), a strong near - infrared absorbing photosensitizer, can tightly bind ...
• Three- dimensional architecture of ESCRT- III flat spirals on the membrane AI翻译
  作者：Liu, Mingdong; Liu, Yunhui; Song, Tiefeng; Yang, Liuyan; Qi, Lei; Zhang, Yu- Zhong; Wang, Yong; Abcd, Qing- Tao Shen
  作者单位：Southern University of Science & Technology; Southern University of Science & Technology; ShanghaiTech University; ShanghaiTech University; Zhejiang University; Shandong University; Shandong University
  摘要：The endosomal sorting complexes required for transport (ESCRTs) are responsible for membrane remodeling in many cellular processes, such as multivesicular body biogenesis, viral budding, and cytokinetic abscission. ESCRT- III, the most abundant ESCRT subunit, assembles into flat spirals as the primed state, essential to initiate membrane invagination. However, the three- dimensional architecture of ESCRT- III flat spirals remained vague for decades due to highly curved filaments with a small d...
• Point mutation in a virus- like capsid drives symmetry reduction to form tetrahedral AI翻译
  作者：Szyszka, Taylor N.; Andreas, Micheal P.; Lie, Felicia; Miller, Lohra M.; Adamson, Lachlan S. R.; Fatehi, Farzad; Twarock, Reidun; Draper, Benjamin E.; Jarrold, Martin F.; Giessen, Tobias W.; Lau, Yu Heng
  作者单位：University of Sydney; University of Sydney; University of Michigan System; University of Michigan; Indiana University System; Indiana University Bloomington; University of York - UK; University of York - UK; University of York - UK
  摘要：Protein capsids are a widespread form of compartmentalization in nature. Icosahedral symmetry is ubiquitous in capsids derived from spherical viruses, as this geometry maximizes the internal volume that can be enclosed within. Despite the strong preference for icosahedral symmetry, we show that simple point mutations in a virus - like capsid can drive the assembly of unique symmetry - reduced structures. Starting with the encapsulin from Myxococcus xanthus , a 180 - mer bacterial capsid that a...
• Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx- mediated resistance to HER2targeting therapies AI翻译
  作者：Goyette, Marie-Anne; Stevens, Laura E.; Depinho, Carolyn R.; Seehawer, Marco; Nishida, Jun; Li, Zheqi; Wilde, Callahan M.; Li, Rong; Qiu, Xintao; Pyke, Alanna L.; Zhao, Stephanie; Lim, Klothilda; Tender, Gabrielle S.; Northey, Jason J.; Riley, Nicholas M.; Long, Henry W.; Bertozzi, Carolyn R.; Weaver, Valerie M.; Polyak, Kornelia
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Stanford University; University of California System; University of California San Francisco; Howard Hughes Medical Institute; Stanford University; Stanford University; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Brain metastatic breast cancer is particularly lethal largely due to therapeutic resistance. Almost half of the patients with metastatic HER2positive breast cancer develop brain metastases, representing a major clinical challenge. We previously described that cancer - associated fibroblasts are an important source of resistance in primary tumors. Here, we report that breast cancer brain metastasis stromal cell interactions in 3D cocultures induce therapeutic resistance to HER2targeting agents,...
• Reply to Vogt et al.: What does it mean that a phenomenon generalizes? AI翻译
  作者：Mazar, Nina; Elbaek, Christian T.; Mitkidis, Panagiotis
  作者单位：Boston University; Aarhus University
• Modular multi- degree- of- freedom soft origami robots with reprogrammable electrothermal actuation AI翻译
  作者：Wu, Shuang; Zhao, Tuo; Zhu, Yong; Paulino, Glaucio H.
  作者单位：North Carolina State University; Princeton University; Princeton University
  摘要：Soft robots often draw inspiration from nature to navigate different environments. Although the inching motion and crawling motion of caterpillars have been widely studied in the design of soft robots, the steering motion with local bending control remains challenging. To address this challenge, we explore modular origami units which constitute building blocks for mimicking the segmented caterpillar body. Based on this concept, we report a modular soft Kresling origami crawling robot enabled b...
• A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex AI翻译
  作者：Liang, Xiaoyi G.; Hoang, Kendy; Meyerink, Brandon L.; Pratiksha, Kc; Paraiso, Kitt; Wang, Li; Jones, Ian R.; Zhang, Yue; Katzman, Sol; Finn, Thomas S.; Tsyporin, Jeremiah; Qu, Fangyuan; Chen, Zhaoxu; Visel, Axel; Kriegstein, Arnold; Shen, Yin; Pilaz, Louis - Jan; Chen, Bin
  作者单位：University of California System; University of California Santa Cruz; Sanford Health; Sanford Health; University of South Dakota; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Santa Cruz; United States Department of Energy (DOE); Joint Genome Institute - JGI; University of California System; University of California Merced; Zhejiang University; Liangzhu Laboratory; Zhejiang University
  摘要：During development, neural stem cells in the cerebral cortex, also known as radial glial cells (RGCs), generate excitatory neurons, followed by production of cortical macroglia and inhibitory neurons that migrate to the olfactory bulb (OB). Understanding the mechanisms for this lineage switch is fundamental for unraveling how proper numbers of diverse neuronal and glial cell types are controlled. We and others recently showed that Sonic Hedgehog (Shh) signaling promotes the cortical RGC lineag...
• A high- fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN- MDSC differentiation AI翻译
  作者：Chen, Jiewen; Liu, Xiyuan; Zou, Yi; Gong, Junli; Ge, Zhenhuang; Lin, Xiaorong; Zhang, Wei; Huang, Hongyan; Zhao, Jianli; Saw, Phei Er; Lu, Yongjun; Hu, Hai; Song, Erwei
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Southern Medical University - China; Sun Yat Sen University; Sun Yat Sen University; Southern Medical University - China
  摘要：A high - fat diet (HFD) is a high - risk factor for the malignant progression of cancers through the disruption of the intestinal microbiota. However, the role of the HFDrelated gut microbiota in cancer development remains unclear. This study found that obesity and obesity - related gut microbiota were associated with poor prognosis and advanced clinicopathological status in female patients with breast cancer. To investigate the impact of HFDassociated gut microbiota on cancer progression, we ...
• Modeling homologous chromosome recognition via nonspecific interactions AI翻译
  作者：Marshall, Wallace F.; Fung, Jennifer C.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：In many organisms, most notably Drosophila , homologous chromosomes associate in somatic cells, a phenomenon known as somatic pairing, which takes place without double strand breaks or strand invasion, thus requiring some other mechanism for homologs to recognize each other. Several studies have suggested a specific button model, in which a series of distinct regions in the genome, known as buttons, can associate with each other, mediated by different proteins that bind to these different regi...