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作者：Shi, Yanan; Morgan, Jason P.
作者单位：Southern University of Science & Technology
摘要：Delamination of the continental lithospheric mantle is well recorded beneath several continents. However, the fate of the removed continental lithosphere has been rarely noted, unlike subducted slabs reasonably well imaged in the upper and mid mantle. Beneath former Gondwana, recent seismic tomographic models indicate the presence of at least 5 horizontal fast- wavespeed anomalies at -600 km depths that do not appear to be related to slab subduction, including fast structures in locations cons...
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作者：Silberstein, John L.; Du, Jasper; Chan, Kun-Wei; Frank, Jessica A.; Mathews, Irimpan I.; Kim, Yong Bin; You, Jia; Lu, Qiao; Liu, Jia; Philips, Elliot A.; Liu, Phillip; Rao, Eric; Fernandez, Daniel; Rodriguez, Grayson E.; Kong, Xiang-Peng; Wang, Jun; Cochran, Jennifer R.
作者单位：Stanford University; Stanford University; New York University; New York University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University; Stanford University; New York University
摘要：Lymphocyte activation gene - 3 (LAG - 3) is an inhibitory receptor expressed on activated T cells and an emerging immunotherapy target. Domain 1 (D1) of LAG - 3, which has been purported to directly interact with major histocompatibility complex class II (MHCII) and fibrinogen-like protein 1 (FGL1), has been the major focus for the development of therapeutic antibodies that inhibit LAG - 3 receptor- ligand interactions and restore T cell function. Here, we present a high- resolution structure ...
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作者：Anderson, Jordan A.; Lin, Dana; Lea, Amanda J.; Johnston, Rachel A.; Voyles, Tawni; Akinyi, Mercy Y.; Archie, Elizabeth A.; Alberts, Susan C.; Tung, Jenny
作者单位：Duke University; Canadian Institute for Advanced Research (CIFAR); Vanderbilt University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Notre Dame; Duke University; Duke University; Max Planck Society
摘要：The early - life environment can profoundly shape the trajectory of an animal's life, even years or decades later. One mechanism proposed to contribute to these early - life effects is DNA methylation. However, the frequency and functional importance of DNA methylation in shaping early - life effects on adult outcomes is poorly understood, especially in natural populations. Here, we integrate prospectively collected data on fitness- associated variation in the early environment with DNA methyl...
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作者：Bouvier, Jacques W.; Emms, David M.; Kelly, Steven
作者单位：University of Oxford
摘要：Rubisco is the primary entry point for carbon into the biosphere. However, rubisco is widely regarded as inefficient leading many to question whether the enzyme can adapt to become a better catalyst. Through a phylogenetic investigation of the molecular and kinetic evolution of Form I rubisco we uncover the evolutionary trajectory of rubisco kinetic evolution in angiosperms. We show that rbcL is among the 1% of slowest- evolving genes and enzymes on Earth, accumulating one nucleotide substitut...
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作者：Chen, Jielin; Dai, Zheze; Lv, Hui; Jin, Zhongchao; Tang, Yuqing; Xie, Xiaodong; Shi, Jiye; Wang, Fei; Li, Qian; Liu, Xiaoguo; Fan, Chunhai
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Zhangjiang Laboratory; Chinese Academy of Sciences; Shanghai Institute of Applied Physics, CAS
摘要：Self- assembled DNA crystals offer a precise chemical platform at the angstrom-scale for DNA nanotechnology, holding enormous potential in material separation, catalysis, and DNA data storage. However, accurately controlling the crystallization kinetics of such DNA crystals remains challenging. Herein, we found that atomiclevel 5- methylcytosine (5mC) modification can regulate the crystallization kinetics of DNA crystal by tuning the hybridization rates of DNA motifs. We discovered that by man...
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作者：Haast, Roy A. M.; Kashyap, Sriranga; Ivanov, Dimo; Yousif, Mohamed D.; Dekraker, Jordan; Poser, Benedikt A.; Khan, Ali R.
作者单位：Western University (University of Western Ontario); University Western Ontario Hospital; Maastricht University; Krembil Research Institute; University of Toronto; University Health Network Toronto; McGill University
摘要：We present a comprehensive study on the non-invasive measurement of hippocampal perfusion. Using high-resolution 7 tesla arterial spin labeling (ASL) data, we generated robust perfusion maps and observed significant variations in perfusion among hippocampal subfields, with CA1 exhibiting the lowest perfusion levels. Notably, these perfusion differences were robust and already detectable with 50 perfusionweighted images per subject, acquired in 5 min. To understand the underlying factors, we ex...
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作者：Witten, Jacob; Hu, Yizong; Langer, Robert; Anderson, Daniel G.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Massachusetts Institute of Technology (MIT)
摘要：Nanoparticle- based RNA delivery has shown great progress in recent years with the approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV- 2) and a liver- targeted siRNA therapy. Here, we discuss the preclinical and clinical advancement of new generations of RNA delivery therapies along multiple axes. Improvements in cargo design such as RNA circularization and data- driven untranslated region optimization can drive better mRNA expression. New materials di...
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作者：Fuggetta, Nicolas; Rigolli, Nicola; Magdeleine, Maud; Hamai, Amazigh; Seminara, Agnese; Drin, Guillaume
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; Universite Paris Cite; University of Genoa
摘要：Oxysterol- binding protein- related proteins (ORPs) play key roles in the distribution of lipids in eukaryotic cells by exchanging sterol or phosphatidylserine for PI4P between the endoplasmic reticulum (ER) and other cell regions. However, it is unclear how their exchange capacity is coupled to PI4P metabolism. To address this question quantitatively, we analyze the activity of a representative ORP, Osh4p, in an ER/Golgi interface reconstituted with ER- and Golgi- mimetic membranes functional...
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作者：Ma, Rong; Sun, Eric D.; Donoho, David; Zou, James
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Stanford University; Stanford University
摘要：Single-cell data integration can provide a comprehensive molecular view of cells, and many algorithms have been developed to remove unwanted technical or biological variations and integrate heterogeneous single-cell datasets. Despite their wide usage, existing methods suffer from several fundamental limitations. In particular, we lack a rigorous statistical test for whether two high-dimensional single-cell datasets are alignable (and therefore should even be aligned). Moreover, popular methods...
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作者：Meng, Juanjuan
作者单位：Peking University
