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作者：Burtt, David G.; Stern, Jennifer C.; Webster, Christopher R.; Hofmann, Amy E.; Franz, Heather B.; Sutter, Brad; Thorpe, Michael T.; Kite, Edwin S.; Eigenbrode, Jennifer L.; Pavlov, Alexander A.; House, Christopher H.; Tutolo, Benjamin M.; Marais, David J. Des; Rampe, Elizabeth B.; Mcadam, Amy C.; Malespin, Charles A.
作者单位：National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); National Aeronautics & Space Administration (NASA); University of Chicago; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Calgary; National Aeronautics & Space Administration (NASA); NASA Ames Research Center
摘要：Carbonate minerals are of particular interest in paleoenvironmental research as they are an integral part of the carbon and water cycles, both of which are relevant to habitability. Given that these cycles are less constrained on Mars than they are on Earth, the identification of carbonates has been a point of emphasis for rover missions. Here, we present carbon (delta 13C) and oxygen (delta 18O) isotope data from four carbonates encountered by the Curiosity rover within the Gale crater. The c...
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作者：Feinberg, Aryeh; Selin, Noelle E.; Braban, Christine F.; Chang, Kai- Lan; Custodio, Danilo; Jaffe, Daniel A.; Kyllonen, Katriina; Landis, Matthew S.; Leeson, Sarah R.; Luke, Winston; Molepo, Koketso M.; Murovec, Marijana; Mastromonaco, Michelle G. Nerentorp; Pfaffhuber, Katrine Aspmo; Ruediger, Julian; Sheu, Guey- Rong; St. Louis, Vincent L.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); UK Centre for Ecology & Hydrology (UKCEH); University of Colorado System; University of Colorado Boulder; National Oceanic Atmospheric Admin (NOAA) - USA; Max Planck Society; University of Washington; University of Washington Bothell; University of Washington; University of Washington Seattle; Finnish Meteorological Institute; United States Environmental Protection Agency; National Oceanic Atmospheric Admin (NOAA) - USA; Helmholtz Association; Helmholtz-Zentrum Hereon; IVL Swedish Environmental Research Institute; NILU; National Central University; University of Alberta; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC)
摘要：Anthropogenic activities emit similar to 2,000 Mg y(-1) of the toxic pollutant mercury (Hg) into the atmosphere, leading to long- range transport and deposition to remote ecosystems. Global anthropogenic emission inventories report increases in Northern Hemispheric (NH) Hg emissions during the last three decades, in contradiction with the observed decline in atmospheric Hg concentrations at NH measurement stations. Many factors can obscure the link between anthropogenic emissions and atmospher...
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作者：Jones, Theresa M.; McNamara, Kathryn B.
作者单位：University of Melbourne
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作者：Kalinoski, Hannah; Daoud, Abdel; Rusinkevich, Vitali; Jurcova, Ivana; Talor, Monica V.; Welsh, Robin A.; Hughes, David; Zemanova, Katerina; Striz, Ilja; Hooper, Jody E.; Kautzner, Josef; Peichl, Petr; Melenovsky, Vojtech; Won, Taejoon; Cihakova, Daniela
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Institute for Clinical & Experimental Medicine (IKEM); Johns Hopkins University; Institute for Clinical & Experimental Medicine (IKEM); Stanford University; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Cardiac myosin- specific (MyHC) T cells drive the disease pathogenesis of immune checkpoint inhibitor-associated myocarditis (ICI- myocarditis). To determine whether MyHC T cells are tissue- resident memory T (TRM) cells, we characterized cardiac T RM cells in naive mice and established that they have a distinct phenotypic and transcriptional profile that can be defined by their upregulation of CD69, PD- 1, and CXCR6. We then investigated the effects of cardiac injury through a modified experi...
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作者：Liu, Aijun; Liu, Yezhou; Masachs, Claudia Llinas del Torrent; Zhang, Weijia; Pardo, Leonardo; Ye, Richard D.
作者单位：The Chinese University of Hong Kong, Shenzhen; Guangdong Medical University; Autonomous University of Barcelona; The Chinese University of Hong Kong, Shenzhen
摘要：Kaposi's sarcoma- associated herpesvirus (KSHV) encodes a viral G protein- coupled receptor, KSHV-GPCR, that contributes to KSHV immune evasion and pathogenesis of Kaposi's sarcoma. KSHV-GPCR shares a high similarity with CXC chemokine receptors CXCR2 and can be activated by selected chemokine ligands. Like other herpesvirus- encoded GPCRs, KSHV-GPCR is characterized by its constitutive activity by coupling to various G proteins. We investigated the structural basis of ligand- dependent and co...
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作者：Ma, Qizhao; Li, Jing; Yu, Shuxing; Zhou, Jing; Liu, Yaqi; Wang, Xinyue; Ye, Dingwei; Wu, Yumeng; Gong, Tao; Zhang, Qiong; Wang, Lingyun; Zou, Jing; Li, Yuqing
作者单位：Sichuan University; Sichuan University; Yale University; Sichuan University
摘要：Protein acetylation is a common and reversible posttranslational modification tightly governed by protein acetyltransferases and deacetylases crucial for various biological processes in both eukaryotes and prokaryotes. Although recent studies have characterized many acetyltransferases in diverse bacterial species, only a few protein deacetylases have been identified in prokaryotes, perhaps in part due to their limited sequence homology. In this study, we identified YkuR, encoded by smu_318, as...
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作者：Fitzgerald, Jack
作者单位：Vrije Universiteit Amsterdam
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作者：Kamra, Lina Johnsen; Lu, Bo; Linder, Jacob; Tanaka, Yukio; Nagaosa, Naoto
作者单位：Norwegian University of Science & Technology (NTNU); Autonomous University of Madrid; Autonomous University of Madrid; Massachusetts Institute of Technology (MIT); Tianjin University; Nagoya University; Nagoya University; RIKEN; RIKEN
摘要：The Majorana fermion offers fascinating possibilities such as non-Abelian statistics , nonlocal robust qubits , hunting it is one of the most important topics in current condensed matter physics. Most of the efforts have been focused on the Majorana bound state at zero energy in terms of scanning tunneling spectroscopy searching for the quantized conductance. On the other hand, a chiral Majorana edge channel appears at the surface of a three-dimensional topological insulator when engineering a...
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作者：Radhakrishnan, Harikrishnan; Newmyer, Sherri L.; Javitz, Harold S.; Bhatnagar, Parijat
作者单位：SRI International; SRI International
摘要：The CD4 T cell, when engineered with a chimeric antigen receptor (CAR) containing specific intracellular domains, has been transformed into a zero-order drug-delivery platform. This introduces the capability of prolonged, disease-specific engineered protein biologics production, at the disease site. Experimental findings demonstrate that CD4 T cells offer a solution when modified with a CAR that includes 4-1BB but excludes CD28 intracellular domain. In this configuration, they achieve similar ...
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作者：Kumar, Shruti; Bareke, Eric; Lee, Jimmy; Carlson, Emma; Merkuri, Fjodor; Schwager, Evelyn E.; Maglio, Steven; Fish, Jennifer L.; Majewski, Jacek; Jerome- Majewska, Loydie A.
作者单位：McGill University; McGill University; University of Massachusetts System; University of Massachusetts Lowell; McGill University; McGill University; McGill University
摘要：Pathogenic variants in SF3B4, a component of the U2 snRNP complex important for branchpoint sequence recognition and splicing, are responsible for the acrofacial disorders Nager and Rodriguez Syndrome, also known as SF3B4- related syndromes. Patients exhibit malformations in the head, face, limbs, vertebrae as well as the heart. To uncover the etiology of craniofacial malformations found in SF3B4- related syndromes, mutant mouse lines with homozygous deletion of Sf3b4 in neural crest cells (NC...
