2024

最新文章

• Increasing phosphorus loss despite widespread concentration decline in US rivers AI翻译
  作者：Zhi, Wei; Baniecki, Hubert; Liu, Jiangtao; Boyer, Elizabeth; Shen, Chaopeng; Shenk, Gary; Liu, Xiaofeng; Li, Li
  作者单位：Hohai University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Warsaw; Warsaw University of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; United States Department of the Interior; United States Geological Survey
  摘要：The loss of phosphorous (P) from the land to aquatic systems has polluted waters and threatened food production worldwide. Systematic trend analysis of P, a nonrenewable resource, has been challenging, primarily due to sparse and inconsistent historical data. Here, we leveraged intensive hydrometeorological data and the recent renaissance of deep learning approaches to fill data gaps and reconstruct temporal trends. We trained a multitask long short- term memory model for total P (TP) using da...
• Lamination- based organoid spatially resolved transcriptomics technique for primary lung and liver organoid characterization AI翻译
  作者：Ma, Shaohua; Wang, Wanlong; Zhou, Jiaqi; Liao, Shangfeng; Hai, Cheng; Hou, Yibo; Zhou, Zhichun; Wang, Zitian; Su, Yingshi; Zhu, Yu; Dai, Xiaoyong; Zhao, Yuan; Liao, Sha; Cai, Yongde; Xu, Xun
  作者单位：Tsinghua Shenzhen International Graduate School; Tsinghua University; Tsinghua Shenzhen International Graduate School; Tsinghua University; Beijing Genomics Institute (BGI)
  摘要：Spatial- transcriptomics technologies have demonstrated exceptional performance in characterizing brain and visceral organ tissues, as well as brain and retinal organoids. However, it has not yet been proven whether spatial transcriptomics can effectively characterize primary tissue- derived organoids, as the standardized tissue sectioning or slicing methods are not applicable for such organoids. Herein, we present a technique, lamination- based organoid spatially resolved transcriptomics (LOS...
• Inappropriate causal assumptions underlie Killingsworth, Kahneman, and Mellers' conclusions AI翻译
  作者：Rohrer, Julia M.; Wenz, Sebastian E.
  作者单位：Leipzig University; Leibniz Association; Leibniz Institut fur Sozialwissenschaften (GESIS)
• How neural systems transform synaptic plasticity into behavioral learning AI翻译
  作者：Lisberger, Stephen G.
  作者单位：Duke University
• How working from home reshapes cities AI翻译
  作者：Ramani, Arjun; Alcedo, Joel; Bloom, Nicholas
  作者单位：Massachusetts Institute of Technology (MIT); Stanford University
  摘要：In recent decades, economic activity has become increasingly concentrated in major global metropolises. Yet, the rise of working from home threatens this dominance of cities. Using multiple high- frequency datasets on spending, commuting, migration, and housing, we provide global evidence that remote work has dispersed economic activity away from city centers. We label this the Donut Effect, which is much larger and more persistent in cities with high levels of remote work. Using detailed hous...
• Three-dimensional isotropic imaging of live suspension cells enabled by droplet microvortices AI翻译
  作者：Cardenas-Benitez, Braulio; Hurtado, Richard; Luo, Xuhao; Lee, Abraham P.
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Fast, nondestructive three-dimensional (3D) imaging of live suspension cells remains challenging without substrate treatment or fixation, precluding scalable single-cell morphometry with minimal alterations. While optical sectioning techniques achieve 3D live cell imaging, lateral versus depth resolution differences further complicate analysis. We present a scalable microfluidic method capable of 3D fluorescent isotropic imaging of live, nonadherent cells suspended inside picoliter droplets wi...
• Cross- chiral exponential amplification of an RNA enzyme AI翻译
  作者：Cochrane, Wesley G.; Bare, Grant A. L.; Joyce, Gerald F.; Horning, David P.
  作者单位：Salk Institute
  摘要：An RNA ligase ribozyme that catalyzes the joining of RNA molecules of the opposite chiral handedness was optimized for the ability to synthesize its own enantiomer from two component fragments. The mirror- image D- and L- ligases operate in concert to provide a system for cross- chiral replication, whereby they catalyze each other's synthesis and undergo mutual amplification at constant temperature, with apparent exponential growth and a doubling time of about 1 h. Neither the D- nor the L- RN...
• Rapid shift in methane carbon isotopes suggests microbial emissions drove record high atmospheric methane growth in 2020-2022 AI翻译
  作者：Michel, Sylvia Englund; Lan, Xin; Miller, John; Tans, Pieter; Clark, J. Reid; Schaefer, Hinrich; Sperlich, Peter; Brailsford, Gordon; Morimoto, Shinji; Moossen, Heiko; Li, Jianghanyang
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; National Oceanic Atmospheric Admin (NOAA) - USA; National Institute of Water & Atmospheric Research (NIWA) - New Zealand; Tohoku University; Max Planck Society
  摘要：The growth rate of the atmospheric abundance of methane (CH4) reached a record high of 15.4 ppb yr-1 between 2020 and 2022, but the mechanisms driving the accelerated CH4 growth have so far been unclear. In this work, we use measurements of the 13C:12C Network and a box model to investigate potential drivers for the rapid CH4 growth. These measurements show that the record- high CH4 growth in 2020-2022 was accompanied by a sharp decline in S13CCH4, indicating that the increase in CH4 abundance...
• Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis ( vol 121 , e2407974121, 2024) AI翻译
  作者：Poon, Michael M.; Lorrain, Kym I.; Stebbins, Karin J.; Edu, Geraldine C.; Broadhead, Alexander R.; Lorenzana, Ariana J.; Roppe, Jeffrey R.; Baccei, Jill M.; Baccei, Christopher S.; Chen, Austin C.; Green, Ari J.; Lorrain, Daniel S.; Chan, Jonah R.
• The accomplices: Heparan sulfates and N- glycans foster SARS- CoV-2 spike:ACE2 receptor binding and virus priming AI翻译
  作者：Paiardi, Giulia; Ferraz, Matheus; Rusnati, Marco; Wade, Rebecca C.
  作者单位：Heidelberg Institute for Theoretical Studies; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Fundacao Oswaldo Cruz; Universidade Federal de Pernambuco; Ruprecht Karls University Heidelberg
  摘要：Although it is well established that the SARS-CoV-2 spike glycoprotein binds to the host cell ACE2 receptor to initiate infection, far less is known about the tissue tropism and host cell susceptibility to the virus. Differential expression across different cell types of heparan sulfate (HS) proteoglycans, with variably sulfated glycosaminoglycans (GAGs), and their synergistic interactions with host and viral N- glycans may contribute to tissue tropism and host cell susceptibility. Nevertheles...