6630期

最新文章

• Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides AI翻译
  作者：Bridges, Hannah R.; Blaza, James N.; Yin, Zhan; Chung, Injae; Pollak, Michael N.; Hirst, Judy
  作者单位：University of Cambridge; University of York - UK; University of York - UK; Lady Davis Institute; McGill University; McGill University
  摘要：The molecular mode of action of biguanides, including the drug metformin, which is widely used in the treatment of diabetes, is incompletely characterized. Here, we define the inhibitory drug-target interaction(s) of a model biguanide with mammalian respiratory complex I by combining cryo-electron microscopy and enzyme kinetics. We interpret these data to explain the selectivity of biguanide binding to different enzyme states. The primary inhibitory site is in an amphipathic region of the quin...
• ChatGPT is fun, but not an author AI翻译
  作者：Thorp, H. Holden
• A powerful 21st-century medium affords new opportunities for learning and creative thinkingBOOKS et al.INSIGHTS Science in the age of podcasts AI翻译
  作者：Gomez-Marin, Alex
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante (IN)
• Bird flu spread between mink is a 'warning bell' AI翻译
  作者：Kupferschmidt, Kai
• Collective super- and subradiant dynamics between distant optical quantum emitters AI翻译
  作者：Tiranov, Alexey; Angelopoulou, Vasiliki; Schrinski, Bjorn; van Diepen, Cornelis Jacobus; Sandberg, Oliver August Dall Alba; Wang, Ying; Midolo, Leonardo; Scholz, Sven; Wieck, Andreas Dirk; Ludwig, Arne; Sorensen, Anders Sondberg; Lodahl, Peter
  作者单位：University of Copenhagen; Ruhr University Bochum
  摘要：Photon emission is the hallmark of light-matter interaction and the foundation of photonic quantum science, enabling advanced sources for quantum communication and computing. Although single-emitter radiation can be tailored by the photonic environment, the introduction of multiple emitters extends this picture. A fundamental challenge, however, is that the radiative dipole-dipole coupling rapidly decays with spatial separation, typically within a fraction of the optical wavelength. We realize...
• AI helps find missed meteorites AI翻译
  作者：Brainard, Jeffrey
• Comment on Interspecific competition limits bird species' ranges in tropical mountains AI翻译
  作者：Xing, Dingliang; Zhang, Jian; He, Fangliang
  作者单位：East China Normal University; East China Normal University; University of Alberta
• Human geneticists apologize AI翻译
  作者：Brainard, Jeffrey
• Hidden costs of Europe's deforestation policy AI翻译
  作者：Fernandes, Geraldo W.; Oliveira, Hernani F. M.; Bergallo, Helena G.; Borges-Junior, Vitor N. T.; Colli, Guarino; Fernandes, Stephannie; Fonseca, Nathan C.; Garda, Adrian A.; Grelle, Carlos E. V.; Nunes, Andre V.; Perillo, Lucas N.; Rocha, Taina C.; Rodrigues, Domingos J.; da Silveira-Filho, Ricardo R.; Streit, Helena; Toma, Tiago S. P.; Viana, Pedro L.; Roque, Fabio O.
  作者单位：Universidade Federal de Minas Gerais; Universidade de Brasilia; Universidade do Estado do Rio de Janeiro; Universidade Federal do Rio de Janeiro; State University System of Florida; Florida International University; Universidade Federal Rural de Pernambuco (UFRPE); Universidade Federal do Rio Grande do Norte; Universidade Federal de Mato Grosso do Sul; Museu Paraense Emilio Goeldi; Universidade Federal de Mato Grosso; Universidade Federal do Rio Grande do Sul
• A vaccine sanctuary in the lymph node B cell follicles in the lymph node protect vaccines to enhance immune responses AI翻译
  作者：Kalia, Nurag; Hickman, Heather D.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)