作者：Lutz, Isaac D.; Wang, Shunzhi; Norn, Christoffer; Courbet, Alexis; Borst, Andrew J.; Zhao, Yan Ting; Dosey, Annie; Cao, Longxing; Xu, Jinwei; Leaf, Elizabeth M.; Treichel, Catherine; Litvicov, Patrisia; Li, Zhe; Goodson, Alexander D.; Rivera-Sanchez, Paula; Bratovianu, Ana -Maria; Baek, Minkyung; King, Neil P.; Ruohola-Baker, Hannele; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Westlake University; Seoul National University (SNU)
摘要：As a result of evolutionary selection, the subunits of naturally occurring protein assemblies often fit together with substantial shape complementarity to generate architectures optimal for function in a manner not achievable by current design approaches. We describe a top-down reinforcement learning- based design approach that solves this problem using Monte Carlo tree search to sample protein conformers in the context of an overall architecture and specified functional constraints. Cryo-elec...
作者：Machado, Ricardo B.; Aguiar, Ludmilla M. S.
作者单位：Universidade de Brasilia
作者：McCutcheon, Jeffrey R.; Mauter, Meagan S.
作者单位：University of Connecticut; Stanford University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
作者：Bild, Marius; Fadel, Matteo; Yang, Yu; von Lupke, Uwe; Martin, Phillip; Bruno, Alessandro; Chu, Yiwen
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：According to quantum mechanics, a physical system can be in any linear superposition of its possible states. Although the validity of this principle is routinely validated for microscopic systems, it is still unclear why we do not observe macroscopic objects to be in superpositions of states that can be distinguished by some classical property. Here we demonstrate the preparation of a mechanical resonator in Schrodinger cat states of motion, where the similar to 10(17) constituent atoms are in...
