作者：Rao, Srinivasa P. S.; Gould, Matthew K.; Noeske, Jonas; Saldivia, Manuel; Jumani, Rajiv S.; Ng, Pearly S.; Rene, Olivier; Chen, Yen-Liang; Kaiser, Marcel; Ritchie, Ryan; Francisco, Amanda Fortes; Johnson, Nila; Patra, Debjani; Cheung, Harry; Deniston, Colin; Schenk, Andreas D.; Cortopassi, Wilian A.; Schmidt, Remo S.; Wiedemar, Natalie; Thomas, Bryanna; Palkar, Rima; Ghafar, Nahdiyah A.; Manoharan, Vanessa; Luu, Catherine; Gable, Jonathan E.; Wan, Kah Fei; Myburgh, Elmarie; Mottram, Jeremy C.; Barnes, Whitney; Walker, John; Wartchow, Charles; Aziz, Natasha; Osborne, Colin; Wagner, Juergen; Sarko, Christopher; Kelly, John M.; Manjunatha, Ujjini H.; Maeser, Pascal; Jiricek, Jan; Lakshminarayana, Suresh B.; Barrett, Michael P.; Diagana, Thierry T.
作者单位：Novartis; Novartis USA; Novartis; Novartis Singapore; University of Glasgow; University of Basel; Swiss Tropical & Public Health Institute; University of Basel; University of London; London School of Hygiene & Tropical Medicine; Novartis; Novartis USA; Novartis; University of Hull; University of York - UK; University of York - UK
摘要：Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease and human African trypanosomiasis (HAT). Improved HAT treatments are available, but Chagas disease therapies rely on two nitroheterocycles, which suffer from lengthy drug regimens and safety concerns that cause frequent treatment discontinuation. We performed phenotypic screening against trypanosomes and identified a class of cyanotriazoles (CTs) with potent trypanocid...
作者：Zeng, Hu; Huang, Jiahao; Ren, Jingyi; Wang, Connie Kangni; Tang, Zefang; Zhou, Haowen; Zhou, Yiming; Shi, Hailing; Aditham, Abhishek; Sui, Xin; Chen, Hongyu; Lo, Jennifer A.; Wang, Xiao
作者单位：Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT)
摘要：The precise control of messenger RNA (mRNA) translation is a crucial step in posttranscriptional gene regulation of cellular physiology. However, it remains a challenge to systematically study mRNA translation at the transcriptomic scale with spatial and single-cell resolution. Here, we report the development of ribosome-bound mRNA mapping (RIBOmap), a highly multiplexed three-dimensional in situ profiling method to detect cellular translatome. RIBOmap profiling of 981 genes in HeLa cells reve...
作者：Shashidhara, L. S.; Joshi, Amitabh
作者单位：Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Department of Science & Technology (India); Jawaharlal Nehru Center for Advanced Scientific Research (JNCASR)
