作者：Zhang, Tao; Xu, Daichao; Trefts, Elijah; Lv, Mingming; Inuzuka, Hiroyuki; Song, Guobin; Liu, Min; Lu, Jianlin; Liu, Jianping; Chu, Chen; Wang, Min; Wang, Huibing; Meng, Huyan; Liu, Hui; Zhuang, Yuan; Xie, Xingxing; Dang, Fabin; Guan, Dongxian; Men, Yuqin; Jiang, Shuwen; Jiang, Cong; Dai, Xiaoming; Liu, Jing; Wang, Zhen; Yan, Peiqiang; Wang, Jingchao; Tu, Zhenbo; Babuta, Mrigya; Erickson, Emily; Hillis, Alissandra L.; Dibble, Christian C.; Asara, John M.; Szabo, Gyongy; Sicinski, Piotr; Miao, Ji; Lee, Yu-Ru; Pan, Lifeng; Shaw, Reuben J.; Yuan, Junying; Wei, Wenyi
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Harvard University; Harvard Medical School; Salk Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; St Jude Children's Research Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Huazhong University of Science & Technology; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Jinan University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Academia Sinica - Taiwan; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Organic Chemistry, CAS
摘要：Adenosine monophosphate-activated protein kinase (AMPK) activity is stimulated to promote metabolic adaptation upon energy stress. However, sustained metabolic stress may cause cell death. The mechanisms by which AMPK dictates cell death are not fully understood. We report that metabolic stress promoted receptor-interacting protein kinase 1 (RIPK1) activation mediated by TRAIL receptors, whereas AMPK inhibited RIPK1 by phosphorylation at Ser(415) to suppress energy stress-induced cell death. I...
作者：Dickson, J. L.; Palumbo, A. M.; Head, J. W.; Kerber, L.; Fassett, C. I.; Kreslavsky, M. A.
作者单位：California Institute of Technology; Brown University; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; National Aeronautics & Space Administration (NASA); University of California System; University of California Santa Cruz; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory
摘要：Gullies on Mars resemble water-carved channels on Earth, but they are mostly at elevations where liquid water is not expected under current climate conditions. It has been suggested that sublimation of carbon dioxide ice alone could have formed Martian gullies. We used a general circulation model to show that the highest-elevation Martian gullies coincide with the boundary of terrain that experienced pressures above the triple point of water when Mars' rotational axis tilt reached 35 degrees. ...
作者：Widen, Sonya A. A.; Bes, Israel Campo; Koreshova, Alevtina; Pliota, Pinelopi; Krogull, Daniel; Burga, Alejandro
作者单位：Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG)
摘要：INTRODUCTION When we think of DNA, we think of inheritance from parent to offspring. However, DNA can also be transmitted between individuals that are not related and even between individuals belonging to different species in a process known as horizontal gene transfer (HGT). Although best characterized in bacteria, a growing body of evidence indicates that HGT can also take place in a wide range of eukaryotes, including fungi, plants, and animals. However, one of the most fascinating aspects ...
