6655期

最新文章

• Finding my postdoc identity AI翻译
  作者：Elmassry, Moamen
  作者单位：Princeton University
• Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila AI翻译
  作者：Hanson, M. A.; Grollmus, L.; Lemaitre, B.
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); University of Exeter
  摘要：Antimicrobial peptides are host-encoded immune effectors that combat pathogens and shape the microbiome in plants and animals. However, little is known about how the host antimicrobial peptide repertoire is adapted to its microbiome. Here, we characterized the function and evolution of the Diptericin antimicrobial peptide family of Diptera. Using mutations affecting the two Diptericins (Dpt) of Drosophila melanogaster, we reveal the specific role of DptA for the pathogen Providencia rettgeri a...
• Genomic assessment of invasion dynamics of SARS-CoV-2 Omicron BA.1 AI翻译
  作者：Tsui, Joseph L. -H.; McCrone, John T.; Lambert, Ben; Bajaj, Sumali; Inward, Rhys P. D.; Bosetti, Paolo; Pena, Rosario Evans; Tegally, Houriiyah; Hill, Verity; Zarebski, Alexander E.; Peacock, Thomas P.; Liu, Luyang; Wu, Neo; Davis, Megan; Bogoch, Isaac I.; Khan, Kamran; Kall, Meaghan; Aziz, Nurin Iwani Binti Abdul; Colquhoun, Rachel; O'Toole, Aine; Jackson, Ben; Dasgupta, Abhishek; Wilkinson, Eduan; de Oliveira, Tulio; Connor, Thomas R.; Loman, Nicholas J.; Colizza, Vittoria; Fraser, Christophe; Volz, Erik; Ji, Xiang; Gutierrez, Bernardo; Chand, Meera; Dellicour, Simon; Cauchemez, Simon; Raghwani, Jayna; Suchard, Marc A.; Lemey, Philippe; Rambaut, Andrew; Pybus, Oliver G.; Kraemer, Moritz U. G.
  作者单位：University of Oxford; University of Edinburgh; University of Exeter; Centre National de la Recherche Scientifique (CNRS); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; University of Kwazulu Natal; Stellenbosch University; Yale University; Imperial College London; UK Health Security Agency (UKHSA); Alphabet Inc.; Google Incorporated; University of Toronto; University of Oxford; Cardiff University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Quadram Institute; University of Birmingham; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; University of Oxford; University of Oxford; Imperial College London; Tulane University; Universidad San Francisco de Quito; Universite Libre de Bruxelles; KU Leuven; University of London; University of London Royal Veterinary College; University of California System; University of California Los Angeles
  摘要：Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) now arise in the context of heterogeneous human connectivity and population immunity. Through a large-scale phylodynamic analysis of 115,622 Omicron BA.1 genomes, we identified >6,000 introductions of the antigenically distinct VOC into England and analyzed their local transmission and dispersal history. We find that six of the eight largest English Omicron lineages were already transmitting when Omicron wa...
• Reliable earthquake precursors? AI翻译
  作者：Burgmann, Roland
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
• Ultraflexible endovascular probes for brain recording through micrometer-scale vasculature AI翻译
  作者：Zhang, Anqi; Mandeville, Emiri T.; Xu, Lijun; Stary, Creed M.; Lo, Eng H.; Lieber, Charles M.
  作者单位：Stanford University; Stanford University; Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Stanford University
  摘要：Implantable neuroelectronic interfaces have enabled advances in both fundamental research and treatment of neurological diseases but traditional intracranial depth electrodes require invasive surgery to place and can disrupt neural networks during implantation. We developed an ultrasmall and flexible endovascular neural probe that can be implanted into sub-100-micrometer-scale blood vessels in the brains of rodents without damaging the brain or vasculature. In vivo electrophysiology recording ...
• Funding agencies say no to AI peer review AI翻译
  作者：Kaiser, Jocelyn
• Abandoned land: Overestimated potential AI翻译
  作者：Holl, Karen D.; Bukoski, Jacob J.; Curran, Sara R.; Potts, Matthew D.; Vincent, Jeffrey R.
  作者单位：University of California System; University of California Santa Cruz; Oregon State University; University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; Duke University
• Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF AI翻译
  作者：Patel, Calum; Andre-Joyaux, Emy; Leitch, Jamie A.; de Irujo-Labalde, Xabier Martinez; Ibba, Francesco; Struijs, Job; Ellwanger, Mathias A.; Paton, Robert; Browne, Duncan L.; Pupo, Gabriele; Aldridge, Simon; Hayward, Michael A.; Gouverneur, Veronique
  作者单位：University of Oxford; University of London; University College London; University of Oxford; Colorado State University System; Colorado State University Fort Collins
  摘要：All fluorochemicals-including elemental fluorine and nucleophilic, electrophilic, and radical fluorinating reagents-are prepared from hydrogen fluoride (HF). This highly toxic and corrosive gas is produced by the reaction of acid-grade fluorspar (>97% CaF2) with sulfuric acid under harsh conditions. The use of fluorspar to produce fluorochemicals via a process that bypasses HF is highly desirable but remains an unsolved problem because of the prohibitive insolubility of CaF2. Inspired by calci...
• Say Anarcha: A Young Woman, a Devious Surgeon, and the Harrowing Birth of Modern Women's Health AI翻译
  作者：Downs, Jim
  作者单位：Gettysburg College
• LOST IN TRANSLATION AI翻译
  作者：Ravindran, Sandeep