Ultraflexible endovascular probes for brain recording through micrometer-scale vasculature

• 成果类型: Article
• 署名作者: Zhang, Anqi; Mandeville, Emiri T.; Xu, Lijun; Stary, Creed M.; Lo, Eng H.; Lieber, Charles M.
• 署名单位: Stanford University; Stanford University; Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Stanford University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-12096
• DOI: 10.1126/science.adh3916
• 发表日期: 2023-07-21
• 页码: 306-312
• 关键词: induced epileptiform activity; cerebral-ischemia; electrode array; rat; MODEL; diameter; cortex; cells

摘要

Implantable neuroelectronic interfaces have enabled advances in both fundamental research and treatment of neurological diseases but traditional intracranial depth electrodes require invasive surgery to place and can disrupt neural networks during implantation. We developed an ultrasmall and flexible endovascular neural probe that can be implanted into sub-100-micrometer-scale blood vessels in the brains of rodents without damaging the brain or vasculature. In vivo electrophysiology recording of local field potentials and single-unit spikes have been selectively achieved in the cortex and olfactory bulb. Histology analysis of the tissue interface showed minimal immune response and long-term stability. This platform technology can be readily extended as both research tools and medical devices for the detection and intervention of neurological diseases.