6662期

最新文章

• Paris nouveau: insecticide fog AI翻译
  作者：[Anonymous]
• A type 2 immune circuit in the stomach controls mammalian adaptation to dietary chitin AI翻译
  作者：Kim, Do-Hyun; Wang, Yilin; Jung, Haerin; Field, Rachael L.; Zhang, Xinya; Liu, Ta-Chiang; Ma, Changqing; Fraser, James S.; Brestoff, Jonathan R.; Van Dyken, Steven J.
  作者单位：Washington University (WUSTL); University of California System; University of California San Francisco
  摘要：Dietary fiber improves metabolic health, but host-encoded mechanisms for digesting fibrous polysaccharides are unclear. In this work, we describe a mammalian adaptation to dietary chitin that is coordinated by gastric innate immune activation and acidic mammalian chitinase (AMCase). Chitin consumption causes gastric distension and cytokine production by stomach tuft cells and group 2 innate lymphoid cells (ILC2s) in mice, which drives the expansion of AMCase-expressing zymogenic chief cells th...
• Budget fight raises fears of spending cuts, research limits AI翻译
  作者：Brainard, Jeff; Kaiser, Jocelyn; Mervis, Jeffrey; Stokstad, Erik
• Cancer rises in younger adults AI翻译
  作者：[Anonymous]
• Distant galaxy had magnetic field AI翻译
  作者：[Anonymous]
• Implantable bioelectronic systems for early detection of kidney transplant rejection AI翻译
  作者：Madhvapathy, Surabhi R.; Wang, Jiao-Jing; Wang, Heling; Patel, Manish; Chang, Anthony; Zheng, Xin; Huang, Yonggang; Zhang, Zheng J.; Gallon, Lorenzo; Rogers, John A.
  作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Tsinghua University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Chicago; Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University; Northwestern University; Northwestern University
  摘要：Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur infrequently and are risky, and measuring biomarker levels in blood can lead to false-negative and -positive outcomes. We developed an implantable bioelectronic system capable of continuous, real-time, long-term monitoring of the local temperature and thermal conductivity of a kidney for detecting inflammatory processes associated with graft rejection, as demonstrated in rat models. The system detect...
• Kupffer cell-like syncytia replenish resident macrophage function in the fibrotic liver AI翻译
  作者：Peiseler, Moritz; David, Bruna Araujo; Zindel, Joel; Surewaard, Bas G. J.; Lee, Woo-Yong; Heymann, Felix; Nusse, Ysbrand; Castanheira, Fernanda V. S.; Shim, Raymond; Guillot, Adrien; Bruneau, Alix; Atif, Jawairia; Perciani, Catia; Ohland, Christina; Mukherjee, Priyanka Ganguli; Niehrs, Annika; Thuenauer, Roland; Altfeld, Marcus; Amrein, Mathias; Liu, Zhaoyuan; Gordon, Paul M. K.; McCoy, Kathy; Deniset, Justin; MacParland, Sonya; Ginhoux, Florent; Tacke, Frank; Kubes, Paul
  作者单位：University of Calgary; University of Calgary; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; University of Bern; University of Toronto; University Health Network Toronto; Toronto General Hospital; University of Calgary; Chinese Academy of Sciences; Shanghai Jiao Tong University; University of Calgary; University of Calgary; University of Calgary; University of Calgary; Libin Cardiovascular Institute Of Alberta; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; Universite Paris Saclay
  摘要：Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal cells to maintain their identity and serve as the body's central bacterial filter. Liver cirrhosis drastically alters vascular architecture, but how KCs adapt is unclear. We used a mouse model of liver fibrosis and human tissue to examine immune adaptation. Fibrosis forced KCs to lose contact with parenchymal cells, down-regulating KC identity, which rendered them incapable of clearing bacteria. Commensal...
• Editorial Expression of Concern AI翻译
  作者：Sills, Jennifer
• Against Technoableism: Rethinking Who Needs Improvement AI翻译
  作者：Berntsen, Leslie
• Hold big business to task on ecosystem restoration AI翻译
  作者：Lamont, Timothy A. C.; Barlow, Jos; Bebbington, Jan; Cuckston, Thomas; Djohani, Rili; Garrett, Rachael; Jones, Holly P.; Razak, Tries B.; Graham, Nicholas A. J.
  作者单位：Lancaster University; University of Birmingham; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Cambridge; University of Cambridge; Northern Illinois University; Northern Illinois University; National Research & Innovation Agency of Indonesia (BRIN)