Implantable bioelectronic systems for early detection of kidney transplant rejection

• 成果类型: Article
• 署名作者: Madhvapathy, Surabhi R.; Wang, Jiao-Jing; Wang, Heling; Patel, Manish; Chang, Anthony; Zheng, Xin; Huang, Yonggang; Zhang, Zheng J.; Gallon, Lorenzo; Rogers, John A.
• 署名单位: Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Tsinghua University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Chicago; Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University; Northwestern University; Northwestern University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11269
• DOI: 10.1126/science.adh7726
• 发表日期: 2023-09-08
• 页码: 1105-1112
• 关键词: temperature

摘要

Early-stage organ transplant rejection can be difficult to detect. Percutaneous biopsies occur infrequently and are risky, and measuring biomarker levels in blood can lead to false-negative and -positive outcomes. We developed an implantable bioelectronic system capable of continuous, real-time, long-term monitoring of the local temperature and thermal conductivity of a kidney for detecting inflammatory processes associated with graft rejection, as demonstrated in rat models. The system detects ultradian rhythms, disruption of the circadian cycle, and/or a rise in kidney temperature. These provide warning signs of acute kidney transplant rejection that precede changes in blood serum creatinine/urea nitrogen by 2 to 3 weeks and approximately 3 days for cases of discontinued and absent administration of immunosuppressive therapy, respectively.