作者：Luo, Yongrui; Li, Yuli; Wu, Jian; Xue, Xiao-Song; Hartwig, John F.; Shen, Qilong
作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Organic Chemistry, CAS; University of California System; University of California Berkeley
摘要：The step that cleaves the carbon-halogen bond in copper-catalyzed cross-coupling reactions remains ill defined because of the multiple redox manifolds available to copper and the instability of the highvalent copper product formed. We report the oxidative addition of a-haloacetonitrile to ionic and neutral copper(I) complexes to form previously elusive but here fully characterized copper(III) complexes. The stability of these complexes stems from the strong Cu-CF3 bond and the high barrier for...
作者：Lv, Xiangdong; Lu, Xuan; Cao, Jin; Luo, Qin; Ding, Yao; Peng, Fanglue; Pataer, Apar; Lu, Dong; Han, Dong; Malmberg, Eric; Chan, Doug W.; Wang, Xiaoran; Savage, Sara R.; Mao, Sufeng; Yu, Jingjing; Peng, Fei; Yan, Liang; Meng, Huan; Maneix, Laure; Han, Yumin; Chen, Yiwen; Yao, Wantong; Chang, Eric C.; Catic, Andre; Lin, Xia; Miles, George; Huang, Pengxiang; Sun, Zheng; Burt, Bryan; Wang, Huamin; Wang, Jin; Yao, Qizhi Cathy; Zhang, Bing; Roth, Jack A.; O'Malley, Bert W.; Ellis, Matthew J.; Rimawi, Mothaffar F.; Ying, Haoqiang; Chen, Xi
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; AstraZeneca
摘要：Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of multiple KRASi-resistance mechanisms. Inactivation of oncogenic KRAS down-regulated both the heat shock response and the inositol-requiring enzyme 1a (IRE1a) branch of the unfolded protein response, causing severe proteostasis disturbances. However, IRE1a was selectively reactivated in an...
