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作者：Zhang, Yanqiu; Wang, Hao; Guo, Jing; Cheng, Xiquan; Han, Gang; Lau, Cher Hon; Lin, Haiqing; Liu, Shaomin; Ma, Jun; Shao, Lu
作者单位：Harbin Institute of Technology; Harbin Institute of Technology; Harbin Institute of Technology; Nankai University; University of Edinburgh; State University of New York (SUNY) System; University at Buffalo, SUNY; Curtin University
摘要：Existing polyamide (PA) membrane synthesis protocols are underpinned by controlling diffusion-dominant liquid-phase reactions that yield subpar spatial architectures and ionization behavior. We report an ice-confined interfacial polymerization strategy to enable the effective kinetic control of the interfacial reaction and thermodynamic manipulation of the hexagonal polytype (I-h) ice phase containing monomers to rationally synthesize a three-dimensional quasilayered PA membrane for nanofiltra...
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作者：Zeidler, Vania G. Zuin
作者单位：Leuphana University Luneburg
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作者：Clery, Daniel; Kean, Sam
摘要：Researchers share award for developing quantum dots, which fluoresce in vivid colors determined by their size
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作者：Maroso, Mattia
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作者：Li, Yang Eric; Preissl, Sebastian; Miller, Michael; Johnson, Nicholas D.; Wang, Zihan; Jiao, Henry; Zhu, Chenxu; Wang, Zhaoning; Xie, Yang; Poirion, Olivier; Kern, Colin; Pinto-Duarte, Antonio; Tian, Wei; Siletti, Kimberly; Emerson, Nora; Osteen, Julia; Lucero, Jacinta; Lin, Lin; Yang, Qian; Zhu, Quan; Zemke, Nathan; Espinoza, Sarah; Yanny, Anna Marie; Nyhus, Julie; Dee, Nick; Casper, Tamara; Shapovalova, Nadiya; Hirschstein, Daniel; Hodge, Rebecca D.; Linnarsson, Sten; Bakken, Trygve; Levi, Boaz; Keene, C. Dirk; Shang, Jingbo; Lein, Ed; Wang, Allen; Behrens, M. Margarita; Ecker, Joseph R.; Ren, Bing
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Salk Institute; University of California System; University of California San Diego; Karolinska Institutet; Allen Institute for Brain Science; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Salk Institute; Washington University (WUSTL); University of Freiburg
摘要：Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the regulatory programs governing cell identity and function remain unclear. Using a single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq), we explored open chromatin landscapes across 1.1 million cells in 42 brain regions from three adults. Integrating this data unveiled 107 distinct cell types and their specific utilizati...
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作者：Pekar, J. E.
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作者：Vincent, Rosa L.; Gurbatri, Candice R.; Li, Fangda; Vardoshvili, Ana; Coker, Courtney; Im, Jongwon; Ballister, Edward R.; Rouanne, Mathieu; Savage, Thomas; de los Santos-Alexis, Kenia; Redenti, Andrew; Brockmann, Leonie; Komaranchath, Meghna; Arpaia, Nicholas; Danino, Tal
作者单位：Columbia University; Columbia University; Columbia University; Columbia University
摘要：A major challenge facing tumor-antigen targeting therapies such as chimeric antigen receptor (CAR)-T cells is the identification of suitable targets that are specifically and uniformly expressed on heterogeneous solid tumors. By contrast, certain species of bacteria selectively colonize immune-privileged tumor cores and can be engineered as antigen-independent platforms for therapeutic delivery. To bridge these approaches, we developed a platform of probiotic-guided CAR-T cells (ProCARs), in w...
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作者：Chan, Amy Y.; Ghosh, Atanu; Yarranton, Jonathan T.; Twilton, Jack; Jin, Jian; Arias-Rotondo, Daniela M.; Sakai, Holt A.; McCusker, James K.; MacMillan, David W. C.
作者单位：Princeton University; Michigan State University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; University of Chinese Academy of Sciences, CAS
摘要：Second- and third-row transition metal complexes are widely employed in photocatalysis, whereas earth-abundant first-row transition metals have found only limited use because of the prohibitively fast decay of their excited states. We report an unforeseen reactivity mode for productive photocatalysis that uses cobalt polypyridyl complexes as photocatalysts by exploiting Marcus inverted region behavior that couples increases in excited-state energies with increased excited-state lifetimes. Thes...
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作者：Gomez-Marin, Alex
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante (IN)
摘要：A foundational text that articulated the modern scientific method turns 400
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作者：Micali, Nicola; Ma, Shaojie; Li, Mingfeng; Kim, Suel-Kee; Mato-Blanco, Xoel; Sindhu, Suvimal Kumar; Arellano, Jon I.; Gao, Tianliuyun; Shibata, Mikihito; Gobeske, Kevin T.; Duque, Alvaro; Santpere, Gabriel; Sestan, Nenad; Rakic, Pasko
作者单位：Yale University; Huazhong University of Science & Technology; Pompeu Fabra University; Barcelona Biomedical Research Park; Hospital del Mar Research Institute; Hospital del Mar; Yale University; Yale University; Yale University
摘要：During early telencephalic development, intricate processes of regional patterning and neural stem cell (NSC) fate specification take place. However, our understanding of these processes in primates, including both conserved and species-specific features, remains limited. Here, we profiled 761,529 single-cell transcriptomes from multiple regions of the prenatal macaque telencephalon. We deciphered the molecular programs of the early organizing centers and their cross-talk with NSCs, revealing ...
