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作者：Couzin-Frankel, Jennifer
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作者：Li, Lijia; Lai, Fangnong; Hu, Xiaoyu; Liu, Bofeng; Lu, Xukun; Lin, Zili; Liu, Ling; Xiang, Yunlong; Frum, Tristan; Halbisen, Michael A.; Chen, Fengling; Fan, Qiang; Ralston, Amy; Xie, Wei
作者单位：Tsinghua University; Tsinghua University; Beijing University of Agriculture; Beijing University of Agriculture; Chongqing Medical University; Michigan State University; University of Michigan System; University of Michigan
摘要：Pioneer transcription factors (TFs), such as OCT4 and SOX2, play crucial roles in pluripotency regulation. However, the master TF-governed pluripotency regulatory circuitry was largely inferred from cultured cells. In this work, we investigated SOX2 binding from embryonic day 3.5 (E3.5) to E7.5 in the mouse. In E3.5 inner cell mass (ICM), SOX2 regulates the ICM-trophectoderm program but is dispensable for opening global enhancers. Instead, SOX2 occupies preaccessible enhancers in part opened b...
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作者：Mervis, Jeffrey
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作者：Migueles, Stephen A.; Nettere, Danielle M.; Gavil, Noah V.; Wang, Lawrence T.; Toulmin, Sushila A.; Kelly, Elizabeth P.; Ward, Addison J.; Lin, Siying; Thompson, Sarah A.; Peterson, Bennett A.; Abdeen, Cassidy S.; Sclafani, Carina R.; Pryal, Patrick F.; Leach, Benjamin G.; Ludwig, Amanda K.; Rogan, Daniel C.; Przygonska, Paulina A.; Cattani, Angela; Imamichi, Hiromi; Sachs, Abraham; Cafri, Gal; Huang, Ning-Na; Patamawenu, Andy; Liang, C. Jason; Hallahan, Claire W.; Kambach, Diane M.; Han, Edward X.; Coupet, Tiffany; Chen, Jonathan; Moir, Susan L.; Chun, Tae-Wook; Coates, Emily E.; Ledgerwood, Julie; Schmidt, Julien; Taillandier-Coindard, Marie; Michaux, Justine; Pak, HuiSong; Bassani-Sternberg, Michal; Frahm, Nicole; McElrath, M. Juliana; Connors, Mark
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Agilent Technologies; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Ludwig Institute for Cancer Research; University of Lausanne; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Fred Hutchinson Cancer Center; Duke University; University of Minnesota System; University of Minnesota Twin Cities; University of Massachusetts System; University of Massachusetts Worcester
摘要：Current HIV vaccines designed to stimulate CD8(+) T cells have failed to induce immunologic control upon infection. The functions of vaccine-induced HIV-specific CD8(+) T cells were investigated here in detail. Cytotoxic capacity was significantly lower than in HIV controllers and was not a consequence of low frequency or unaccumulated functional cytotoxic proteins. Low cytotoxic capacity was attributable to impaired degranulation in response to the low antigen levels present on HIV-infected t...
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作者：Golde, Todd E.; Levey, Allan I.
作者单位：Emory University
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作者：Huang, Xingyi; Li, Pengli
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University
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作者：Spragge, Frances; Bakkeren, Erik; Jahn, Martin T.; Araujo, Elizete B. N.; Pearson, Claire F.; Wang, Xuedan; Pankhurst, Louise; Cunrath, Olivier; Foster, Kevin R.
作者单位：University of Oxford; University of Oxford; University of Oxford; Kennedy Institute for Rheumatology; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
摘要：INTRODUCTION: The diverse bacterial species that colonize the human gut, which are collectively known as the gut microbiota, provide important health benefits. One of the key benefits is colonization resistance-the ability to restrict colonization of the gut by pathogens that can trigger disease. Multiple mechanisms have been found to influence the ability of the microbiota to provide colonization resistance, but these mechanisms are often context-specific and dependent on particular strains o...
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作者：Couzin-Frankel, Jennifer
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作者：Hering, Daniel; Schuerings, Christian; Wenskus, Franziska; Blackstock, Kirsty; Borja, Angel; Birk, Sebastian; Bullock, Craig; Carvalho, Laurence; Dagher-Kharrat, Magda Bou; Lakner, Sebastian; Lovric, Natasa; McGuinness, Shane; Nabuurs, Gert-Jan; Sanchez-Arcilla, Agustin; Settele, Josef; Pe'er, Guy
作者单位：University of Duisburg Essen; University of Duisburg Essen; James Hutton Institute; AZTI; University College Dublin; University College Dublin; Norwegian Institute for Water Research (NIVA); University of Rostock; University of Eastern Finland; Wageningen University & Research; Universitat Politecnica de Catalunya; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); University of the Philippines System; University of the Philippines Los Banos; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ)
摘要：The EU law would complement many others, but challenges loom In an attempt to halt and reverse biodiversity losses, the European Commission has proposed a new regulation, the Nature Restoration Law (NRL). It could become a cornerstone of Europe's ambitions to restore biodiversity and ecosystem services for decades to come (1) and demonstrate global leadership in addressing ongoing environmental crises. The draft of the law, which is a first globally, has been under political pressure from vari...
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作者：Ottoni, Felipe P.; Filgueira, Carlos Thiago S.; Lima, Brenda N.; Vieira, Lucas O.; Rangel-Pereira, Filipe; Oliveira, Rafael F.
作者单位：Universidade Federal do Maranhao; Universidade Federal do Maranhao; Universidade Federal do Maranhao; Universidade Federal do Maranhao; Universidade Federal do Rio de Janeiro
