作者：Vos, Marten H.
作者单位：Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm)
作者：Baudat, Frederic; de Massy, Bernard
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier
作者：Park, Simone L.; Christo, Susan N.; Wells, Alexandria C.; Gandolfo, Luke C.; Zaid, Ali; Alexandre, Yannick O.; Burn, Thomas N.; Schroeder, Jan; Collins, Nicholas; Han, Seong-Ji; Guillaume, Stephane M.; Evrard, Maximilien; Castellucci, Clara; Davies, Brooke; Osman, Maleika; Obers, Andreas; McDonald, Keely M.; Wang, Huimeng; Mueller, Scott N.; Kannourakis, George; Berzins, Stuart P.; Mielke, Lisa A.; Carbone, Francis R.; Kallies, Axel; Speed, Terence P.; Belkaid, Yasmine; Mackay, Laura K.
作者单位：University of Melbourne; Peter Doherty Institute; National Institutes of Health (NIH) - USA; University of Melbourne; Walter & Eliza Hall Institute; Federation University Australia; La Trobe University; Olivia Newton-John Cancer Research Institute; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of Pennsylvania
摘要：Skin-resident CD8(+) T cells include distinct interferon-gamma-producing [tissue-resident memory T type 1 (T(RM)1)] and interleukin-17 (IL-17)-producing (T(RM)17) subsets that differentially contribute to immune responses. However, whether these populations use common mechanisms to establish tissue residence is unknown. In this work, we show that T(RM)1 and T(RM)17 cells navigate divergent trajectories to acquire tissue residency in the skin. T(RM)1 cells depend on a T-bet-Hobit-IL-15 axis, wh...
作者：Harding, Christian D.; Vyazovskiy, Vladyslav V.
作者单位：University of California System; University of California San Diego; University of Oxford; University of Oxford; University of Oxford
作者：Creager, Angela N. H.
作者单位：Princeton University
