2023

最新文章

• Ethical research when abortion access is legally restricted AI翻译
  作者：Sugarman, Jeremy; Wenner, Danielle M.; Rid, Annette; Henry, Leslie Meltzer; Luna, Florencia; Klitzman, Robert; MacQueen, Kathleen M.; Rennie, Stuart; Singh, Jerome Amir; Gostin, Lawrence O.
  作者单位：Johns Hopkins University; Johns Hopkins University; Carnegie Mellon University; Carnegie Mellon University; National Institutes of Health (NIH) - USA; NIH Clinical Center (CC); University System of Maryland; University of Maryland Baltimore; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Centro Nacional Patagonico (CENPAT); Columbia University; Columbia University; FHI 360; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of Kwazulu Natal; University of Toronto; Georgetown University
  摘要：Risks and benefits of some clinical research may be altered The legal landscape surrounding abortion in the United States has shifted dramatically since the Supreme Court's June 2022 decision in Dobbs v. Jackson Women's Health Organization eliminated a nationwide right to abortion (1). In the year since, roughly half of US states have expanded abortion restrictions. Some consequences of heightened restrictions-including increased maternal morbidity and mortality and deepening socioeconomic and...
• Undersea mountains help slicken tectonic plates AI翻译
  作者：Voosen, Paul
• How AI can distort human beliefs AI翻译
  作者：Kidd, Celeste; Birhane, Abeba
  作者单位：University of California System; University of California Berkeley; Trinity College Dublin
  摘要：Models can convey biases and false information to users Individual humans form their beliefs by sampling a small subset of the available data in the world. Once those beliefs are formed with high certainty, they can become stubborn to revise. Fabrication and bias in generative artificial intelligence (AI) models are established phenomena that can occur as part of regular system use, in the absence of any malevolent forces seeking to push bias or disinformation. However, transmission of false i...
• Goddess images found at terrorist-damaged Iraq site AI翻译
  作者：[Anonymous]
• New farmlands threaten the North China leopard AI翻译
  作者：Dong, Xianghong; Ju, Tao
  作者单位：Guizhou University; Guangxi Academy of Sciences
• EU's draft AI law exempts research AI翻译
  作者：[Anonymous]
• What an Owl Knows: The New Science of the World's Most Enigmatic Birds AI翻译
  作者：Franklin, Alan B.
  作者单位：United States Department of Agriculture (USDA)
• Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria AI翻译
  作者：Naon, Deborah; Hernandez-Alvarez, Maria Isabel; Shinjo, Satoko; Wieczor, Milosz; Ivanova, Saska; Martins de Brito, Olga; Quintana, Albert; Hidalgo, Juan; Palacin, Manuel; Aparicio, Pilar; Castellanos, Juan; Lores, Luis; Sebastian, David; Fernandez-Veledo, Sonia; Vendrell, Joan; Joven, Jorge; Orozco, Modesto; Zorzano, Antonio; Scorrano, Luca
  作者单位：University of Padua; Veneto Institute Molecular Medicine; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; University of Barcelona; Fahrenheit Universities; Gdansk University of Technology; Autonomous University of Barcelona; Autonomous University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERER; Instituto de Salud Carlos III; Universitat Rovira i Virgili; Hospital Universitari De Tarragona Joan XXIII; Universitat Rovira i Virgili; Universitat Rovira i Virgili
  摘要：In eukaryotic cells, different organelles interact at membrane contact sites stabilized by tethers. Mitochondrial mitofusin 2 (MFN2) acts as a membrane tether that interacts with an unknown partner on the endoplasmic reticulum (ER). In this work, we identified the MFN2 splice variant ERMIT2 as the ER tethering partner of MFN2. Splicing of MFN2 produced ERMIT2 and ERMIN2, two ER-specific variants. ERMIN2 regulated ER morphology, whereas ERMIT2 localized at the ER-mitochondria interface and inte...
• INTO THE DARK AI翻译
  作者：Clery, Daniel
  摘要：A European space telescope sets off to discover the nature of dark energy-the biggest ingredient in the universe
• NAC controls cotranslational N-terminal methionine excision in eukaryotes AI翻译
  作者：Gamerdinger, Martin; Jia, Min; Schloemer, Renate; Rabl, Laurenz; Jaskolowski, Mateusz; Khakzar, Katrin M.; Ulusoy, Zeynel; Wallisch, Annalena; Jomaa, Ahmad; Hunaeus, Gundula; Scaiola, Alain; Diederichs, Kay; Ban, Nenad; Deuerling, Elke
  作者单位：University of Konstanz; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Konstanz
  摘要：N-terminal methionine excision from newly synthesized proteins, catalyzed cotranslationally by methionine aminopeptidases (METAPs), is an essential and universally conserved process that plays a key role in cell homeostasis and protein biogenesis. However, how METAPs interact with ribosomes and how their cleavage specificity is ensured is unknown. We discovered that in eukaryotes the nascent polypeptide-associated complex (NAC) controls ribosome binding of METAP1. NAC recruits METAP1 using a l...