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作者：Vandael, David; Jonas, Peter
作者单位：Institute of Science & Technology - Austria
摘要：The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of the hippocampus. Because of its comparatively large size, this synapse is accessible to direct presynaptic recording, allowing a rigorous investigation of the biophysical mechanisms of synaptic transmission and plasticity. Furthermore, because of its placement in the very center of the hippocampal memory circuit, this ...
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作者：Heidt, Amanda
摘要：The fish's genomes change so slowly that species separated since the dinosaurs can produce fertile hybrids today
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作者：Finucci, Brittany; Pacoureau, Nathan; Rigby, Cassandra L.; Matsushiba, Jay H.; Faure-Beaulieu, Nina; Sherman, C. Samantha; Vanderwright, Wade J.; Jabado, Rima W.; Charvet, Patricia; Mejia-Falla, Paola A.; Navia, Andres F.; Derrick, Danielle H.; Kyne, Peter M.; Pollom, Riley A.; Walls, Rachel H. L.; Herman, Katelyn B.; Kinattumkara, Bineesh; Cotton, Charles F.; Cuevas, Juan-Martin; Daley, Ross K.; Dharmadi; Ebert, David A.; Fernando, Daniel; Fernando, Stela M. C.; Francis, Malcolm P.; Huveneers, Charlie; Ishihara, Hajime; Kulka, David W.; Leslie, Robin W.; Neat, Francis; Orlov, Alexei M.; Rincon, Getulio; Sant, Glenn J.; Volvenko, Igor V.; Walker, Terence I.; Simpfendorfer, Colin A.; Dulvy, Nicholas K.
作者单位：National Institute of Water & Atmospheric Research (NIWA) - New Zealand; Virginia Polytechnic Institute & State University; James Cook University; Simon Fraser University; Nelson Mandela University; Universidade Federal do Ceara; Charles Darwin University; Zoological survey of India; State University of New York (SUNY) System; SUNY Cobleskill; National University of La Plata; Ministry of Marine Affairs and Fisheries; Moss Landing Marine Laboratories; National Research Foundation - South Africa; South African Institute for Aquatic Biodiversity; California Academy of Sciences; Flinders University South Australia; Fisheries & Oceans Canada; Rhodes University; University of Cape Town; Russian Academy of Sciences; Shirshov Institute of Oceanology; Russian Academy of Sciences; Saratov Scientific Center of the Russian Academy of Sciences; Severtsov Institute of Ecology & Evolution; Tomsk State University; University of Wollongong; University of Wollongong; Research lnstitute of Fisheries & Oceanography; University of Melbourne; Monash University; University of Tasmania
摘要：The deep ocean is the last natural biodiversity refuge from the reach of human activities. Deepwater sharks and rays are among the most sensitive marine vertebrates to overexploitation. One-third of threatened deepwater sharks are targeted, and half the species targeted for the international liver-oil trade are threatened with extinction. Steep population declines cannot be easily reversed owing to long generation lengths, low recovery potentials, and the near absence of management. Depth and ...
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作者：Li, Shuai; Lu, Lixin; Bhattacharyya, Swarnendu; Pearce, Carolyn; Li, Kai; Nienhuis, Emily T.; Doumy, Gilles; Schaller, R. D.; Moeller, S.; Lin, M. -F.; Dakovski, G.; Hoffman, D. J.; Garratt, D.; Larsen, Kirk A.; Koralek, J. D.; Hampton, C. Y.; Cesar, D.; Duris, Joseph; Zhang, Z.; Sudar, Nicholas; Cryan, James P.; Marinelli, A.; Li, Xiaosong; Inhester, Ludger; Santra, Robin; Young, Linda
作者单位：United States Department of Energy (DOE); Argonne National Laboratory; University of Washington; University of Washington Seattle; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); United States Department of Energy (DOE); Pacific Northwest National Laboratory; Washington State University; University of Chicago; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of Hamburg; University of Hamburg
摘要：Attosecond-pump/attosecond-probe experiments have long been sought as the most straightforward method for observing electron dynamics in real time. Although there has been much success with overlapped near-infrared femtosecond and extreme ultraviolet attosecond pulses combined with theory, true attosecond-pump/attosecond-probe experiments have been limited. We used a synchronized attosecond x-ray pulse pair from an x-ray free-electron laser to study the electronic response to valence ionizatio...
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作者：Mailho-Fontana, Pedro L.; Antoniazzi, Marta M.; Coelho, Guilherme R.; Pimenta, Daniel C.; Fernandes, Ligia P.; Kupfer, Alexander; Brodie Jr, Edmund D.; Jared, Carlos
作者单位：Instituto Butantan; Instituto Butantan; Universidade de Sao Paulo; University Hohenheim; Utah System of Higher Education; Utah State University
摘要：Among vertebrates, the yolk is commonly the only form of nutritional investment offered by the female to the embryo. Some species, however, have developed parental care behaviors associated with specialized food provisioning essential for offspring survival, such as the production of lipidic-rich parental milk in mammals. Here, we show that females of the egg-laying caecilian amphibian Siphonops annulatus provide similarly lipid-rich milk to altricial hatchlings during parental care. We observ...
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作者：Brainard, Jeffrey
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作者：Ochs, Fena; Green, Charlotte; Szczurek, Aleksander Tomasz; Pytowski, Lior; Kolesnikova, Sofia; Brown, Jill; Gerlich, Daniel Wolfram; Buckle, Veronica; Schermelleh, Lothar; Nasmyth, Kim Ashley
作者单位：University of Oxford; University of Oxford; Austrian Academy of Sciences; Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); Medical University of Vienna; Vienna Biocenter (VBC); University of Vienna; Medical University of Vienna; University of Oxford; University of Copenhagen
摘要：Eukaryotic genomes are organized by loop extrusion and sister chromatid cohesion, both mediated by the multimeric cohesin protein complex. Understanding how cohesin holds sister DNAs together, and how loss of cohesion causes age-related infertility in females, requires knowledge as to cohesin's stoichiometry in vivo. Using quantitative super-resolution imaging, we identified two discrete populations of chromatin-bound cohesin in postreplicative human cells. Whereas most complexes appear dimeri...
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作者：Brainard, Jeffrey
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作者：Triunfol, Marcia
摘要：A locally produced vaccine did well in a phase 3 clinical trial but won't be available until at least 2025
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作者：Drupp, M. A.; Haensel, M. C.; Fenichel, E. P.; Freeman, M.; Gollier, C.; Groom, B.; Heal, G. M.; Howard, P. H.; Millner, A.; Moore, F. C.; Nesje, F.; Quaas, M. F.; Smulders, S.; Sterner, T.; Traeger, C.; Venmans, F.
作者单位：University of Hamburg; Leipzig University; Potsdam Institut fur Klimafolgenforschung; Yale University; University of York - UK; Universite de Toulouse; Universite Toulouse 1 Capitole; Toulouse School of Economics; University of Exeter; University of London; London School Economics & Political Science; Columbia University; New York University; University of California System; University of California Davis; University of Copenhagen; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Tilburg University; University of Gothenburg; University of Oslo
摘要：Governments are catching up with economic theory and practice by increasingly integrating ecosystem service values into national planning processes, including benefitcost analyses of public policies. Such analyses require information not only about today's benefits from ecosystem services but also on how benefits change over time. We address a key limitation of existing policy guidance, which assumes that benefits from ecosystem services remain unchanged. We provide a practical rule that is gr...
