6709期

最新文章

• Australian lab aims to accelerate platypus breeding AI翻译
  作者：Brainard, Jeffrey
• What's killing lab yeast around the world? AI翻译
  作者：Herring, Molly
• A long section of serpentinized depleted mantle peridotite AI翻译
  作者：Lissenberg, C. Johan; Mccaig, Andrew M.; Lang, Susan Q.; Blum, Peter; Abe, Natsue; Brazelton, William J.; Coltat, Remi; Deans, Jeremy R.; Dickerson, Kristin L.; Godard, Marguerite; John, Barbara E.; Klein, Frieder; Kuehn, Rebecca; Lin, Kuan-Yu; Liu, Haiyang; Lopes, Ethan L.; Nozaka, Toshio; Parsons, Andrew J.; Pathak, Vamdev; Reagan, Mark K.; Robare, Jordyn A.; Savov, Ivan P.; Schwarzenbach, Esther M.; Sissmann, Olivier J.; Southam, Gordon; Wang, Fengping; Wheat, C. Geoffrey; Anderson, Lesley; Treadwell, Sarah
  作者单位：Cardiff University; University of Leeds; Woods Hole Oceanographic Institution; Texas A&M University System; Texas A&M University College Station; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Utah System of Higher Education; University of Utah; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Andaluz de Ciencias de la Tierra (IACT); University of Granada; University of Southern Mississippi; University of California System; University of California Santa Cruz; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; University of Wyoming; Woods Hole Oceanographic Institution; Martin Luther University Halle Wittenberg; University of Delaware; Chinese Academy of Sciences; Stanford University; Okayama University; University of Plymouth; Central University of Punjab; University of Iowa; Arizona State University; Arizona State University-Downtown Phoenix; University of Fribourg; IFP Energies Nouvelles; University of Queensland; Shanghai Jiao Tong University; University of Alaska System; University of Alaska Fairbanks; University of North Dakota Grand Forks
  摘要：The upper mantle is critical for our understanding of terrestrial magmatism, crust formation, and element cycling between Earth's solid interior, hydrosphere, atmosphere, and biosphere. Mantle composition and evolution have been primarily inferred by surface sampling and indirect methods. We recovered a long (1268-meter) section of serpentinized abyssal mantle peridotite interleaved with thin gabbroic intrusions. We find depleted compositions with notable variations in mantle mineralogy contro...
• Locking away depression AI翻译
  作者：Silva, Jose Cesar Hernandez; Proulx, Christophe D.
  作者单位：Laval University
• The β-d-manno-heptoses are immune agonists across kingdoms AI翻译
  作者：Tang, Yue; Tian, Xiaoying; Wang, Min; Cui, Yinglu; She, Yang; Shi, Zhaoxiang; Liu, Jiaqi; Mao, Huijin; Liu, Lilu; Li, Chao; Zhang, Yuwei; Li, Pengwei; Ma, Yue; Sun, Jinyuan; Du, Qing; Li, Jie; Wang, Jun; Li, De-feng; Wu, Bian; Shao, Feng; Chen, Yihua
  作者单位：Chinese Academy of Sciences; Institute of Microbiology, CAS; National Institute of Biological Sciences, Beijing; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Shenyang Pharmaceutical University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Microbiology, CAS; Beijing University of Chemical Technology; Tsinghua University
  摘要：Bacterial small molecule metabolites such as adenosine-diphosphate-d-glycero-beta-d-manno-heptose (ADP-heptose) and their derivatives act as effective innate immune agonists in mammals. We show that functional nucleotide-diphosphate-heptose biosynthetic enzymes (HBEs) are distributed widely in bacteria, archaea, eukaryotes, and viruses. We identified a conserved STTR5 motif as a hallmark of heptose nucleotidyltransferases that can synthesize not only ADP-heptose but also cytidine-diphosphate (...
• PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation AI翻译
  作者：Guo, Pengfei; Li, Bing; Dong, Wei; Zhou, Huabin; Wang, Li; Su, Ting; Carl, Christopher; Zheng, Yonggang; Hong, Yang; Deng, Hua; Pan, Duojia
  作者单位：Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
  摘要：Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular processes, many biomolecular condensates exist in a solid-like state, and their function and regulation are less understood. We show that the tumor suppressor Merlin, an upstream regulator of the Hippo pathway, localizes to both cell junctions and medial apical cortex in Drosophila epithelia, with the latter forming solid-like condensates that activate Hippo signaling. Merlin condensation required phosp...
• Design studies for clinical prediction AI翻译
  作者：Hilbert, Kevin; Weller, Peter; Ritter, Kerstin; Haynes, John-Dylan; Walter, Henrik; Lueken, Ulrike
  作者单位：Humboldt University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
• US Senate plan would boost NIH AI翻译
  作者：Brainard, Jeffrey
• Fire-against-fire HIV therapy passes key test in monkeys AI翻译
  作者：Cohen, Jon
• Ultrafast studies of elusive chemical reactions in the gas phase AI翻译
  作者：Dantus, Marcos
  作者单位：Michigan State University; Michigan State University; Michigan State University
  摘要：The chemical composition of the interstellar medium and planetary atmospheres is constantly in flux as atoms and molecules collide and interact with high-energy particles such as electrons, protons, and photons. These transformative processes ultimately lead to the coalescence of molecules and eventually the birth of stars. Our understanding of these chemical ecosystems relies on models that synthesize data from gas-phase experiments, providing insights into reaction cross sections. This Revie...