6709期

最新文章

• Engineered deletions of HIV replicate conditionally to reduce disease in nonhuman primates AI翻译
  作者：Pitchai, Fathima N. Nagoor; Tanner, Elizabeth J.; Khetan, Neha; Vasen, Gustavo; Levrel, Clara; Kumar, Arjun J.; Pandey, Shilpi; Ordonez, Tracy; Barnette, Philip; Spencer, David; Jung, Seung-Yong; Glazier, Joshua; Thompson, Cassandra; Harvey-Vera, Alicia; Son, Hye-In; Strathdee, Steffanie A.; Holguin, Leo; Urak, Ryan; Burnett, John; Burgess, William; Busman-Sahay, Kathleen; Estes, Jacob D.; Hessell, Ann; Fennessey, Christine M.; Keele, Brandon F.; Haigwood, Nancy L.; Weinberger, Leor S.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of Washington; University of Washington Seattle; Oregon Health & Science University; Oregon National Primate Research Center; Washington University (WUSTL); University of California System; University of California San Diego; City of Hope; Beckman Research Institute of City of Hope; University of Miami; Oregon Health & Science University; Aarhus University; Royal Melbourne Institute of Technology (RMIT); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Antiviral therapies with reduced frequencies of administration and high barriers to resistance remain a major goal. For HIV, theories have proposed that viral-deletion variants, which conditionally replicate with a basic reproductive ratio [R0] > 1 (termed therapeutic interfering particles or TIPs), could parasitize wild-type virus to constitute single-administration, escape-resistant antiviral therapies. We report the engineering of a TIP that, in rhesus macaques, reduces viremia of a highly ...
• The lasting effects of famine AI翻译
  作者：Klimek, Peter; Thurner, Stefan
  作者单位：Medical University of Vienna; Karolinska Institutet; The Santa Fe Institute
  摘要：Early exposure to food scarcity in Ukraine increases diabetes risk in later life Although the short-term effects of famines on health have been well documented, the long-term effects have been more difficult to study owing to the decades that typically elapse between famine exposure and the development of disease. Previous studies have used famines in the Netherlands (1), Austria (2), China (3), and Nigeria (4) as natural experiments and linked malnutrition during pregnancy with increased risk...
• Regenerative cell therapy with 3D bioprinting AI翻译
  作者：Zhang, Yu Shrike; Dolatshahi-Pirouz, Alireza; Orive, Gorka
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Technical University of Denmark; University of Basque Country; Bioaraba Health Research Institute
• High-temperature quantum valley Hall effect with quantized resistance and a topological switch AI翻译
  作者：Huang, Ke; Fu, Hailong; Watanabe, Kenji; Taniguchi, Takashi; Zhu, Jun
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; National Institute for Materials Science; National Institute for Materials Science; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Zhejiang University
  摘要：Edge states of a topological insulator can be used to explore fundamental science emerging at the interface of low dimensionality and topology. Achieving a robust conductance quantization, however, has proven challenging for helical edge states. In this work, we show wide resistance plateaus in kink states-a manifestation of the quantum valley Hall effect in Bernal bilayer graphene-quantized to the predicted value at zero magnetic field. The plateau resistance has a very weak temperature depen...
• Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins AI翻译
  作者：Fallon, Timothy R.; Shende, Vikram V.; Wierzbicki, Igor H.; Pendleton, Amanda L.; Watervoot, Nathan F.; Auber, Robert P.; Gonzalez, David J.; Wisecaver, Jennifer H.; Moore, Bradley S.
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California San Diego; University of California System; University of California San Diego; Purdue University System; Purdue University; Purdue University System; Purdue University; University of California System; University of California San Diego
  摘要：Prymnesium parvum are harmful haptophyte algae that cause massive environmental fish kills. Their polyketide polyether toxins, the prymnesins, are among the largest nonpolymeric compounds in nature and have biosynthetic origins that have remained enigmatic for more than 40 years. In this work, we report the PKZILLAs, massive P. parvum polyketide synthase (PKS) genes that have evaded previous detection. PKZILLA-1 and -2 encode giant protein products of 4.7 and 3.2 megadaltons that have 140 and ...
• In sweeping geological theory, mantle waves lift up plateaus AI翻译
  作者：Richter, Hannah
• Regulation of the hematopoietic stem cell pool by C-Kit-associated trogocytosis AI翻译
  作者：Gao, Xin; Carpenter, Randall S.; Boulais, Philip E.; Zhang, Dachuan; Marlein, Christopher R.; Li, Huihui; Smith, Matthew; Chung, David J.; Maryanovich, Maria; Will, Britta; Steidl, Ulrich; Frenette, Paul S.
  作者单位：Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; University of Wisconsin System; University of Wisconsin Madison; Shanghai Jiao Tong University; Memorial Sloan Kettering Cancer Center; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University
  摘要：Hematopoietic stem cells (HSCs) are routinely mobilized from the bone marrow (BM) to the blood circulation for clinical transplantation. However, the precise mechanisms by which individual stem cells exit the marrow are not understood. This study identified cell-extrinsic and molecular determinants of a mobilizable pool of blood-forming stem cells. We found that a subset of HSCs displays macrophage-associated markers on their cell surface. Although fully functional, these HSCs are selectively ...
• Biogeographic climate sensitivity controls Earth system response to large igneous province carbon degassing AI翻译
  作者：Rogger, Julian; Judd, Emily J.; Mills, Benjamin J. W.; Godderis, Yves; Gerya, Taras V.; Pellissier, Loic
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Arizona; University of Leeds; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research
  摘要：Periods of large igneous province (LIP) magmatism have shaped Earth's biological and climatic history, causing major climatic shifts and biological reorganizations. The vegetation response to LIP-induced perturbations may affect the efficiency of the carbon-climate regulation system and the post-LIP climate evolution. Using an eco-evolutionary vegetation model, we demonstrate here that the vegetation's climate adaptation capacity, through biological evolution and geographic dispersal, is a maj...
• Cambodia breaks ground on controversial canal AI翻译
  作者：Brainard, Jeffrey
• A NEW FORCE EMERGES IN GENOMICS AI翻译
  作者：Cohen, Jon; Tsanni, Abdullahi