6710期

最新文章

• Predicting satellite swarms AI翻译
  作者：Brainard, Jeffrey
• Compensatory mutations potentiate constructive neutral evolution by gene duplication AI翻译
  作者：Despres, Philippe C.; Dube, Alexandre K.; Picard, Marie-Eve; Grenier, Jordan; Shi, Rong; Landry, Christian R.
  作者单位：Laval University; Laval University; Laval University; Laval University; Laval University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Guelph
  摘要：The functions of proteins generally depend on their assembly into complexes. During evolution, some complexes have transitioned from homomers encoded by a single gene to heteromers encoded by duplicate genes. This transition could occur without adaptive evolution through intermolecular compensatory mutations. Here, we experimentally duplicated and evolved a homodimeric enzyme to determine whether and how this could happen. We identified hundreds of deleterious mutations that inactivate individ...
• Drivers of epidemic dynamics in real time from daily digital COVID-19 measurements AI翻译
  作者：Kendall, Michelle; Ferretti, Luca; Wymant, Chris; Tsallis, Daphne; Petrie, James; Di Francia, Andrea; Di Lauro, Francesco; Abeler-Dorner, Lucie; Manley, Harrison; Panovska-Griffiths, Jasmina; Ledda, Alice; Didelot, Xavier; Fraser, Christophe
  作者单位：University of Warwick; University of Oxford; University of Oxford; UK Health Security Agency (UKHSA); University of Warwick
  摘要：Understanding the drivers of respiratory pathogen spread is challenging, particularly in a timely manner during an ongoing epidemic. In this work, we present insights that we obtained using daily data from the National Health Service COVID-19 app for England and Wales and that we shared with health authorities in almost real time. Our indicator of the reproduction number R(t) was available days earlier than other estimates, with an innovative capability to decompose R(t) into contact rates and...
• Divergent recruitment of developmentally defined neuronal ensembles supports memory dynamics AI翻译
  作者：Kveim, Vilde A.; Salm, Laurenz; Ulmer, Talia; Lahr, Maria; Kandler, Steffen; Imhof, Fabia; Donato, Flavio
  作者单位：University of Basel
  摘要：Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of memory-encoding neuronal ensembles influence the evolution of a memory over time. By targeting developmentally distinct subpopulations of principal neurons, we discovered that memory encoding resulted in the concurrent establishment of multiple memory traces in the mouse hippocampus. Two ...
• Multistage maturation optimizes vision(vol 384,pg 848, 2024) AI翻译
  作者：Mamassian, P.
• A BARRage of firing while asleep AI翻译
  作者：Mou, Xiang; Ji, Daoyun
  作者单位：Baylor College of Medicine; Baylor College of Medicine
  摘要：Memory reactivation requires counterbalancing to consolidate memories
• Biospecimen research and the law AI翻译
  作者：Dye, Timothy D.; Menikoff, Jerry A.
  作者单位：University of Rochester; University of Rochester; University of Rochester; National University of Singapore
  摘要：In the well-known case of Henrietta Lacks, cells from her tumor were taken without consent and used more than 70 years ago to create the first immortal human cell line (HeLa cells). That event led to many scientific breakthroughs and to the debate about the ethics of consent and requirements for compensation. May 2024 saw two decisions by US federal courts-one related to Lacks-that could narrow the scope of research allowed on tissues obtained without consent and on nonidentified tissues, with...
• Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity AI翻译
  作者：Matsumoto, Naoyuki; Barson, Daniel; Liang, Liang; Crair, Michael C.
  作者单位：Yale University; Yale University; Yale University; Yale University
  摘要：Spontaneous activity refines neural connectivity prior to the onset of sensory experience, but it remains unclear how such activity instructs axonal connectivity with subcellular precision. We simultaneously measured spontaneous retinal waves and the activity of individual retinocollicular axons and tracked morphological changes in axonal arbors across hours in vivo in neonatal mice. We demonstrate that the correlation of an axon branch's activity with neighboring axons or postsynaptic neurons...
• Antarctic vegetation map could aid conservation AI翻译
  作者：Brainard, Jeffrey
• Equity weighting increases the social cost of carbon AI翻译
  作者：Prest, Brian C.; Rennels, Lisa; Errickson, Frank; Anthoff, David
  作者单位：Resources for the Future; University of California System; University of California Berkeley; Princeton University
  摘要：New government guidelines could transform benefit-cost analysis of US climate policy