6712期

最新文章

• AAAS Pacific Division says farewell after a century AI翻译
  作者：Korte, Andrea
  摘要：102nd annual meeting was the last as AAAS shifts to community engagement focus 102nd annual meeting was the last as AAAS shifts to community engagement focus
• Morphine-responsive neurons that regulate mechanical antinociception AI翻译
  作者：Fatt, Michael P.; Zhang, Ming-Dong; Kupari, Jussi; Altinkok, Muge; Yang, Yunting; Hu, Yizhou; Svenningsson, Per; Ernfors, Patrik
  作者单位：Karolinska Institutet; Karolinska Institutet
  摘要：Opioids are widely used, effective analgesics to manage severe acute and chronic pain, although they have recently come under scrutiny because of epidemic levels of abuse. While these compounds act on numerous central and peripheral pain pathways, the neuroanatomical substrate for opioid analgesia is not fully understood. By means of single-cell transcriptomics and manipulation of morphine-responsive neurons, we have identified an ensemble of neurons in the rostral ventromedial medulla (RVM) t...
• Threat Multiplier: Climate, Military Leadership, and the Fight for Global Security AI翻译
  作者：Ali, Saleem H.
  作者单位：University of Delaware
  摘要：A policy pioneer's memoir shows how climate science penetrated the defense sector
• In situ observations of large-amplitude Alfvén waves heating and accelerating the solar wind AI翻译
  作者：Rivera, Yeimy J.; Badman, Samuel T.; Stevens, Michael L.; Verniero, Jaye L.; Stawarz, Julia E.; Shi, Chen; Raines, Jim M.; Paulson, Kristoff W.; Owen, Christopher J.; Niembro, Tatiana; Louarn, Philippe; Livi, Stefano A.; Lepri, Susan T.; Kasper, Justin C.; Horbury, Timothy S.; Halekas, Jasper S.; Dewey, Ryan M.; De Marco, Rossana; Bale, Stuart D.
  作者单位：Smithsonian Institution; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Northumbria University; University of California System; University of California Los Angeles; University of Michigan System; University of Michigan; University of London; University College London; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Southwest Research Institute; Imperial College London; University of California System; University of California Berkeley
  摘要：After leaving the Sun's corona, the solar wind continues to accelerate and cools, but more slowly than expected for a freely expanding adiabatic gas. Alfv & eacute;n waves are perturbations of the interplanetary magnetic field that transport energy. We use in situ measurements from the Parker Solar Probe and Solar Orbiter spacecraft to investigate a stream of solar wind as it traverses the inner heliosphere. The observations show heating and acceleration of the plasma between the outer edge of...
• A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements AI翻译
  作者：Martin, Sara; Scorzoni, Simone; Cordone, Sara; Mazzagatti, Alice; Beznoussenko, Galina V.; Gunn, Amanda L.; Di Bona, Melody; Eliezer, Yonatan; Leor, Gil; Ben-Yishay, Tal; Loffreda, Alessia; Cancila, Valeria; Rainone, Maria Chiara; Ippolito, Marica Rosaria; Martis, Valentino; Bedin, Fabio; Garre, Massimiliano; Vaites, Laura Pontano; Vasapolli, Paolo; Polo, Simona; Parazzoli, Dario; Tripodo, Claudio; Mironov, Alexander A.; Cuomo, Alessandro; Ben-David, Uri; Bakhoum, Samuel F.; Hatch, Emily M.; Ly, Peter; Santaguida, Stefano
  作者单位：IRCCS European Institute of Oncology (IEO); University of Texas System; University of Texas Southwestern Medical Center; IFOM - FIRC Institute of Molecular Oncology; Fred Hutchinson Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Tel Aviv University; Tel Aviv University; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Palermo; Harvard University; Harvard Medical School; University of Milan; Royal College of Surgeons - Ireland
  摘要：Chromosomal instability (CIN) generates micronuclei-aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are characterized by persistent DNA damage and catastrophic nuclear envelope collapse, which exposes DNA to the cytoplasm. We found that the autophagic receptor p62/SQSTM1 modulates micronuclear stability, influencing chromosome fragmentation and rearrangements. Mechanistically, proximity of micronuclei to mitoch...
• Team wrings H2O from lunar soil AI翻译
  作者：Brainard, Jeffrey
• Adrenaline as soul food AI翻译
  作者：Childress, Luke
  作者单位：University of Arkansas System; University of Arkansas Medical Sciences
• Climate Capitalism: Winning the Race to Zero Emissions and Solving the Crisis of Our Age AI翻译
  作者：Ali, Saleem H.
  作者单位：University of Delaware
• Element cycling with micro(nano)plastics AI翻译
  作者：Huang, Wei; Xia, Xinghui
  作者单位：Beijing Normal University
  摘要：Plastics in the environment can alter a wide range of biogeochemical cycles Plastic pollution of oceans, terrestrial ecosystems, fresh water, and the atmosphere is pervasive. However, understanding of the interaction between plastics that contaminate the environment and Earth's biogeochemical cycles of elements (carbon, nitrogen, phosphorus, sulfur) is only beginning to emerge. Microplastics (plastic particles <5 mm) and nanoplastics (<1 mu m) are particularly widespread. They originate from t...
• Synthetic biology startups face a 'reckoning' AI翻译
  作者：Service, Robert F.
  摘要：Three big firms falter, but startups find niches in pharma and other small-volume markets