6712期

最新文章

• Underappreciated government research support in patents AI翻译
  作者：Kwon, Seokbeom
  作者单位：Sungkyunkwan University (SKKU)
  摘要：Although federally funded research plays a crucial role in driving innovation ( 1, 2 ), its contribution is underestimated when the US government's research support is not properly acknowledged in patents from an evaluation perspective. Moreover, because the US government is entitled to exercise patents arising from its research support for public safety or public health when the US government's involvement in patents is properly acknowledged, failure to document its research support in patent...
• UK approves Alzheimer's drug AI翻译
  作者：Brainard, Jeffrey
• PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress AI翻译
  作者：Brar, Karinder K.; Hughes, Daniel T.; Morris, Jordan L.; Subramanian, Kelly; Krishna, Shivaani; Gao, Fei; Rieder, Lara-Sophie; Uhrig, Sebastian; Freeman, Joshua; Smith, Heather L.; Jukes-Jones, Rebekkah; Avezov, Edward; Nunnari, Jodi; Prudent, Julien; Butcher, Adrian J.; Mallucci, Giovanna R.
  作者单位：University of Cambridge; University of Cambridge; University of Cambridge; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of California System; University of California Davis
  摘要：Endoplasmic reticulum (ER) stress induces the repression of protein synthesis throughout the cell. Attempts to understand how localized stress leads to widespread repression have been limited by difficulties in resolving translation rates at the subcellular level. Here, using live-cell imaging of reporter mRNA translation, we unexpectedly found that during ER stress, active translation at mitochondria was significantly protected. The mitochondrial protein ATPase family AAA domain-containing pr...
• A sustainability science prize-reserved, so far, for men AI翻译
  作者：Wadman, Meredith
  摘要：Does new Frontiers Planet Prize-with its millions-perpetuate old inequities? Does new Frontiers Planet Prize-with its millions-perpetuate old inequities?
• Aggregate-selective removal of pathological tau by clustering-activated degraders AI翻译
  作者：Benn, Jonathan; Cheng, Shi; Keeling, Sophie; Smith, Annabel E.; Vaysburd, Marina J.; Boken, Dorothea; Miller, Lauren V. C.; Katsinelos, Taxiarchis; Franco, Catarina; Dupre, Elian; Danis, Clement; Landrieu, Isabelle; Buee, Luc; Klenerman, David; James, Leo C.; McEwan, William A.
  作者单位：University of Cambridge; MRC Laboratory Molecular Biology; Centre National de la Recherche Scientifique (CNRS); Universite de Lille; CHU Lille; Pasteur Network; Institut Pasteur Lille; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Lille; CHU Lille; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Selective degradation of pathological protein aggregates while sparing monomeric forms is of major therapeutic interest. The E3 ligase tripartite motif-containing protein 21 (TRIM21) degrades antibody-bound proteins in an assembly state-specific manner due to the requirement of TRIM21 RING domain clustering for activation, yet effective targeting of intracellular assemblies remains challenging. Here, we fused the RING domain of TRIM21 to a target-specific nanobody to create intracellularly exp...
• Micronuclear collapse from oxidative damage AI翻译
  作者：Di Bona, Melody; Chen, Yanyang; Agustinus, Albert S.; Mazzagatti, Alice; Duran, Mercedes A.; Deyell, Matthew; Bronder, Daniel; Hickling, James; Hong, Christy; Scipioni, Lorenzo; Tedeschi, Giulia; Martin, Sara; Li, Jun; Ruzgaite, Ausrine; Riaz, Nadeem; Shah, Parin; D'Souza, Edridge K.; Brodtman, D. Zack; Sidoli, Simone; Diplas, Bill; Jalan, Manisha; Lee, Nancy Y.; Ordureau, Alban; Izar, Benjamin; Laughney, Ashley M.; Powell, Simon; Gratton, Enrico; Santaguida, Stefano; Maciejowski, John; Ly, Peter; Jeitner, Thomas M.; Bakhoum, Samuel F.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; University of Texas System; University of Texas Southwestern Medical Center; Cornell University; Weill Cornell Medicine; University of California System; University of California Irvine; University of California System; University of California Irvine; IRCCS European Institute of Oncology (IEO); Columbia University; Yeshiva University; Memorial Sloan Kettering Cancer Center; University of Milan; Cornell University; Weill Cornell Medicine
  摘要：Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation, yet mechanisms safeguarding micronuclear integrity are poorly understood. In this study, we found that mitochondria-derived reactive oxygen species (ROS) disrupt micronuclei by promoting a noncanonical function of charg...
• Why Animals Talk:The New Science of Animal Communication AI翻译
  作者：Patricelli, Gail
  作者单位：University of California System; University of California Davis
  摘要：A zoologist probes the origins of complex communication in the animal world
• Safeguard the endemic species of Honduras AI翻译
  作者：Turcios-Casco, Manfredo Alejandro; Lopez, Celeste Maria
  作者单位：Universidade Estadual de Santa Cruz
• The microbial zoo in our food AI翻译
  作者：Brainard, Jeffrey
• Dark matter slips the net again AI翻译
  作者：Brainard, Jeffrey