6717期

最新文章

• Cancer immunotherapy by γδ T cells AI翻译
  作者：Hayday, Adrian; Dechanet-Merville, Julie; Rossjohn, Jamie; Silva-Santos, Bruno
  作者单位：Francis Crick Institute; University of London; King's College London; Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; Monash University; Monash University; Cardiff University; Universidade de Lisboa
  摘要：The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and immunological memory can jointly eradicate cancers and inoperable metastases and de facto vaccinate against recurrence. For some patients with hitherto incurable diseases, including metastatic melanoma, this promise is being realized by game-changing immunotherapies based on alpha beta T cells. Tod...
• Creation of de novo cryptic splicing for ALS and FTD precision medicine AI翻译
  作者：Wilkins, Oscar G.; Chien, Max Z. Y. J.; Wlaschin, Josette J.; Barattucci, Simone; Harley, Peter; Mattedi, Francesca; Mehta, Puja R.; Pisliakova, Maria; Ryadnov, Eugeni; Keuss, Matthew J.; Thompson, David; Digby, Holly; Knez, Lea; Simkin, Rebecca L.; Diaz, Juan Antinao; Zanovello, Matteo; Brown, Anna-Leigh; Darbey, Annalucia; Karda, Rajvinder; Fisher, Elizabeth M. C.; Cunningham, Thomas J.; Le Pichon, Claire E.; Ule, Jernej; Fratta, Pietro
  作者单位：University of London; University College London; Francis Crick Institute; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); Johns Hopkins University; MRC Harwell; University of London; King's College London; University of London; University College London; University of London; University College London; University of London; University College London
  摘要：Loss of function of the RNA-binding protein TDP-43 (TDP-LOF) is a hallmark of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here we describe TDP-REG, which exploits the specificity of cryptic splicing induced by TDP-LOF to drive protein expression when and where the disease process occurs. The SpliceNouveau algorithm combines deep learning with rational design to generate customizable cryptic splicing events within protein-coding sequences. We demonstrate that expr...
• FDA OKs schizophrenia drug AI翻译
  作者：Brainard, Jeffrey
• A bird's-eye view of avian extinctions AI翻译
  作者：Kemp, Melissa E.
  作者单位：University of Texas System; University of Texas Austin
• Photocatalytic furan-to-pyrrole conversion AI翻译
  作者：Kim, Donghyeon; You, Jaehyun; Lee, Da Hye; Hong, Hojin; Kim, Dongwook; Park, Yoonsu
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Institute for Basic Science - Korea (IBS)
  摘要：The identity of a heteroatom within an aromatic ring influences the chemical properties of that heterocyclic compound. Systematically evaluating the effect of a single atom, however, poses synthetic challenges, primarily as a result of thermodynamic mismatches in atomic exchange processes. We present a photocatalytic strategy that swaps an oxygen atom of furan with a nitrogen group, directly converting the furan into a pyrrole analog in a single intermolecular reaction. High compatibility was ...
• Tricking phages with a reverse move AI翻译
  作者：Osterman, Ilya; Sorek, Rotem
  作者单位：Weizmann Institute of Science
• A cautious approach to subsidies for environmental sustainability AI翻译
  作者：Segerson, Kathleen; Polasky, Stephen; Scheffer, Marten; Sumaila, U. Rashid; Cardenas, Juan Camilo; Nyborg, Karine; Fenichel, Eli P.; Anderies, John M.; Barrett, Scott; Bennett, Elena M.; Carpenter, Stephen R.; Crona, Beatrice; Daily, Gretchen; de Zeeuw, Aart; Fischer, Joern; Folke, Carl; Kautsky, Nils; Kremen, Claire; Levin, Simon A.; Lindahl, Therese; Pinsky, Malin L.; Tavoni, Alessandro; Walker, Brian; Weber, Elke U.
• Single-atom editing with light A new reaction swaps an oxygen for a nitrogen in structurally complex molecules AI翻译
  作者：Plachinski, Ellie F.; Yoon, Tehshik P.
  作者单位：University of Wisconsin System; University of Wisconsin Madison
• NIH finds research misconduct AI翻译
  作者：Brainard, Jeffrey
• A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection AI翻译
  作者：Alameh, Mohamad-Gabriel; Semon, Alexa; Bayard, Nile U.; Pan, Yi-Gen; Dwivedi, Garima; Knox, James; Glover, Rochelle C.; Rangel, Paula C.; Tanes, Ceylan; Bittinger, Kyle; She, Qianxuan; Hu, Haitao; Bonam, Srinivasa Reddy; Maslanka, Jeffrey R.; Planet, Paul J.; Moustafa, Ahmed M.; Davis, Benjamin; Chevrier, Anik; Beattie, Mitchell; Ni, Houping; Blizard, Gabrielle; Furth, Emma E.; Mach, Robert H.; Lavertu, Marc; Sellmyer, Mark A.; Tam, Ying; Abt, Michael C.; Weissman, Drew; Zackular, Joseph P.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Texas System; University of Texas Medical Branch Galveston; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; American Museum of Natural History (AMNH); Universite de Montreal; Polytechnique Montreal; University of Pennsylvania; University of Pennsylvania
  摘要：Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccine targeting C. difficile toxins and virulence factors. This multivalent vaccine elicited robust and long-lived systemic and mucosal antigen-specific humoral and cellular immune responses across animal models, independent of changes to the intestinal microbiota. Vaccination protected mice from lethal CDI in...