作者：Bialic-Murphy, Lalasia; McElderry, Robert M.; Esquivel-Muelbert, Adriane; van den Hoogen, Johan; Zuidema, Pieter A.; Phillips, Oliver L.; de Oliveira, Edmar Almeida; Loayza, Patricia Alvarez; Alvarez-Davila, Esteban; Alves, Luciana F.; Maia, Vinicius Andrade; Vieira, Simone Aparecida; Arantes da Silva, Lidiany Carolina; Araujo-Murakami, Alejandro; Arets, Eric; Astigarraga, Julen; Baccaro, Fabricio; Baker, Timothy; Banki, Olaf; Barroso, Jorcely; Blanc, Lilian; Bonal, Damien; Bongers, Frans; Bordin, Kauane Maiara; Brienen, Roel; de Medeiros, Marcelo Brilhante; Camargo, Jose Luis; Araujo, Felipe Carvalho; Castilho, Carolina V.; Castro, Wendeson; Moscoso, Victor Chama; Comiskey, James; Costa, Flavia; Mueller, Sandra Cristina; de Almeida, Everton Cristo; Lola da Costa, Antonio Carlos; de Andrade Kamimura, Vitor; de Oliveira, Fernanda; del Aguila Pasquel, Jhon; Derroire, Geraldine; Dexter, Kyle; Di Fiore, Anthony; Duchesne, Louis; Emilio, Thaise; Farrapo, Camila Lais; Fauset, Sophie; Draper, Frederick C.; Feldpausch, Ted R.; Ramos, Rafael Flora; Martins, Valeria Forni; Simon, Marcelo Fragomeni; Reis, Miguel Gama; Manzatto, Angelo Gilberto; Herault, Bruno; Herrera, Rafael; Coronado, Euridice Honorio; Howe, Robert; Huamantupa-Chuquimaco, Isau; Huasco, Walter Huaraca; Zanini, Katia Janaina; Joly, Carlos; Killeen, Timothy; Klipel, Joice; Laurance, Susan G.; Laurance, William F.; Fontes, Marco Aurelio Leite; Oviedo, Wilmar Lopez; Magnusson, William E.; dos Santos, Rubens Manoel; Pena, Jose Luis Marcelo; de Abreu, Karla Maria Pedra; Marimon, Beatriz; Marimon Junior, Ben Hur; Melgaco, Karina; Melo Cruz, Omar Aurelio; Mendoza, Casimiro; Monteagudo-Mendoza, Abel; Morandi, Paulo S.; Gianasi, Fernanda Moreira; Nascimento, Henrique; Nascimento, Marcelo; Neill, David; Palacios, Walter; Camacho, Nadir C. Pallqui; Pardo, Guido; Pennington, R. Toby; Penuela-Mora, Maria Cristina; Pitman, Nigel C. A.; Poorter, Lourens; Cruz, Adriana Prieto; Ramirez-Angulo, Hirma; Reis, Simone Matias; Correa, Zorayda Restrepo; Rodriguez, Carlos Reynel; Lleras, Agustin Rudas; Santos, Flavio A. M.; Bergamin, Rodrigo Scarton; Schietti, Juliana; Schwartz, Gustavo; Serrano, Julio; Silva-Sene, Andre Maciel; Silveira, Marcos; Stropp, Juliana; ter Steege, Hans; Terborgh, John; Tobler, Mathias W.; Gamarra, Luis Valenzuela; van der Meer, Peter J.; van der Heijden, Geertje; Vasquez, Rodolfo; Vilanova, Emilio; Vos, Vincent Antoine; Wolf, Amy; Woodall, Christopher W.; Wortel, Verginia; Zwerts, Joeri A.; Pugh, Thomas A. M.; Crowther, Thomas W.
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; University of Birmingham; Wageningen University & Research; University of Leeds; Duke University; University of California System; University of California Los Angeles; Universidade Federal de Lavras; Universidade Estadual de Campinas; Wageningen University & Research; Universidad de Alcala; Universidade Federal de Amazonas; Naturalis Biodiversity Center; Universidade Federal do Acre (UFAC); Universite de Montpellier; CIRAD; INRAE; Universite de Lorraine; AgroParisTech; Wageningen University & Research; Universidade Federal do Rio Grande do Sul; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Genetic Resources & Biotechnology; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Roraima; Universidade Federal do Acre (UFAC); Universidad Nacional de San Antonio Abad del Cusco; United States Department of the Interior; US National Park Service; Smithsonian Institution; Institute Nacional de Pesquisas da Amazonia; Universidade Federal do Oeste do Para; Universidade Federal do Para; Instituto Tecnologico Vale Desenvolvimento Sustentavel; Universidad Nacional de la Amazonia Peruana; CIRAD; INRAE; AgroParisTech; University of Edinburgh; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Universidad San Francisco de Quito; Universidade Estadual de Campinas; Universidade de Sao Paulo; University of Plymouth; University of Liverpool; University of Exeter; Universidade de Sao Paulo; Universidade Estadual de Campinas; Universidade Federal de Sao Carlos; University of St Andrews; University of Wisconsin System; University of Wisconsin Green Bay; Universidad Nacional Amazonica De Madre De Dios; University of Oxford; Universidade Estadual de Campinas; Universidade de Sao Paulo; Missouri Botanical Gardens; James Cook University; Institute Nacional de Pesquisas da Amazonia; Universidad Nacional de Jaen; Universidad Nacional de Jaen; Instituto Federal do Espirito Santo (IFES); Universidad del Tolima; Universidad Mayor de San Simon; Universidad Nacional de San Antonio Abad del Cusco; Institute Nacional de Pesquisas da Amazonia; Universidade Estadual do Norte Fluminense; University of Exeter; Field Museum of Natural History (Chicago); University of Los Andes Venezuela; Universidade Federal do Acre (UFAC); Universidad Nacional Agraria La Molina; Universidad Nacional de Colombia; University of Birmingham; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA); University of Los Andes Venezuela; Universidade Federal do Acre (UFAC); Universitat Trier; Utrecht University; State University System of Florida; University of Florida; University of Nottingham; University of Wisconsin System; University of Wisconsin Green Bay; United States Department of Agriculture (USDA); United States Forest Service; Utrecht University; Lund University; Universidade Estadual Paulista; Leuphana University Luneburg
摘要：Tree growth and longevity trade-offs fundamentally shape the terrestrial carbon balance. Yet, we lack a unified understanding of how such trade-offs vary across the world's forests. By mapping life history traits for a wide range of species across the Americas, we reveal considerable variation in life expectancies from 10 centimeters in diameter (ranging from 1.3 to 3195 years) and show that the pace of life for trees can be accurately classified into four demographic functional types. We foun...
作者：Sarott, Roman C.; Gourisankar, Sai; Karim, Basel; Nettles, Sabin; Yang, Haopeng; Dwyer, Brendan G.; Simanauskaite, Juste M.; Tse, Jason; Abuzaid, Hind; Krokhotin, Andrey; Zhang, Tinghu; Hinshaw, Stephen M.; Green, Michael R.; Crabtree, Gerald R.; Gray, Nathanael S.
作者单位：Stanford University; Stanford University; Stanford University; University of Texas System; UTMD Anderson Cancer Center; Stanford University
摘要：Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit their catalytic activity, but here we used chemically induced proximity to convert kinase inhibitors into activators of therapeutic genes. We synthesized bivalent molecules that link ligands of the transcription factor B cell lymphoma 6 (BCL6) to inhibitors of cyclin-dependent kinases (CDKs). These molecules relocalize...
