Cancer immunotherapy by γδ T cells

• 成果类型: Review
• 署名作者: Hayday, Adrian; Dechanet-Merville, Julie; Rossjohn, Jamie; Silva-Santos, Bruno
• 署名单位: Francis Crick Institute; University of London; King's College London; Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; Monash University; Monash University; Cardiff University; Universidade de Lisboa
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10950
• DOI: 10.1126/science.abq7248
• 发表日期: 2024-10-04
• 关键词: butyrophilin btn; antigen receptor; immune-response; tcr; RECOGNITION; activation; generation; molecules; infection; expansion

摘要

The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and immunological memory can jointly eradicate cancers and inoperable metastases and de facto vaccinate against recurrence. For some patients with hitherto incurable diseases, including metastatic melanoma, this promise is being realized by game-changing immunotherapies based on alpha beta T cells. Today's challenges are to bring benefit to greater numbers of patients of diverse ethnicities, target more cancer types, and achieve a cure while incurring fewer adverse events. In meeting those challenges, specific benefits may be offered by gamma delta T cells, which compose a second T cell lineage with distinct recognition capabilities and functional traits that bridge innate and adaptive immunity. gamma delta T cell-based clinical trials, including off-the-shelf adoptive cell therapy and agonist antibodies, are yielding promising results, although identifiable problems remain. In addressing those problems, we advocate that immunotherapies be guided by the distinctive biology of gamma delta T cells, as elucidated by ongoing research.