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作者：An, Joon-Yong; Kim, Yujin
作者单位：Korea University; Korea University; Korea University
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作者：Sanczuk, Pieter; Verheyen, Kris; Lenoir, Jonathan; Zellweger, Florian; Lembrechts, Jonas J.; Rodriguez-Sanchez, Francisco; Baeten, Lander; Bernhardt-Roemermann, Markus; De Pauw, Karen; Vangansbeke, Pieter; Perring, Michael P.; Berki, Imre; Bjorkman, Anne D.; Brunet, Joerg; Chudomelova, Marketa; De Lombaerde, Emiel; Decocq, Guillaume; Dirnbock, Thomas; Durak, Tomasz; Greiser, Caroline; Hedl, Radim; Heinken, Thilo; Jandt, Ute; Jaroszewicz, Bogdan; Kopecky, Martin; Landuyt, Dries; Macek, Martin; Malis, Frantisek; Naaf, Tobias; Nagel, Thomas A.; Petrik, Petr; Reczynska, Kamila; Schmidt, Wolfgang; Standovar, Tibor; Staude, Ingmar R.; Swierkosz, Krzysztof; Teleki, Balazs; Vanneste, Thomas; Vild, Ondrej; Waller, Donald; De Frenne, Pieter
作者单位：Ghent University; Universite de Picardie Jules Verne (UPJV); Centre National de la Recherche Scientifique (CNRS); Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; University of Antwerp; Utrecht University; University of Sevilla; Friedrich Schiller University of Jena; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); UK Centre for Ecology & Hydrology (UKCEH); University of Western Australia; University of West Hungary; University of Gothenburg; University of Gothenburg; Swedish University of Agricultural Sciences; Czech Academy of Sciences; Institute of Botany of the Czech Academy of Sciences; University of Rzeszow; Stockholm University; Swedish University of Agricultural Sciences; Palacky University Olomouc; University of Potsdam; Martin Luther University Halle Wittenberg; University of Warsaw; Czech Academy of Sciences; Institute of Botany of the Czech Academy of Sciences; Czech University of Life Sciences Prague; Technical University Zvolen; National Forest Center - Slovakia; Leibniz Association; Leibniz Zentrum fur Agrarlandschaftsforschung (ZALF); University of Ljubljana; Czech University of Life Sciences Prague; University of Gottingen; Eotvos Lorand University; Leipzig University; University of Wroclaw; University of Debrecen; University of Wisconsin System; University of Wisconsin Madison
摘要：Climate change is commonly assumed to induce species' range shifts toward the poles. Yet, other environmental changes may affect the geographical distribution of species in unexpected ways. Here, we quantify multidecadal shifts in the distribution of European forest plants and link these shifts to key drivers of forest biodiversity change: climate change, atmospheric deposition (nitrogen and sulfur), and forest canopy dynamics. Surprisingly, westward distribution shifts were 2.6 times more lik...
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作者：Chajwa, Rahul; Flaum, Eliott; Bidle, Kay D.; Van Mooy, Benjamin; Prakash, Manu
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Rutgers University System; Rutgers University New Brunswick; Woods Hole Oceanographic Institution
摘要：Gravity-driven sinking of marine snow sequesters carbon in the ocean, constituting a key biological pump that regulates Earth's climate. A mechanistic understanding of this phenomenon is obscured by the biological richness of these aggregates and a lack of direct observation of their sedimentation physics. Utilizing a scale-free vertical tracking microscopy in a field setting, we present microhydrodynamic measurements of freshly collected marine snow aggregates from sediment traps. Our observa...
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作者：Fabreges, Dimitri; Corominas-Murtra, Bernat; Moghe, Prachiti; Kickuth, Alison; Ichikawa, Takafumi; Iwatani, Chizuru; Tsukiyama, Tomoyuki; Daniel, Nathalie; Gering, Julie; Stokkermans, Anniek; Wolny, Adrian; Kreshuk, Anna; Duranthon, Veronique; Uhlman, Virginie; Hannezo, Edouard; Hiiragi, Takashi
作者单位：Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); European Molecular Biology Laboratory (EMBL); University of Graz; Kyoto University; Kyoto University; Shiga University of Medical Science; INRAE; Universite Paris Saclay; European Molecular Biology Laboratory (EMBL); Universite Paris Saclay; Ecole Nationale Veterinaire d'Alfort (ENVA); European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; Institute of Science & Technology - Austria; Technische Universitat Dresden; Max Planck Society; University of Zurich
摘要：How living systems achieve precision in form and function despite their intrinsic stochasticity is a fundamental yet ongoing question in biology. We generated morphomaps of preimplantation embryogenesis in mouse, rabbit, and monkey embryos, and these morphomaps revealed that although blastomere divisions desynchronized passively, 8-cell embryos converged toward robust three-dimensional shapes. Using topological analysis and genetic perturbations, we found that embryos progressively changed the...
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作者：Tsang, Chi Shing; Zheng, Xiaodong; Yang, Tong; Yan, Zhangyuan; Han, Wei; Wong, Lok Wing; Liu, Haijun; Gao, Shan; Leung, Ka Ho; Lee, Chun-Sing; Lau, Shu Ping; Yang, Ming; Zhao, Jiong; Ly, Thuc Hue
作者单位：Hong Kong Polytechnic University; City University of Hong Kong; City University of Hong Kong; Hong Kong Polytechnic University; City University of Hong Kong; City University of Hong Kong; Shenzhen Research Institute, City University of Hong Kong; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Hong Kong Polytechnic University
摘要：We report the observation of an electric field in twisted-bilayer molybdenum disulfide (MoS2) and elucidate its correlation with local polar domains using four-dimensional scanning transmission electron microscopy (4D-STEM) and first-principles calculations. We reveal the emergence of in-plane topological vortices within the periodic moir & eacute; patterns for both commensurate structures at small twist angles and the incommensurate quasicrystal structure that occurs at a 30 degrees twist. Th...
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作者：Bommasani, Rishi; Kapoor, Sayash; Klyman, Kevin; Longpre, Shayne; Ramaswami, Ashwin; Zhang, Daniel; Schaake, Marietje; Ho, Daniel E.; Narayanan, Arvind; Liang, Percy
作者单位：Stanford University; Stanford University; Princeton University; Princeton University; Massachusetts Institute of Technology (MIT); Georgetown University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University
摘要：Foundation models (e.g., GPT-4 and Llama 3.1) are at the epicenter of artificial intelligence (AI), driving technological innovation and billions of dollars in investment. This has sparked widespread demands for regulation. Central to the debate about how to regulate foundation models is the process by which foundation models are released (1)-whether they are made available only to the model developers, fully open to the public, or somewhere in between. Open foundation models can benefit socie...
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作者：Ferdowsi, Ahmad; Zolghadr-Asli, Babak; Aghakouchak, Amir
作者单位：Semnan University; University of Queensland; University of Exeter; University of California System; University of California Irvine
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作者：Boon, Sarah
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作者：Chen, Xi Dawn; Chen, Zeyu; Wythes, George; Zhang, Yifan; Orr, Benno C.; Sun, Gary; Chao, Yu-Kai; Navarro Torres, Andrea; Thao, Ka; Vallurupalli, Mounica; Sun, Jing; Borji, Mehdi; Tkacik, Emre; Chen, Haiqi; Bernstein, Bradley E.; Chen, Fei
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Deciphering the context-specific relationship between sequence and function is a major challenge in genomics. Existing tools for inducing locus-specific hypermutation and evolution in the native genome context are limited. Here we present a programmable platform for long-range, locus-specific hypermutation called helicase-assisted continuous editing (HACE). HACE leverages CRISPR-Cas9 to target a processive helicase-deaminase fusion that incurs mutations across large (>1000-base pair) genomic i...
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作者：Kang, Tae Gun; Lan, Xin; Mi, Tian; Chen, Hongfeng; Alli, Shanta; Lim, Song-Eun; Bhatara, Sheetal; Vasandan, Anoop Babu; Ward, Grace; Bentivegna, Sofia; Jang, Josh; Spatz, Marianne L.; Han, Jin-Hwan; Schlotmann, Balthasar Clemens; Jespersen, Jakob Schmidt; Derenzo, Christopher; Vogel, Peter; Yu, Jiyang; Baylin, Stephen; Jones, Peter; O'Connell, Casey; Gronbaek, Kirsten; Youngblood, Ben; Zebley, Caitlin C.
作者单位：St Jude Children's Research Hospital; University of Tennessee System; University of Tennessee Health Science Center; St Jude Children's Research Hospital; University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; University of Copenhagen; Van Andel Institute; Merck & Company; Merck & Company USA; Rigshospitalet; University of Copenhagen; Copenhagen University Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Johns Hopkins University; Johns Hopkins Medicine; University of Southern California; University of Copenhagen
摘要：Epigenetic reinforcement of T cell exhaustion is known to be a major barrier limiting T cell responses during immunotherapy. However, the core epigenetic regulators restricting antitumor immunity during prolonged antigen exposure are not clear. We investigated three commonly mutated epigenetic regulators that promote clonal hematopoiesis to determine whether they affect T cell stemness and response to checkpoint blockade immunotherapy. CD8 T cells lacking Dnmt3a, Tet2, or Asxl1 preserved a pro...
