6723期

最新文章

• Truly listening AI翻译
  作者：Kamerkar, Sukrut C.
  作者单位：Dartmouth College
• Advancing alternative methods to reduce animal testing AI翻译
  作者：Nelson, Chad P.; Brown, Paul; Fitzpatrick, Suzanne; Ford, Kevin A.; Howard, Paul C.; Macgill, Tracy; Margerrison, Edward E. C.; O'Shaughnessy, Jacqueline; Patterson, Tucker A.; Raghuwanshi, Rakesh; Rouse, Rodney; Stromgren, Selen; Sung, Kyung E.; Valerio, Luis G.; Ward, Jeffrey L.; Bumpus, Namandje N.
  作者单位：US Food & Drug Administration (FDA); US Food & Drug Administration (FDA); US Food & Drug Administration (FDA); US Food & Drug Administration (FDA); US Food & Drug Administration (FDA); US Food & Drug Administration (FDA); US Food & Drug Administration (FDA); Center for Biologics Evaluation & Research (CBER); US Food & Drug Administration (FDA); FDA Center for Tobacco Products (CTP); US Food & Drug Administration (FDA); US Food & Drug Administration (FDA)
  摘要：Animal studies have been essential to advancing understanding of diseases and development of therapies and are critical to evaluate the potential for toxicity, safety, and, at times, effectiveness, of consumer products (e.g., medical products, foods, tobacco products, and cosmetics). Although animal toxicity studies have proven essential for identifying potential human risks, finding ways to reduce the use of animals and develop effective alternatives is an important effort. Advances in biolog...
• 'America first' could affect health worldwide AI翻译
  作者：Vogel, Gretchen
• Synchronous recognition of amines in oxidative carbonylation toward unsymmetrical ureas AI翻译
  作者：Wang, Jinhui; Wang, Shengchun; Wei, Zhihong; Wang, Pengjie; Cao, Yanwei; Huang, Yang; He, Lin; Lei, Aiwen
  作者单位：Chinese Academy of Sciences; Lanzhou Institute of Chemical Physics, CAS; Wuhan University; Shanxi University
  摘要：Unsymmetrical ureas are commonly found in pharmaceuticals and bioactive compounds. However, devising strategies to introduce two distinct amines selectively in the construction of unsymmetrical ureas remains a challenge. In this work, we use a synchronous recognition strategy that takes advantage of radical and nucleophilic activation to discriminate between secondary and primary amines. Specifically, a copper catalyst preferentially oxidizes secondary amines to radical species, whereas a coba...
• The counterattack AI翻译
  作者：Couzin-Frankel, Jennifer
• Diverse and larger tree islands promote native tree diversity in oil palm landscapes AI翻译
  作者：Paterno, Gustavo B.; Brambach, Fabian; Guerrero-Ramierez, Nathaly; Zemp, Delphine Clara; Cantillo, Aiza F.; Camarretta, Nicolo; Moura, Carina C. M.; Gailing, Oliver; Ballauff, Johannes; Polle, Andrea; Schlund, Michael; Erasmi, Stefan; Iddris, Najeeb A.; Khokthong, Watit; Sundawati, Leti; Irawan, Bambang; Hoelscher, Dirk; Kreft, Holger
  作者单位：University of Gottingen; University of Gottingen; University of Gottingen; University of Neuchatel; University of Gottingen; University of Gottingen; University of Gottingen; University of Twente; Johann Heinrich von Thunen Institute; University of Gottingen; University of Bonn; University of Gottingen; Chiang Mai University; Bogor Agricultural University; Universitas Jambi; Universitas Jambi
  摘要：In monoculture-dominated landscapes, recovering biodiversity is a priority, but effective restoration strategies have yet to be identified. In this study, we experimentally tested passive and active restoration strategies to recover taxonomic, phylogenetic, and functional diversity of woody plants within 52 tree islands established in an oil palm landscape. Large tree islands and higher initial planted diversity catalyzed diversity recovery, particularly functional diversity at the landscape l...
• Learning the language of DNA AI翻译
  作者：Theodoris, Christina V.
  作者单位：University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco
• Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states AI翻译
  作者：Muir, J.; Lin, S.; Aarrestad, I. K.; Daniels, H. R.; Ma, J.; Tian, L.; Olson, D. E.; Kim, C. K.
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; Max Planck Society
  摘要：Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the specific neurons modulated by a psychedelic to determine their role in driving behavior. Using a light- and calcium-dependent activity integrator, we genetically tagged psychedelic-responsive neurons in the medial prefrontal cortex (mPFC) of mice. Single-nucleus RNA sequencing revealed that the psychedel...
• Ribozyme-activated mRNA trans-ligation enables large gene delivery to treat muscular dystrophies AI翻译
  作者：Lindley, Sean R.; Subbaiah, Kadiam C. Venkata; Priyanka, Fnu; Poosala, Pornthida; Ma, Yijie; Jalinous, Leila; West, Jason A.; Richardson, William A.; Thomas, Tamlyn N.; Anderson, Douglas M.
  作者单位：University of Rochester; University of Rochester; University of Rochester
  摘要：Ribozymes are small catalytic RNA sequences capable of nucleotide-specific self-cleavage found widespread in nature. Ribozyme cleavage generates distinct 2 ',3 '-phosphate and 5 '-hydroxyl termini that resemble substrates for recently characterized RNA repair pathways in cells. We report that ribozyme cleavage of two separate mRNAs activated their scarless trans-ligation and translation into full-length protein in eukaryotic cells, a process that we named StitchR (for Stitch RNA). Optimization...
• Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1 AI翻译
  作者：Lu, Yi; Yue, Chen-Xi; Zhang, Li; Yao, Deqiang; Xia, Ying; Zhang, Qing; Zhang, Xinchen; Li, Shaobai; Shen, Yafeng; Cao, Mi; Guo, Chang-Run; Qin, An; Zhao, Jie; Zhou, Lu; Yu, Ye; Cao, Yu
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; China Pharmaceutical University; University of Texas System; University of Texas Southwestern Medical Center; Shanghai Jiao Tong University; Fudan University; Shanghai Jiao Tong University
  摘要：Precise regulation of intracellular phosphate (Pi) is critical for cellular function, with xenotropic and polytropic retrovirus receptor 1 (XPR1) serving as the sole Pi exporter in humans. The mechanism of Pi efflux, activated by inositol pyrophosphates (PP-IPs), has remained unclear. This study presents cryo-electron microscopy structures of XPR1 in multiple conformations, revealing a transmembrane pathway for Pi export and a dual-binding activation pattern for PP-IPs. A canonical binding sit...