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作者：Baghdadi, Meryem B.; Houtekamer, Ronja M.; Perrin, Louisiane; Rao-Bhatia, Abilasha; Whelen, Myles; Decker, Linda; Bergert, Martin; Perez-Gonzalez, Carlos; Bouras, Reda; Gropplero, Giacomo; Loe, Adrian K. H.; Afkhami-Poostchi, Amin; Chen, Xin; Huang, Xi; Descroix, Stephanie; Wrana, Jeffrey L.; Diz-Munoz, Alba; Gloerich, Martijn; Ayyaz, Arshad; Matic Vignjevic, Danijela; Kim, Tae-Hee
作者单位：Sorbonne Universite; Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); University of Toronto; Hospital for Sick Children (SickKids); Utrecht University; Utrecht University Medical Center; University of Toronto; University of Calgary; University of Calgary; European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; UNICANCER; Institut Curie; Sorbonne Universite; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; University of Toronto; Saint Michaels Hospital Toronto
摘要：Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we investigated the roles of PIEZO mechanosensitive channels in the intestinal stem cell (ISC) niche. We used mouse genetics and single-cell RNA sequencing analysis to assess the requirement for PIEZO channels in ISC maintenance. In vivo measurement of basement membrane stiffness showed that ISCs res...
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作者：Kupferschmidt, Kai
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作者：Else, Holly
摘要：Systematic reviews that aim to extract broad conclusions from many studies are in peril.
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作者：Brainard, Jeffrey
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作者：Coulais, Corentin; van de Groep, Jorik
作者单位：University of Amsterdam
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作者：Iglesias, Cecilia Padilla; Freeman, Erika C.
作者单位：University of Cambridge
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作者：Lopez-Lee, Chloe; Kodama, Lay; Fan, Li; Zhu, Daphne; Zhu, Jingjie; Wong, Man Ying; Ye, Pearly; Norman, Kendra; Foxe, Nessa R.; Ijaz, Laraib; Yu, Fangmin; Chen, Hao; Carling, Gillian K.; Torres, Eileen R.; Kim, Rachel D.; Dubal, Dena B.; Liddelow, Shane A.; Sinha, Subhash C.; Luo, Wenjie; Gan, Li
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of California System; University of California San Francisco; University of California System; University of California San Francisco; New York University
摘要：Alzheimer's disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex chromosomes and gonads in demyelination and AD. In a mouse model of demyelination, we identified the roles of sex chromosomes and gonads in modifying microglia and oligodendrocyte responses before and after myelin loss. In an AD-related mouse model expressing APOE4, XY sex chromosomes heightened i...
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作者：Brainard, Jeffrey
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作者：Luth, Madeline R.; Godinez-Macias, Karla P.; Chen, Daisy; Okombo, John; Thathy, Vandana; Cheng, Xiu; Daggupati, Sindhu; Davies, Heledd; Dhingra, Satish K.; Economy, Jan M.; Edgar, Rebecca C. S.; Gomez-Lorenzo, Maria G.; Istvan, Eva S.; Jado, Juan Carlos; Lamonte, Gregory M.; Melillo, Bruno; Mok, Sachel; Narwal, Sunil K.; Ndiaye, Tolla; Ottilie, Sabine; Palomo Diaz, Sara; Park, Heekuk; Pena, Stella; Rocamora, Frances; Sakata-Kato, Tomoyo; Small-Saunders, Jennifer L.; Summers, Robert L.; Tumwebaze, Patrick K.; Vanaerschot, Manu; Xia, Guoqin; Yeo, Tomas; You, Ashley; Gamo, Francisco-Javier; Goldberg, Daniel E.; Lee, Marcus C. S.; Mcnamara, Case W.; Ndiaye, Daouda; Rosenthal, Philip J.; Schreiber, Stuart L.; Serra, Gloria; De Siqueira-Neto, Jair Lage; Skinner-Adams, Tina S.; Uhlemann, Anne-Catrin; Kato, Nobutaka; Lukens, Amanda K.; Wirth, Dyann F.; Fidock, David A.; Winzeler, Elizabeth A.
作者单位：University of California System; University of California San Diego; NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Columbia University; Wellcome Trust Sanger Institute; University of Dundee; GlaxoSmithKline; Glaxosmithkline Spain; Washington University (WUSTL); Washington University (WUSTL); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; NewYork-Presbyterian Hospital; Columbia University; Universidad de la Republica, Uruguay; Nagasaki University; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Scripps Research Institute; Scripps Research Institute; University of California System; University of California San Francisco; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California San Diego; Griffith University; Griffith University
摘要：Surveillance of drug resistance and the discovery of novel targets-key objectives in the fight against malaria-rely on identifying resistance-conferring mutations in Plasmodium parasites. Current approaches, while successful, require laborious experimentation or large sample sizes. To elucidate shared determinants of antimalarial resistance that can empower in silico inference, we examined the genomes of 724 Plasmodium falciparum clones, each selected in vitro for resistance to one of 118 comp...
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作者：Wang, Huping; Hegde, Ramanujan S.
作者单位：MRC Laboratory Molecular Biology
摘要：The eukaryotic signal recognition particle (SRP) cotranslationally recognizes the first hydrophobic segment of nascent secretory and membrane proteins and delivers them to a receptor at the endoplasmic reticulum (ER). How substrates are released from SRP at the ER to subsequently access translocation factors is not well understood. We found that TMEM208 can engage the substrate binding domain of SRP to accelerate release of its bound cargo. Without TMEM208, slow cargo release resulted in exces...
