6725期

最新文章

• Children are left behind in Congo's mpox vaccination drive AI翻译
  作者：Cohen, Jon
• Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels AI翻译
  作者：Junkins, Madeleine S.; Feng, Ni Y.; Merriman, Dana K.; Bagriantsev, Sviatoslav N.; Gracheva, Elena O.
  作者单位：Yale University; Yale University; Yale University; Yale University; University of Wisconsin System; University of Wisconsin Oshkosh; Yale University; Wesleyan University
  摘要：Water deprivation is a life-threatening condition that engages a protective physiological response to couple osmolyte retention with potentiation of thirst. This response, typical for most mammals, safeguards against short-term water deprivation but fails in the long term. Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) use the short-term response during summer, whereas during winter, they lack thirst and survive without water for months. In this work, we show that long-term thirs...
• 'Dark proteome' survey reveals thousands of new human genes: Database confirms that overlooked segments of the genome code for a multitude of tiny proteins AI翻译
  作者：Pennisi, Elizabeth
• Mining lithium from brines goes electric AI翻译
  作者：Service, Robert F.
• Optoelectronic metadevices AI翻译
  作者：Ha, Son Tung; Li, Qitong; Yang, Joel K. W.; Demir, Hilmi Volkan; Brongersma, Mark L.; Kuznetsov, Arseniy I.
  作者单位：Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Materials Research & Engineering (IMRE); Stanford University; Singapore University of Technology & Design; Nanyang Technological University; Ihsan Dogramaci Bilkent University
  摘要：Metasurfaces have introduced new opportunities in photonic design by offering unprecedented, nanoscale control over optical wavefronts. These artificially structured layers have largely been used to passively manipulate the flow of light by controlling its phase, amplitude, and polarization. However, they can also dynamically modulate these quantities and manipulate fundamental light absorption and emission processes. These valuable traits can extend their application domain to chipscale optoe...
• A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing AI翻译
  作者：Zheng, Ge; Yin, Maolu; Mehta, Stuti; Chu, I-Te; Wang, Stacy; Alshaye, Alia; Drainville, Kirstin; Buyanbat, Altantsetseg; Bienfait, Frederique; Tenglin, Karin; Zhu, Qian; Orkin, Stuart H.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Baylor College of Medicine
  摘要：Down-regulation of BCL11A protein reverses the fetal (HbF, alpha 2 gamma 2) to adult (HbA, alpha 2 beta 2) hemoglobin switch and is exploited in gene-based therapy for hemoglobin disorders. Because of reliance on ex vivo cell manipulation and marrow transplant, such therapies cannot lessen disease burden. To develop new small-molecule approaches, we investigated the state of BCL11A protein in erythroid cells. We report that tetramer formation mediated by a single zinc finger (ZnF0) is required...
• Assessment abuse in African protected areas AI翻译
  作者：Alberts, Reece; Retief, Francois; Bond, Alan; Roos, Claudine; Cilliers, Dirk
  作者单位：North West University - South Africa; University of East Anglia
• Journal dumps shady platforms AI翻译
  作者：Brainard, Jeffrey
• Decadal oscillations in the ocean's largest oxygen-deficient zone AI翻译
  作者：Duprey, N. N.; Foreman, A. D.; Carriquiry, J. D.; Charles, C. D.; Sanchez, S. C.; Vonhof, H.; Rubach, F.; Rabenstein, R.; Rohr, M.; Reyes-Bonilla, H.; Marconi, D.; Sigman, D. M.; Haug, G. H.; Martinez-Garcia, A.
  作者单位：Max Planck Society; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Colorado System; University of Colorado Boulder; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Universidad Autonoma de Baja California; Princeton University; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：The impact of global warming on the ocean's oxygen-deficient zones (ODZs) is uncertain, partly because of a lack of data on past changes. We report monthly resolved records of coral skeleton-bound nitrogen isotopes (CS-delta 15N) to reconstruct denitrification in the Eastern Tropical North Pacific (ETNP) ODZ over the last 80 years. The data indicate strong decadal variation in ETNP denitrification, with maxima during the cool North Pacific phase of Pacific Decadal Variability. The maxima in de...
• Microscale droplet assembly enables biocompatible multifunctional modular iontronics AI翻译
  作者：Zhang, Yujia; Tan, Cheryl M. J.; Toepfer, Christopher N.; Lu, Xin; Bayley, Hagan
  作者单位：University of Oxford; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Oxford; Ludwig Institute for Cancer Research; University of Oxford
  摘要：Hydrogel iontronic devices can emulate biological functions and communicate with living matter. But the fabrication of miniature, soft iontronic devices according to modular designs has not been achieved. In this work, we report the use of surfactant-supported assembly of freestanding microscale hydrogel droplets to construct various iontronic modules, circuits, and biointerfaces. Chemical modifications of silk fibroin produced a pair of oppositely charged hydrogels. Microscale assembly of var...