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作者：Rouce, Rayne H.; Porteus, Matthew H.
作者单位：Baylor College of Medicine; Baylor College Medical Hospital; Stanford University; Stanford University
摘要：Patients with devastating illnesses demonstrate incredible courage in battling their disease. Innovative cell and gene therapies (CGTs), built on decades of research, are changing the lives of those who suffer from conditions ranging from cancer to sickle cell disease to neurologic diseases. Although hailed for their promise and recognized for benefits that will exceed the costs, the high prices of CGTs ($300 thousand to $4 million per dose) leave these therapies out of reach for many. This ac...
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作者：Zhao, Qiancheng
作者单位：Baylor College of Medicine; Yale University
摘要：Our hearts race with emotion as we are enthralled by the mesmerizing love story in the movie Titanic. Our hunger stirs to life as we are enchanted by the tantalizing cuisine showcased in Ratatouille. Our breath hangs in suspense as we are electrified by the adrenaline- pumping moments in Mission Impossible. Both external and internal experiences shape the very essence of our lives.
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作者：Couzin-Frankel, Jennifer
摘要：New efforts seek causal links between pathogens and dementia
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作者：Yoon, Peter H.; Zhang, Zeyuan; Loi, Kenneth J.; Adler, Benjamin A.; Lahiri, Arushi; Vohra, Kamakshi; Shi, Honglue; Rabelo, Daniel Bellieny; Trinidad, Marena; Boger, Ron S.; Al-Shimary, Muntathar J.; Doudna, Jennifer A.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California San Francisco; The J David Gladstone Institutes; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley
摘要：The RNA-guided ribonuclease CRISPR-Cas13 enables adaptive immunity in bacteria and programmable RNA manipulation in heterologous systems. Cas13s share limited sequence similarity, hindering discovery of related or ancestral systems. To address this, we developed an automated structural-search pipeline to identify an ancestral clade of Cas13 (Cas13an) and further trace Cas13 origins to defense-associated ribonucleases. Despite being one-third the size of other Cas13s, Cas13an mediates robust pr...
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作者：An, Zhisheng; Zhou, Weijian; Zhang, Zeke; Zhang, Xu; Liu, Zhonghui; Sun, Youbin; Clemens, Steven C.; Wu, Lixin; Zhao, Jiaju; Shi, Zhengguo; Ma, Xiaolin; Yan, Hong; Li, Gaojun; Cai, Yanjun; Yu, Jimin; Sun, Yuchen; Li, Siqi; Zhang, Yu'ao; Stepanek, Christian; Lohmann, Gerrit; Dong, Guocheng; Cheng, Hai; Liu, Yu; Jin, Zhangdong; Li, Tao; Hao, Yifei; Lei, Jing; Cai, Wenju
作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Xi'an Jiaotong University; Beijing Normal University; Nanjing University; Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; University of Hong Kong; Brown University; Laoshan Laboratory; Ocean University of China; Australian National University; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Chinese Academy of Sciences
摘要：Despite extensive investigation, the nature and causes of the Mid-Pleistocene Transition remain enigmatic. In this work, we assess its linkage to asynchronous development of bipolar ice sheets by synthesizing Pleistocene mid- to high-latitude proxy records linked to hemispheric ice sheet evolution. Our results indicate substantial growth of the Antarctic Ice Sheets (AISs) at 2.0 to 1.25 million years ago, preceding the rapid expansion of Northern Hemisphere Ice Sheets after similar to 1.25 mil...
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作者：Brainard, Jeffrey
摘要：Authors are increasingly paying to publish their papers open access. But is it fair or sustainable?
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作者：Savitsky, Zack
摘要：Researchers create fresh tools to attack famed Riemann hypothesis, math's biggest unsolved problem
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作者：Dhand, Abhishek P.; Davidson, Matthew D.; Zlotnick, Hannah M.; Kolibaba, Thomas J.; Killgore, Jason P.; Burdick, Jason A.
作者单位：University of Pennsylvania; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA
摘要：Incorporation of polymer chain entanglements within a single network can synergistically improve stiffness and toughness, yet attaining such dense entanglements through vat photopolymerization additive manufacturing [e.g., digital light processing (DLP)] remains elusive. We report a facile strategy that combines light and dark polymerization to allow constituent polymer chains to densely entangle as they form within printed structures. This generalizable approach reaches high monomer conversio...
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作者：Kupferschmidt, Kai
摘要：Twice-yearly lenacapavir injections provide 100% protection in study in African women
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作者：Peters, Jonathan J. P.; Reed, Bryan W.; Jimbo, Yu; Noguchi, Kanako; Mueller, Karin H.; Porter, Alexandra; Masiel, Daniel J.; Jones, Lewys
作者单位：Trinity College Dublin; Trinity College Dublin; Jeol Ltd; Imperial College London
摘要：An ever-present limitation of transmission electron microscopy is the damage caused by high-energy electrons interacting with any sample. By reconsidering the fundamentals of imaging, we demonstrate an event-responsive approach to electron microscopy that delivers more information about the sample for a given beam current. Measuring the time to achieve an electron count threshold rather than waiting a predefined constant time improves the information obtained per electron. The microscope was m...
