-
作者：Sun, Zhao; Kwon, Ji-Sun; Ren, Yudong; Chen, Shawei; Walker, Courtney K.; Lu, Xinguo; Cates, Kitra; Karahan, Hande; Sviben, Sanja; Fitzpatrick, James A. J.; Valdez, Clarissa; Houlden, Henry; Karch, Celeste M.; Bateman, Randall J.; Sato, Chihiro; Mennerick, Steven J.; Diamond, Marc I.; Kim, Jungsu; Tanzi, Rudolph E.; Holtzman, David M.; Yoo, Andrew S.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Washington University (WUSTL); University of Texas System; University of Texas Southwestern Medical Center; University of London; University College London; Washington University (WUSTL); Washington University (WUSTL); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Late-onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's disease (AD). However, modeling sporadic LOAD that endogenously captures hallmark neuronal pathologies such as amyloid-beta (A beta) deposition, tau tangles, and neuronal loss remains an unmet need. We demonstrate that neurons generated by microRNA (miRNA)-based direct reprogramming of fibroblasts from individuals affected by autosomal dominant AD (ADAD) and LOAD in a three-dimensional environment effectively recapitu...
-
作者：King, Barbara J.
-
作者：Rojas-Bracho, Lorenzo; Taylor, Barbara L.; Reeves, Randall R.; Read, Andrew; Barlow, Jay; Donovan, Greg; Thomas, Peter O.; Gulland, Frances; Mesnick, Sarah L.; Brownell, Robert L.; Henry, Annette; Urban, Jorge; Gerrodette, Tim
作者单位：Duke University; Oregon State University; National Oceanic Atmospheric Admin (NOAA) - USA; Universidad Autonoma de Baja California
-
作者：Vergnolle, Nathalie
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); INRAE; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Ecole Nationale Veterinaire de Toulouse
摘要：A chemogenetic screen reveals links between nociceptors and gut immune function
-
作者：Zuckerman, Molly K.; Hofman, Courtney A.
作者单位：Mississippi State University; Mississippi State University; Smithsonian Institution; Smithsonian National Museum of Natural History; University of Oklahoma System; University of Oklahoma - Norman; University of Oklahoma System; University of Oklahoma - Norman
摘要：The skeletons of deceased humans as well as their substrates, such as preserved dental plaque (dental calculus), and biomolecules, such as DNA, represent an archive of many otherwise invisible aspects of the past. In particular, molecular studies of skeletal individuals capture interactions between human hosts, environments, animals, plants, and pathogens (HEAPP) ( 1 , 2 ). When the tools of paleogenomics, such as ancient DNA (aDNA) analyses, are combined with broad collaborations and perspect...
-
作者：Larsen, Anders S.; Rekis, Toms; Madsen, Anders O.
作者单位：University of Copenhagen
摘要：X-ray crystallography provides a distinctive view on the three-dimensional structure of crystals. To reconstruct the electron density map, the complex structure factors F = |F|exp(i phi) of a sufficiently large number of diffracted reflections must be known. In a conventional experiment, only the amplitudes F are obtained, and the phases phi are lost. This is the crystallographic phase problem. In this work, we show that a neural network, trained on millions of artificial structure data, can s...
-
作者：Wadman, Meredith
摘要：Scientists debate the role of humidity in rising heat deaths
-
作者：Enserink, Martin
-
作者：Gupta, Shalini
-
作者：Kellogg, Elizabeth A.
作者单位：Donald Danforth Plant Science Center; Harvard University
摘要：Plant prickles are controlled by genes involved in the final step of cytokinin biosynthesis
