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作者：Dulvy, Nicholas K.; Pacoureau, Nathan; Matsushiba, Jay H.; Yan, Helen F.; Vanderwright, Wade J.; Rigby, Cassandra L.; Finucci, Brittany; Sherman, C. Samantha; Jabado, Rima W.; Carlson, John K.; Pollom, Riley A.; Charvet, Patricia; Pollock, Caroline M.; Hilton-Taylor, Craig; Simpfendorfer, Colin A.
作者单位：Simon Fraser University; Virginia Polytechnic Institute & State University; Ifremer; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Bretagne Occidentale; James Cook University; James Cook University; National Institute of Water & Atmospheric Research (NIWA) - New Zealand; Deakin University; National Oceanic Atmospheric Admin (NOAA) - USA; Universidade Federal do Ceara; University of Tasmania
摘要：The true state of ocean biodiversity is difficult to assess, and there are few global indicators to track the primary threat of overfishing. We calculated a 50-year Red List Index of extinction risk and ecological function for 1199 sharks and rays and found that since 1970, overfishing has halved their populations and their Red List Index has worsened by 19%. Overfishing the largest species in nearshore and pelagic habitats risks loss of ecomorphotypes and a 5 to 22% erosion of functional dive...
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作者：Simic, Milos S.; Watchmaker, Payal B.; Gupta, Sasha; Wang, Yuan; Sagan, Sharon A.; Duecker, Jason; Shepherd, Chanelle; Diebold, David; Pineo-Cavanaugh, Psalm; Haegelin, Jeffrey; Zhu, Robert; Ng, Ben; Yu, Wei; Tonai, Yurie; Cardarelli, Lia; Reddy, Nishith R.; Sidhu, Sachdev S.; Troyanskaya, Olga; Hauser, Stephen L.; Wilson, Michael R.; Zamvil, Scott S.; Okada, Hideho; Lim, Wendell A.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Princeton University; Princeton University; University of Waterloo; Simons Foundation; Flatiron Institute; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center
摘要：To engineer cells that can specifically target the central nervous system (CNS), we identified extracellular CNS-specific antigens, including components of the CNS extracellular matrix and surface molecules expressed on neurons or glial cells. Synthetic Notch receptors engineered to detect these antigens were used to program T cells to induce the expression of diverse payloads only in the brain. CNS-targeted T cells that induced chimeric antigen receptor expression efficiently cleared primary ...
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作者：O'Toole, A.
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作者：Glogl, Matthias; Krishnakumar, Aditya; Ragotte, Robert J.; Goreshnik, Inna; Coventry, Brian; Bera, Asim K.; Kang, Alex; Joyce, Emily; Ahn, Green; Huang, Buwei; Yang, Wei; Chen, Wei; Sanchez, Mariana Garcia; Koepnick, Brian; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
摘要：Despite progress in designing protein-binding proteins, the shape matching of designs to targets is lower than in many native protein complexes, and design efforts have failed for the tumor necrosis factor receptor 1 (TNFR1) and other protein targets with relatively flat and polar surfaces. We hypothesized that free diffusion from random noise could generate shape-matched binders for challenging targets and tested this approach on TNFR1. We obtain designs with low picomolar affinity whose spec...
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作者：Moutinho, Sofia
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作者：Stone, Richard
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作者：Voosen, Paul
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作者：Langin, Katie
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作者：Langin, Katie
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作者：Uweru, Ogochukwu Joseph
作者单位：Oregon Health & Science University
