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作者:Cho, Adrian
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作者:Iasi, Leonardo N. M.; Chintalapati, Manjusha; Skov, Laurits; Mesa, Alba Bossoms; Hajdinjak, Mateja; Peter, Benjamin M.; Moorjani, Priya
作者单位:Max Planck Society; University of California System; University of California Berkeley; Francis Crick Institute; University of Rochester; University of California System; University of California Berkeley
摘要:Gene flow from Neanderthals has shaped genetic and phenotypic variation in modern humans. We generated a catalog of Neanderthal ancestry segments in more than 300 genomes spanning the past 50,000 years. We examined how Neanderthal ancestry is shared among individuals over time. Our analysis revealed that the vast majority of Neanderthal gene flow is attributable to a single, shared extended period of gene flow that occurred between 50,500 to 43,500 years ago, as evidenced by ancestry correlati...
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作者:Voosen, Paul
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作者:Addae, A. J.
作者单位:University of California System; University of California Los Angeles
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作者:Brainard, Jeffrey
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作者:Andrews, Anne Milasincic
作者单位:University of California System; University of California Los Angeles
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作者:Cohen, Jon
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作者:Xie, Feng; Zhao, Haowen; Liu, Jiaqi; Yang, Xiaoli; Neuber, Markus; Agrawal, Amay Ajaykumar; Kaur, Amninder; Herrmann, Jennifer; Kalinina, Olga V.; Wei, Xiaoyi; Mueller, Rolf; Fu, Chengzhang
作者单位:Helmholtz Association; Helmholtz-Center for Infection Research; Helmholtz Association; Helmholtz-Center for Infection Research; Universitatsklinikum des Saarlandes; Chinese Academy of Sciences; South China Botanical Garden, CAS; Saarland University; German Center for Infection Research
摘要:The transmission of antibiotic-resistance genes, comprising mobilization and relocation events, orchestrates the dissemination of antimicrobial resistance. Inspired by this evolutionarily successful paradigm, we developed ACTIMOT, a CRISPR-Cas9-based approach to unlock the vast chemical diversity concealed within bacterial genomes. ACTIMOT enables the efficient mobilization and relocation of large DNA fragments from the chromosome to replicative plasmids within the same bacterial cell. ACTIMOT...
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作者:Brainard, Jeffrey
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作者:Urban, Mark C.
作者单位:University of Connecticut; University of Connecticut; University of Aberdeen
摘要:Climate change is expected to cause irreversible changes to biodiversity, but predicting those risks remains uncertain. I synthesized 485 studies and more than 5 million projections to produce a quantitative global assessment of climate change extinctions. With increased certainty, this meta-analysis suggests that extinctions will accelerate rapidly if global temperatures exceed 1.5 degrees C. The highest-emission scenario would threaten approximately one-third of species, globally. Amphibians...