2024

最新文章

• A sustainability science prize-reserved, so far, for men AI翻译
  作者：Wadman, Meredith
  摘要：Does new Frontiers Planet Prize-with its millions-perpetuate old inequities? Does new Frontiers Planet Prize-with its millions-perpetuate old inequities?
• Aggregate-selective removal of pathological tau by clustering-activated degraders AI翻译
  作者：Benn, Jonathan; Cheng, Shi; Keeling, Sophie; Smith, Annabel E.; Vaysburd, Marina J.; Boken, Dorothea; Miller, Lauren V. C.; Katsinelos, Taxiarchis; Franco, Catarina; Dupre, Elian; Danis, Clement; Landrieu, Isabelle; Buee, Luc; Klenerman, David; James, Leo C.; McEwan, William A.
  作者单位：University of Cambridge; MRC Laboratory Molecular Biology; Centre National de la Recherche Scientifique (CNRS); Universite de Lille; CHU Lille; Pasteur Network; Institut Pasteur Lille; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Lille; CHU Lille; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Selective degradation of pathological protein aggregates while sparing monomeric forms is of major therapeutic interest. The E3 ligase tripartite motif-containing protein 21 (TRIM21) degrades antibody-bound proteins in an assembly state-specific manner due to the requirement of TRIM21 RING domain clustering for activation, yet effective targeting of intracellular assemblies remains challenging. Here, we fused the RING domain of TRIM21 to a target-specific nanobody to create intracellularly exp...
• Micronuclear collapse from oxidative damage AI翻译
  作者：Di Bona, Melody; Chen, Yanyang; Agustinus, Albert S.; Mazzagatti, Alice; Duran, Mercedes A.; Deyell, Matthew; Bronder, Daniel; Hickling, James; Hong, Christy; Scipioni, Lorenzo; Tedeschi, Giulia; Martin, Sara; Li, Jun; Ruzgaite, Ausrine; Riaz, Nadeem; Shah, Parin; D'Souza, Edridge K.; Brodtman, D. Zack; Sidoli, Simone; Diplas, Bill; Jalan, Manisha; Lee, Nancy Y.; Ordureau, Alban; Izar, Benjamin; Laughney, Ashley M.; Powell, Simon; Gratton, Enrico; Santaguida, Stefano; Maciejowski, John; Ly, Peter; Jeitner, Thomas M.; Bakhoum, Samuel F.
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; University of Texas System; University of Texas Southwestern Medical Center; Cornell University; Weill Cornell Medicine; University of California System; University of California Irvine; University of California System; University of California Irvine; IRCCS European Institute of Oncology (IEO); Columbia University; Yeshiva University; Memorial Sloan Kettering Cancer Center; University of Milan; Cornell University; Weill Cornell Medicine
  摘要：Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation, yet mechanisms safeguarding micronuclear integrity are poorly understood. In this study, we found that mitochondria-derived reactive oxygen species (ROS) disrupt micronuclei by promoting a noncanonical function of charg...
• Why Animals Talk:The New Science of Animal Communication AI翻译
  作者：Patricelli, Gail
  作者单位：University of California System; University of California Davis
  摘要：A zoologist probes the origins of complex communication in the animal world
• Safeguard the endemic species of Honduras AI翻译
  作者：Turcios-Casco, Manfredo Alejandro; Lopez, Celeste Maria
  作者单位：Universidade Estadual de Santa Cruz
• The microbial zoo in our food AI翻译
  作者：Brainard, Jeffrey
• Dark matter slips the net again AI翻译
  作者：Brainard, Jeffrey
• Columbia's record research gift AI翻译
  作者：Brainard, Jeffrey
• Stereodivergent access to non-natural α-amino acids via enantio- and Z/E-selective catalysis AI翻译
  作者：Li, Panpan; Zheng, En; Li, Guanlin; Luo, Yicong; Huo, Xiaohong; Ma, Shengming; Zhang, Wanbin
  作者单位：Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Organic Chemistry, CAS; Fudan University
  摘要：The precise control of Z and E configurations of the carbon-carbon double bond in alkene synthesis has long been a fundamental challenge in synthetic chemistry, even more pronounced when simultaneously striving to achieve enantioselectivity [(Z,R), (Z,S), (E,R), (E,S)]. Moreover, enantiopure non-natural alpha-amino acids are highly sought after in organic and medicinal chemistry. In this study, we report a ligand-controlled stereodivergent synthesis of non-natural alpha-quaternary amino acids ...
• Architectural traditions in the structures built by cooperative weaver birds AI翻译
  作者：Tello-Ramos, Maria C.; Harper, Lucy; Tortora-Brayda, Isabella; Guillette, Lauren M.; Capilla-Lasheras, Pablo; Harrison, Xavier A.; Young, Andrew J.; Healy, Susan D.
  作者单位：University of St Andrews; University of Alberta; University of Exeter; University of Glasgow; Swiss Ornithological Institute
  摘要：Humans cooperate to build complex structures with culture-specific architectural styles. However, they are not the only animals to build complex structures nor to have culture. We show that social groups of white-browed sparrow weavers (Plocepasser mahali) build structures (nests for breeding and multiple single-occupant roosts for sleeping) that differ architecturally among groups. Morphological differences are consistent across years and are clear even among groups with territories a few met...