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作者：Sorriso-Valvo, Luca; Malara, Francesco
作者单位：Consiglio Nazionale delle Ricerche (CNR); Istituto per la Scienza Tecnologia dei Plasmi (ISTP-CNR); Royal Institute of Technology; University of Calabria
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作者：Brainard, Jeffrey
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作者：Maddaluno, Marianna; Settembre, Carmine
作者单位：Fondazione Telethon; Telethon Institute of Genetics & Medicine (TIGEM); University of Naples Federico II
摘要：Errors in chromosome segregation during cell division (mitosis) can lead to chromosomal instability, a hallmark of human cancer. These mitotic errors give rise to the formation of micronuclei-small cytoplasmic structures that are spatially separated from the primary nucleus and contain lagging chromosomes or chromosome fragments. Unlike the primary nucleus of a cell, micronuclei frequently undergo irreparable rupture and collapse. This breakdown releases micronuclear DNA into the cytosol, caus...
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作者：Oren, Guy; Shapira, Aner; Lifshitz, Reuven; Vinepinsky, Ehud; Cohen, Roni; Fried, Tomer; Hadad, Guy P.; Omer, David
作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS)
摘要：Humans, dolphins, and elephants are the only known species that vocally label their conspecifics. It remains unclear whether nonhuman primates share this ability. We recorded spontaneous phee-call dialogues between pairs of marmoset monkeys. We discovered that marmosets use these calls to vocally label their conspecifics. Moreover, they respond more consistently and correctly to calls that are specifically directed at them. Analysis of calls from multiple monkeys revealed that family members u...
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作者：Richter, Hannah
摘要：Building a Spanish megalith required sophisticated physics, geometry, and geology
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作者：De Preter, Caitlynn C.; Heinricher, Mary M.
作者单位：Oregon Health & Science University; Oregon Health & Science University
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作者：Pennisi, Elizabeth
作者单位：University of Cape Town
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作者：Kwon, Seokbeom
作者单位：Sungkyunkwan University (SKKU)
摘要：Although federally funded research plays a crucial role in driving innovation ( 1, 2 ), its contribution is underestimated when the US government's research support is not properly acknowledged in patents from an evaluation perspective. Moreover, because the US government is entitled to exercise patents arising from its research support for public safety or public health when the US government's involvement in patents is properly acknowledged, failure to document its research support in patent...
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作者：Brainard, Jeffrey
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作者：Brar, Karinder K.; Hughes, Daniel T.; Morris, Jordan L.; Subramanian, Kelly; Krishna, Shivaani; Gao, Fei; Rieder, Lara-Sophie; Uhrig, Sebastian; Freeman, Joshua; Smith, Heather L.; Jukes-Jones, Rebekkah; Avezov, Edward; Nunnari, Jodi; Prudent, Julien; Butcher, Adrian J.; Mallucci, Giovanna R.
作者单位：University of Cambridge; University of Cambridge; University of Cambridge; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of California System; University of California Davis
摘要：Endoplasmic reticulum (ER) stress induces the repression of protein synthesis throughout the cell. Attempts to understand how localized stress leads to widespread repression have been limited by difficulties in resolving translation rates at the subcellular level. Here, using live-cell imaging of reporter mRNA translation, we unexpectedly found that during ER stress, active translation at mitochondria was significantly protected. The mitochondrial protein ATPase family AAA domain-containing pr...
