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作者：Brainard, Jeffrey
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作者：Alameh, Mohamad-Gabriel; Semon, Alexa; Bayard, Nile U.; Pan, Yi-Gen; Dwivedi, Garima; Knox, James; Glover, Rochelle C.; Rangel, Paula C.; Tanes, Ceylan; Bittinger, Kyle; She, Qianxuan; Hu, Haitao; Bonam, Srinivasa Reddy; Maslanka, Jeffrey R.; Planet, Paul J.; Moustafa, Ahmed M.; Davis, Benjamin; Chevrier, Anik; Beattie, Mitchell; Ni, Houping; Blizard, Gabrielle; Furth, Emma E.; Mach, Robert H.; Lavertu, Marc; Sellmyer, Mark A.; Tam, Ying; Abt, Michael C.; Weissman, Drew; Zackular, Joseph P.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Texas System; University of Texas Medical Branch Galveston; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; American Museum of Natural History (AMNH); Universite de Montreal; Polytechnique Montreal; University of Pennsylvania; University of Pennsylvania
摘要：Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)-lipid nanoparticle (LNP) vaccine targeting C. difficile toxins and virulence factors. This multivalent vaccine elicited robust and long-lived systemic and mucosal antigen-specific humoral and cellular immune responses across animal models, independent of changes to the intestinal microbiota. Vaccination protected mice from lethal CDI in...
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作者：Yang, Rachel
作者单位：Massachusetts Institute of Technology (MIT)
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作者：Mukhles, Gheed; Shakir, Sara; Fulco, Ginevra; Dutra, Daniela de Angeli; Burnette, Katie; Mach, Frantisek; Klocko, Amy Leigh; Ribeiro, Howard Lopes; Turki, Houcemeddine; Bezerra, Paulo; Lu, Zelong; Kim, Bongjae; He, Shihao; Andres, Rigoberto Medina; Obasa, Adetayo Emmanuel; Chua, Song Lin
作者单位：University of Nicosia; Universite de Bordeaux; INRAE; University of Munich; Technical University of Munich; Stanford University; University of California System; University of California Riverside; University of West Bohemia Pilsen; University of Colorado System; University of Colorado at Colorado Springs; Universidade Federal do Ceara; Universite de Sfax; Universidade Federal Rural do Semi-Arido (UFERSA); Xi'an Jiaotong University; Kyungpook National University (KNU); Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Universidad Autonoma del Estado de Morelos; Stellenbosch University; Hong Kong Polytechnic University
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作者：Brainard, Jeffrey
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作者：Tang, Stephen; Conte, Valentin; Zhang, Dennis J.; Zedaveinyte, Rimante; Lampe, George D.; Wiegand, Tanner; Tang, Lauren C.; Wang, Megan; Walker, Matt W. G.; George, Jerrin Thomas; Berchowitz, Luke E.; Jovanovic, Marko; Sternberg, Samuel H.
作者单位：Columbia University; Columbia University; Columbia University; Montana State University System; Montana State University Bozeman; Columbia University; Howard Hughes Medical Institute
摘要：Defense-associated reverse transcriptase (DRT) systems perform DNA synthesis to protect bacteria against viral infection, but the identities and functions of their DNA products remain largely unknown. We show that DRT2 systems encode an unprecedented immune pathway that involves de novo gene synthesis through rolling circle reverse transcription of a noncoding RNA (ncRNA). Programmed template jumping on the ncRNA generates a concatemeric cDNA, which becomes double-stranded upon viral infection...
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Normile, Dennis
